Patents by Inventor Vasily Makarov

Vasily Makarov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tandem time-of-flight mass spectrometry with non-uniform sampling
    Patent number: 9472390
    Abstract: A method and apparatus are disclosed for parallel all-mass tandem mass spectrometry employing multi-reflecting time-of-flight analyzer for both MS stages, preferably arranged within the same analyzer to secure ultra-high resolution. Sensitivity and speed of TOF-TOF tandem are enhanced by non-redundant multiplexing based on signal sparseness and on avoiding repetitive signal overlaps at multiple repetitions of true fragment signals. Non-redundant matrices of gate and delay timing are constructed by extending orthogonal Latin square matrices. The method is generalized for multiplexing of any multiple repetitive signal sources being sparse either spectrally, or spatially, or in time.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: October 18, 2016
    Assignee: LECO Corporation
    Inventors: Anatoly N. Verenchikov, Vasily Makarov
  • Tandem Time-of-Flight Mass Spectrometry with Non-Uniform Sampling
    Publication number: 20150194296
    Abstract: A method and apparatus are disclosed for parallel all-mass tandem mass spectrometry employing multi-reflecting time-of-flight analyzer for both MS stages, preferably arranged within the same analyzer to secure ultra-high resolution. Sensitivity and speed of TOF-TOF tandem are enhanced by non-redundant multiplexing based on signal sparseness and on avoiding repetitive signal overlaps at multiple repetitions of true fragment signals. Non-redundant matrices of gate and delay timing are constructed by extending orthogonal Latin square matrices. The method is generalized for multiplexing of any multiple repetitive signal sources being sparse either spectrally, or spatially, or in time.
    Type: Application
    Filed: June 18, 2013
    Publication date: July 9, 2015
    Inventors: Anatoly N. Verenchikov, Vasily Makarov