Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.

Abstract: A method for locally creating effectively homogeneous or “clean” magnetic field gradients (of high uniformity) for imaging (with NMR, MRI, or spectroscopic MRI) both in in-situ and ex-situ systems with high degrees of inhomogeneous field strength. The method of imaging comprises: a) providing a functional approximation of an inhomogeneous static magnetic field strength B0 (r) at a spatial position r; b) providing a temporal functional approximation of Gshim(t) with i basis functions and j variables for each basis function, resulting in vij variables; c) providing a measured value ?, which is an temporally accumulated dephasing due to the inhomogeneities of B0 (r); and d) minimizing a difference in the local dephasing angle (I) by varying the vij variables to form a set of minimized vij variables. The method requires calibration of the static fields prior to minimization, but may thereafter he implemented without such calibration, may he used in open or closed systems, and potentially portable systems.

Abstract: A system and method for Fourier encoding a nuclear magnetic resonance (NMR) signal is disclosed. A static magnetic field B0 is provided along a first direction. An NMR signal from the sample is Fourier encoded by applying a rotating-frame gradient field BG superimposed on the B0, where the BG comprises a vector component rotating in a plane perpendicular to the first direction at an angular frequency ? in a laboratory frame. The Fourier-encoded NMR signal is detected.

Abstract: This invention relates to the discovery of nucleic acids and proteins associated with baldness and/or hair loss. The identification of these baldness-associated nucleic acids and proteins have uses in predicting the propensity for baldness of an individual and/or in determining the likelihood of baldness in an individual experiencing hair loss. In addition, the nucleic acids of the invention can be used can be used for gene therapy for delaying or stopping the progression of baldness, and/or for reversing baldness.

Abstract: The present invention relates to the discovery of nucleic acids and proteins that are markers for specific normal or cancerous tissues. The identification of these markers has diagnostic uses in detecting cancer in a subject, as well as in determining the tissue of origin for a cancerous cell. These tissue-specific molecules further allow the tissue specific expression of a polynucleotide or protein of interest. In addition, the tissue-specific molecules of the invention have therapeutic applications for targeting compounds to a tissue of interest.

Abstract: This invention relates to the discovery of nucleic acids and proteins associated with the aging processes, such as cell proliferation and senescence. The identification of these aging-associated nucleic acids and proteins have diagnostic uses in detecting the aging status of a cell population as well as applications for gene therapy and the delaying of the aging process.