Abstract: The present invention relates to a contrast agent suitable for ex vivo imaging, particularly of vascular structures and renal tubular structures, and a method for ex vivo imaging. The contrast agent is a polymer comprising monomers M. The monomer comprises a backbone having 2 to 6 elements, wherein at least one element is —CH(R)— or —N(R)—. R is a moiety -E-H, -L-(NH2)m or a moiety of formula 1, with E, L, R1 and R2 being defined as described in the present specification. The monomer comprises at least one —I to allow detection via X-ray and at least one —NH2 to allow crosslinking. Furthermore, the monomer comprises polar functional groups that contribute to water solubility. To avoid extravasation and glomerular filtration, the polymers are pre-crosslinked before the vasculature of a tissue, an organ or whole animal is perfused. After perfusion, the pre-crosslinked contrast agent is further crosslinked to be retained within the tissue, organ or animal permanently.

Abstract: A model-order reduction system and methods are described for providing a fast fluid flow simulation model of fluid flow in a conduit such as a blood vessel with stenosis. A first method is described for generating a reduced generic numerical model (20) for predicting fluid flow characteristics of fluid flowing through a subject conduit (7?). In steps 11, 12 and 13, geometric and fluid-flow parameter data are derived from CT image scans for each sampled conduit (7) in a reference set. A 3D model is generated (13) for each sampled conduit (7). The geometric parameter data, the 3D model and the fluid flow parameter data are used to generate solutions to fluid dynamics (such as the Navier-Stokes) equations for each sampled conduit (7), and a full order model is created comprising the geometric parameters data, the fluid flow parameter data and the Navier Stokes solutions.

Abstract: The present invention relates to a cell culture device (1) for use with an optical microscope (40), comprising a housing (10) that is configured to be placed onto a stage of an optical microscope (40) in front of an objective (41) of the microscope (40), the housing (10) enclosing an internal space (11) of the housing (10), a removable flow chamber (2) enclosing an internal space (20) for accommodating a cell culture (CC) comprising living biological cells, a heater (3) arranged in the internal space (11) of the housing (10) for heating said fluid medium (M) to be guided through the flow chamber (2), a first flow path (P1) arranged in the internal space (11) of the housing (10) for guiding said fluid medium (M) towards the flow chamber (2) via said heater (3), and a second flow path (P2) arranged in the internal space (11) of the housing (2) for guiding said fluid medium (M) away from the flow chamber (2), and a pump (4) for pumping said fluid medium (M) through the first flow path (P1) into the internal spac

Abstract: The invention relates to a device for determining a parameter for the diagnostics of hydrocephalus and other disorders of intracranial pressure, wherein information about the volume elasticity is obtained from a pressure signal or another characteristic signal which contains information about the pressure or the volume composition in the skull. The characteristic parameter determined according to the invention is the ratio of the amplitude of a modulating wave in the processed characteristic signal to the amplitude of the modulated wave in the course of the pulse amplitude of the modulated wave of the processed characteristic signal.

Abstract: The present invention refers to an implant with a surface layer having a topographic modification. The topographic modification includes a line pattern with ridge and groove widths of 0.9 to 1.1 ?m and a ridge height of more than 0.9 ?m.

Abstract: The invention relates to an active surface element (2) for improved healing of cell layer lesions comprising at least one topographically structured surface on a substrate, with a pattern comprising alternating ridges (5) and grooves (6) with a pattern period (p) and extending along a pattern length (l), wherein the pattern period (p) is smaller than 10 ?m and the pattern length (l) is larger than 1 mm. The invention furthermore relates to methods of making such an active surface element as well as to bandages, in particular adhesive bandages comprising such active surface elements.

Abstract: The present invention refers to an implant with a surface layer having a topographic modification. The topographic modification includes a line pattern with ridge and groove widths of 0.9 to 1.1 ?m and a ridge height of more than 0.9 ?m.