Abstract: Systems, methods, and devices having improved conformal properties for biomedical signal measurement are disclosed. A device can have a first polymer substrate coupled to a conductive layer forming a conductive trace electrically coupled to a conductive pad exposed via an opening. The device can have a second polymer substrate forming a first cavity between the first polymer substrate and the second polymer substrate. The device can have a first inlet portion that receives a fluid that expands the first cavity causing the device to conform to an anatomical structure. The structure can be an atrium, such as the left atrium, of the heart of a patient. The device can conform to the walls of the tissue structure, and the conductive pad exposed via the opening can detect a signal from the wall of the tissue structure. The signal can be provided to an external measurement device for processing.

Abstract: Methods for fabricating flexible/stretchable circuits can include identifying one or more regions of a printed circuit board (PCB) for selectively removing insulation material. The PCB can include one or more electrically conductive structures arranged on an insulation layer. The method can include applying, within each region of the one or more regions, thermal energy via a heat source to a surface of the PCB within the region such that insulation material of the insulation layer is removed from the region while a portion of the insulation layer beneath the one or more electrically conductive structures is maintained. The flexible/stretchable circuit can be laminated on a soft actuator to form a soft robotic device.

Abstract: In some examples, an endovascular system includes an elongated body configured to be introduced into a blood vessel of a patient, a plurality of electrodes carried by the elongated body, and an elongated scaffold configured to be introduced into the blood vessel and configured to transform between a relatively low-profile delivery configuration and a deployed configuration. In the deployed configuration, the elongated scaffold is configured to exert a radial force to urge the elongated body and the plurality of electrodes towards a wall of the blood vessel. After being introduced into the blood vessel of the patient, the elongated scaffold is configured to resorb or degrade over a period of time. A degradation profile of the elongated scaffold over the period of time corresponds to a level of endothelization proximate the plurality of electrodes.

Abstract: Systems and methods for guiding a blood flow restoration procedure (e.g., thrombectomy) are disclosed herein. In some variations in accordance with the present technology, a method for guiding removal of a thrombus includes receiving image data indicative of positions of marker elements on a thrombectomy device positioned proximate the thrombus in a patient, and predicting at least one characteristic of the thrombus by applying a trained machine learning algorithm to the image data.

Abstract: An example system includes processing circuitry; and an endovascular device includes an expandable substrate configured to be delivered endovascularly to a trial therapy delivery location in a patient; one or more first electrodes positioned on the expandable substrate, wherein the one or more first electrodes are configured to deliver nerve tissue stimulation trial therapy to a target nerve tissue of the patient; and one or more second electrodes positioned on the expandable substrate, wherein the one or more second electrodes are configured to sense one or more activation signals of the target nerve tissue, wherein the processing circuitry is configured to determine whether activation of the target nerve tissue at the trial therapy delivery location satisfies a target nerve tissue activation threshold based on the one or more sensed activation signals.

Abstract: Medical systems for depositing fibrin on a medical device ex vivo are disclosed herein. According to some embodiments, the present technology includes a medical system comprising a vascular implant and a package defining a reservoir configured to receive the vascular implant and a volume of blood. The package can include an electrode disposed within the reservoir. The medical system can further include a current generator configured to be electrically coupled to the electrode. Activation of the current generator while the vascular implant and blood are present in the reservoir can cause current to flow through the blood and vascular implant, thereby applying an electrical charge to the vascular implant.

Abstract: A system for treatment of intracranial stenosis can include a catheter having a lumen, and an elongate member extending through the lumen. A distal pressure sensor is coupled to a distal end portion of the elongate member and is configured to obtain blood pressure parameters to characterize blood flow at a treatment site before and after treatment. A stent is disposed within the catheter lumen in a radially constrained configuration. The stent surrounds the elongate member such that the distal end portion of the elongate member is disposed distal to a distal end of the stent. The stent is configured to radially expand into apposition with the blood vessel to increase blood flow at the treatment site when released from the catheter.

Abstract: Systems, methods, and devices having improved conformal properties for biomedical signal measurement are disclosed. A device can have a first polymer substrate coupled to a conductive layer forming a conductive trace electrically coupled to a conductive pad exposed via an opening. The device can have a second polymer substrate forming a first cavity between the first polymer substrate and the second polymer substrate. The device can have a first inlet portion that receives a fluid that expands the first cavity causing the device to conform to an anatomical structure. The structure can be an atrium, such as the left atrium, of the heart of a patient. The device can conform to the walls of the tissue structure, and the conductive pad exposed via the opening can detect a signal from the wall of the tissue structure. The signal can be provided to an external measurement device for processing.

Abstract: An example system includes a first lead configured to be positioned in or beside a left internal jugular vein (IJV) of a patient to deliver a first stimulation signal to a first vagus nerve, the first lead including one or more first segmented electrodes positioned on a distal portion of the first lead and a first anchoring mechanism; a second lead configured to be positioned in or beside a right IJV of the patient to deliver a second stimulation signal to a second vagus nerve, the second lead including one or more second segmented electrodes positioned on a distal portion of the second lead and a second anchoring mechanism; and circuitry configured to deliver electrical energy to the first lead to deliver the first stimulation signal and the second lead to deliver the second stimulation signal to provide bilateral stimulation to the first vagus nerve and the second vagus nerve.

Abstract: An example system includes a collar; a first stimulating electrode array positioned on the collar and configured to delivery stimulation therapy to a patient; a second stimulating electrode array being positioned on the collar and configured to deliver stimulation therapy to the patient; a sensor array being positioned on the collar and configured to detect one or more features indicative of laryngeal muscle activity of the patient; and a controller configured to control stimulation therapy to be delivered via the first stimulating electrode array and the second stimulating electrode array.

Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a signal generator having first and second terminals, and a treatment device with a conductive core member having a proximal end coupled to the first terminal and a distal end. An interventional element comprising the distal end of the core member can include an electrical engagement portion having a plurality of discrete electrodes spaced apart from one another and an expandable distal member disposed distal to the electrical engagement portion.

Abstract: In some examples, an endovascular device includes an elongated body configured to be introduced in a blood vessel of a patient and a plurality of electrodes disposed along the elongated body. The plurality of electrodes includes a first group of electrodes and a second group of electrodes. The endovascular device further includes a plurality of conductors including a first conductor electrically coupled to each electrode of the first group of electrodes and a second conductor electrically coupled to each electrode of the second group of electrodes. Each electrode of the first group of electrodes faces a first direction and each electrode of the second group of electrodes faces a second direction different from the first direction. The plurality of electrodes is configured to deliver electrical stimulation to tissue of a brain of the patient or sense a patient parameter from a location within the blood vessel.

Abstract: In some examples, an endovascular medical device includes an elongated body configured to be introduced in a cranial blood vessel of a patient and an expandable element on the elongated body. The expandable element includes a plurality of loops, wherein each loop includes one or more electrodes. The expandable element is configured to expand radially outwards from a relatively low-profile delivery configuration to a deployed configuration to position the one or more electrodes to deliver electrical stimulation to tissue of a brain of a patient or sense a patient parameter from a location within the cranial blood vessel.