Abstract: A dissoluble microneedle drug delivery system includes a fixation component having an opening window area, and at least two replaceable and/or dissoluble inner matrices fitting into the window area one after another. The fixation component comprises an array of microneedles attached on its base, at least part of the microneedles being configured to fix the delivery system onto skin. The first inner matrix comprises a multitude of microneedles attached on its base, at least part of the microneedles configured to prepare the skin to vaccination by the subsequent second inner matrix. The second inner matrix is a vaccine/immunization matrix configured to replace the first inner matrix and comprising an array of microneedles attached on its base, at least part of the microneedles configured to deliver a vaccination. The system may include a microchannel network within at least one inner matrices for delivery of components regulating dissolution of the microneedles.

Abstract: The disclosure belongs to medical devices and particularly to soluble microneedle patches and small dose medical injection devices for transdermal injections of medical and cosmetic materials to patients. It also belongs to micro-electro-mechanical systems technology (MEMS). The materials can include vitamins, proteins, glycerides, vaccines, mono-, oligo- or polysaccharides, organic acids and its salts, as well as combinations of the said materials and their derivatives. The disclosed micro-needle patch can be used for medical purposes in hospitals, outpatient and home conditions.

Abstract: A dissoluble microneedle drug delivery system includes a fixation component having an opening window area, and at least two replaceable and/or dissoluble inner matrices fitting into the window area one after another. The fixation component comprises an array of microneedles attached on its base, at least part of the microneedles being configured to fix the delivery system onto skin. The first inner matrix comprises a multitude of microneedles attached on its base, at least part of the microneedles configured to prepare the skin to vaccination by the subsequent second inner matrix. The second inner matrix is a vaccine/immunization matrix configured to replace the first inner matrix and comprising an array of microneedles attached on its base, at least part of the microneedles configured to deliver a vaccination. The system may include a microchannel network within at least one inner matrices for delivery of components regulating dissolution of the microneedles.

Abstract: An apparatus for manufacturing a multilayer microneedle patch and a method to manufacture a multilayer microneedle patch is disclosed along with multilayer microneedle patches.

Abstract: An apparatus for manufacturing a multilayer microneedle patch and a method to manufacture a multilayer microneedle patch is disclosed along with multilayer microneedle patches.

Abstract: The disclosure belongs to medical devices and particularly to soluble microneedle patches and small dose medical injection devices for transdermal injections of medical and cosmetic materials to patients. It also belongs to micro-electro-mechanical systems technology (MEMS). The materials can include vitamins, proteins, glycerides, vaccines, mono-, oligo- or polysaccharides, organic acids and its salts, as well as combinations of the said materials and their derivatives. The disclosed micro-needle patch can be used for medical purposes in hospitals, outpatient and home conditions.