Abstract: The present invention concerns a pharmaceutical composition comprising 0.3% by weight of adapalene or a pharmaceutically acceptable salt thereof and 2.5% by weight of benzoyl peroxide, as active ingredients, for its use by topical administration in the treatment of inflammatory acne lesions. The present invention further concerns regimen for the therapeutic treatment of acne lesions in subjects afflicted with severe acne. The regimen includes topically applying to a subject's skin, as active ingredients, 0.3% by weight adapalene and 2.5% by weight benzoyl peroxide, combined in a single formula that delivers the active ingredients together. The single formula can for example be applied once or twice daily for a period of 8 to 12 weeks.

Abstract: The present invention concerns a pharmaceutical composition comprising 0.3% by weight of adapalene or a pharmaceutically acceptable salt thereof and 2.5% by weight of benzoyl peroxide, as active ingredients, for its use by topical administration in the treatment of inflammatory acne lesions. The present invention further concerns regimen for the therapeutic treatment of acne lesions in subjects afflicted with severe acne. The regimen includes topically applying to a subject's skin, as active ingredients, 0.3% by weight adapalene and 2.5% by weight benzoyl peroxide, combined in a single formula that delivers the active ingredients together. The single formula can for example be applied once or twice daily for a period of 8 to 12 weeks.

Abstract: A method of treating preadolescent acne is described. The method can include administering an effective amount of a pharmaceutical composition that includes a fixed combination of adapalene and benzol peroxide to a preadolescent patient in need thereof. The preadolescent patient can be from age 7 to age 11, and the pharmaceutical composition can include from 0.01% to 2% by weight of adapalene and from 0.1% to 5% by weight by weight of benzol peroxide. Also described, is a composition for use in such a method.