Abstract: The present invention provides methods for treating or preventing TTR-associated diseases using RNAi agents, e.g., double stranded RNAi agents, that target the transthyretin (TTR) gene.

Abstract: Embodiments described in this disclosure include a process for collecting energy tool usage data from surgical videos and using such data for post surgery analysis. The process can begin by receiving a plurality of surgical videos of a surgical procedure involving an energy tool. For each surgical video in the plurality of surgical videos, the process detects a set of activation events in the surgical video, wherein each detected activation event includes an identified starting timestamp and a duration. The process further extracts a set of energy tool usage data based on the set of detected activation events, and then stores the extracted set of energy tool usage data in a database indexed based on a set of energy tool usage metrics. Next, in response to a user search request, the process returns the stored energy tool usage data that matches the search request from the database.

Abstract: Embodiments described herein include a process for detecting energy tool activations. The process can begin by receiving a surgical video of a surgical procedure involving energy tool activations. The process then applies a sequence of sampling windows to the surgical video to generate a sequence of windowed samples of the surgical video. Next, for each windowed sample in the sequence of windowed samples, the process applies a deep-learning model to a sequence of video frames within the windowed sample to generate an activation/non-activation inference and a confidence level associated with the activation/non-activation inference for the windowed sample. As a result, a sequence of activation/non-activation inferences and a sequence of associated confidence levels are generated. The process subsequently identifies a sequence of activation events in the surgical video based on the sequence of activation/non-activation inferences and the sequence of associated confidence levels.

Abstract: A machine learning model has two stages. In a first stage, features from one or more frames of a surgical video are extracted, wherein the features include presence of a surgical instrument and type of the surgical instrument. A second stage analyzes the surgical video based on the extracted features to recognize a video segment, wherein the recognized video segment includes a detected presence of the surgical instrument, and where the video segment is recognized by a multi-stage temporal convolution network (MS-TCN) or a vision transformer. Other aspects are also described and claimed.

Abstract: The present invention provides methods and compositions for treating a pediatric subject having primary hyperoxaluria and methods for preventing at least one symptom in a pediatric subject having primary hyperoxaluria. The methods include administering to the subject a therapeutically effective amount or a prophylactically effective amount of an RNAi agent, e.g., double-stranded RNAi agent, targeting HAO1.

Abstract: The present invention provides methods for treating or preventing TTR-associated diseases using RNAi agents, e.g., double stranded RNAi agents, that target the transthyretin (TTR) gene.

Abstract: A system for managing access to resources in a plurality of servers by a plurality of client computers by using an operating system independent Secure Shell (SSH) protocol running in each server and using a central policy database that centrally stores access rules which specify access to the servers for a plurality of users/accounts. Each time a target server receives a user request to establish an SSH session, it retrieves associated access rules from the central policy database to obtain the latest access rules. Based on the retrieved rules and the identity of the user and the identity of the client computer, the target server determines whether the user has permission to establish the SSH session with the target server. Using a centralized database and requiring the servers to always retrieve the latest access rules from a central database provides consistent application of the access rules across all servers and all client computers.

Abstract: An access management system receives an access request for a target computer from a client computer. The access request comprises a digital certificate belonging to a user. The access management system verifies the identity of the user by validating the digital certificate. When so verified, the user receives access privileges from a policy database. The access privileges contain one or more access attributes. The access management system evaluates the access request based the one or more access attributes and grants the user access to the target computer if all the one or more access attributes are satisfied.

Abstract: An access management system receives an access request for a target computer from a client computer. The access request comprises a digital certificate belonging to a user. The access management system verifies the identity of the user by validating the digital certificate. When so verified, the user receives access privileges from a policy database. The access privileges contain one or more access attributes. The access management system evaluates the access request based the one or more access attributes and grants the user access to the target computer if all the one or more access attributes are satisfied.

Abstract: An access management system receives an access request for a target computer from a client computer. The access request comprises a digital certificate belonging to a user. The access management system verifies the identity of the user by validating the digital certificate. When so verified, the user receives access privileges from a policy database. The access privileges contain one or more access attributes. The access management system evaluates the access request based the one or more access attributes and grants the user access to the target computer if all the one or more access attributes are satisfied.

Abstract: A system for managing access to resources in a plurality of servers by a plurality of client computers by using an operating system independent Secure Shell (SSH) protocol running in each server and using a central policy database that centrally stores access rules which specify access to the servers for a plurality of users/accounts. Each time a target server receives a user request to establish an SSH session, it retrieves associated access rules from the central policy database to obtain the latest access rules. Based on the retrieved rules and the identity of the user and the identity of the client computer, the target server determines whether the user has permission to establish the SSH session with the target server. Using a centralized database and requiring the servers to always retrieve the latest access rules from a central database provides consistent application of the access rules across all servers and all client computers.