Abstract: TCR identification methods that find particular use in the development of TCR-based cancer therapies are described. The subject TCR screening methods utilize a comprehensive cancer subject database to effectively identify candidate TCRs that recognize a peptide of interest (e.g., a neoantigen) in complex with an HLA allele.

Abstract: A circular loom for continuously weaving fabric with a varying diameter includes a variable diameter weaving ring, independently actuated heddles, and at least one shuttle including a weft insertion arm attached to a linear rail system configured to adjust the position of weft insertion arm based on a diameter of weaving ring. An associated method includes varying the diameter of weaving ring, independently actuating heddles and adjusting the position of weft insertion arm along linear rail system to continuously produce hollow textile products having variable diameters.

Abstract: Exemplary layered double hydroxides (LDHs) may comprise a compound of formula Mg4?yAlXy(OH)2, wherein X is Mn+2, Cu+2, Zn+2, or Fe+2, and 0.01?y?1. Exemplary layered double hydroxide hydrogels (LDH-gels) may comprise a hydrogel and at least one LDH. Exemplary hydrogels may comprise polyethylene (glycol) diacrylate (PEGDA) or polyacrylamide (PAAm). Exemplary LDH-gels may comprise at least one LDH comprising a compound of formula Mg4?yAlXy(OH)2, wherein X is Mn+2, Cu+2, Zn+2, or Fe+2, and 0.01?y?1.

Abstract: A process can include obtaining a plurality of data points each associated with a respective edge device of a fleet of edge devices, each respective edge device associated with an edge site location or edge device asset group. The plurality of data points are stored to a fleet map data catalog and a filtering selection for viewing a filtered subset of the fleet map data catalog is received, indicating a selected geographic view area and selected edge device types from a plurality of edge device types. Data points corresponding to the filtered subset are obtained from the fleet map data catalog using the filtering selection. A fleet map GUI view is generated using the data points corresponding to the filtered subset, the fleet map GUI view comprising a converged geographic map of the selected geographic view area, with data points are rendered at corresponding locations within the converged geographic map.

Abstract: A battery casing includes a first portion including a first planar portion and a bottom portion and a second portion having a second planar portion, a first side portion, and a second side portion, the first portion and the second portion configured to be welded together at (i) a first butt joint extending along the first side portion to join the first side portion to the first planar portion and to the bottom portion at the first side portion, (ii) a second butt joint extending along the second planar portion to join the second planar portion to the bottom portion at the second planar portion, and (iii) a third butt joint extending along the second side portion to join the second side portion to the first planar portion and to the bottom portion at the second side portion.

Abstract: Ultrasonic surgical instruments including a handle housing, a switch frame, and a switch assembly are disclosed. The switch assembly may include a first switch arrangement movably supported on a distal portion of the handle housing and selectively movable relative to a first switch contact supported by the switch frame. The switch assembly may further include a second switch arrangement including a right switch button movably supported on a right side of the handle housing and selectively movable relative to a right switch contact supported by the switch frame, and a left switch button movably supported on a left side of the handle housing and selectively movable relative to a left switch contact supported by the switch frame. The first and second switch arrangements may be configured to be selectively actuatable by a single hand supporting the handle housing.

Abstract: Presented herein are systems and methods for constructing antibody libraries using machine learning to inform sequence selection for inclusion in the library. The techniques include (i) the training and use of machine learning models and statistical models to predict biophysical and biochemical properties from sequences, and (ii) the training and use of machine learning models for predicting developability from sequences, and for generating novel sequences. In certain embodiments, the systems and methods generate libraries of antibodies (and/or antibody-encoding polynucleotides) by specifically designing the libraries with directed sequence and/or length diversity. The resulting libraries are useful, for example, in the development of therapeutic agents.

Abstract: A hydroelectric facility for generating electrical energy from the flow of water circulating in a water network, includes at least one cross-flow pico-turbine mounted on a shaft extending perpendicular to a direction of the water flow, the pico-turbine including a substantially annular blade installed in the water flow in order to generate a mechanical energy of rotation, at least one generating unit, installed outside of the water flow and coupled to the shaft of the pico-turbine in order to transform the mechanical energy of rotation into electrical energy, at least one measurement and control unit, installed outside of the water flow, connected to the generating unit, controlling the distribution of the collected electrical energy as well as the rotation of the pico-turbine depending on the characteristics of the water flow.

Abstract: A device including a speaker and a housing, in which the speaker is configured to generate sound and includes a diaphragm and the housing encloses the speaker and includes a plurality of openings within one portion of the housing. The speaker is positioned within the housing to define a front chamber between the diaphragm and the one portion, and the plurality of openings are sized to collectively generate, with the front chamber, an increased output of the device within a frequency range of an output of the speaker corresponding to an alarm tone. Also provided are methods for assembling a device including a speaker and a housing.

Abstract: Disclosed herein are compositions, methods, and articles of personal protective equipment for use in detoxifying an organophosphate-based agent, wherein the compositions, methods, and articles comprise contacting the organophosphate-based agent with a cocaine esterase, wherein the contacting detoxifies the organophosphate-based agent.

Abstract: Methods for reducing resistivity of metal gapfill include depositing a conformal layer in an opening of a feature and on a field of a substrate with a first thickness of the conformal layer of approximately 10 microns or less, depositing a non-conformal metal layer directly on the conformal layer at a bottom of the opening and directly on the field using an anisotropic deposition process. A second thickness of the non-conformal metal layer on the field and on the bottom of the feature is approximately 30 microns or greater. And depositing a metal gapfill material in the opening of the feature and on the field where the metal gapfill material completely fills the opening without any voids.

Abstract: An exercise mat assembly for improving neck alignment includes a mat, which has a lower face that is positionable upon a substantially horizontal surface. The mat cushions a body of a user who is performing an exercise upon the mat. A pad is attached to an upper face of the mat proximate to a top end of the mat. The pad is formed so as to engage an upper portion and opposite sides of a neck of the user when the user is lying supine upon the mat. The pad thus cushions, supports, and aligns the neck of the user during performance of the exercise.

Abstract: In some examples, a multi-station process tool comprises a plurality of process chambers, each process chamber located at a station of the multi-station process tool; and a RF power path component associated with each station of the multi-station process tool, the RF power path component geometrically positioned and oriented such that, when energized, a symmetric RF power path is created with respect to a center of the multi-station process tool.

Abstract: Devices, systems, and methods for reproducing or simulating a heartbeat pattern in accordance with aspects of the present disclosure. In particular aspects, a device is configured to reproduce a tactile, auditory, and/or visual output representing a heartbeat pattern of a loved one. A user may perceive, during operation, the reproduced heartbeat pattern reproduced by the device. For example, the user may touch the device (e.g., may wrap a hand around the device, may pressed the device against any part of the user's body, etc.), the device may be activated (e.g., by the user's touch) and may reproduce an output (e.g., tactile, auditory, and/or visual) causing the user to perceive the heartbeat pattern. The heartbeat pattern may be one stored in the device, an external device and provided to the device via a link, or generated by the device dynamically during operation.

Abstract: The present disclosure provides oligonucleotides, methods, and compositions for degrading RNA via the lysosomal pathway. Also contemplated are oligonucleotides, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with EXOC2, Ku80, and Task1 in a subject in need thereof.

Abstract: The present invention is directed to a pozzolanic mixture used as a supplementary cementitious material (SCM) comprising an activated clay, a limestone and a setting regulator. Moreover, it is also directed to a cementitious composition comprising said pozzolanic mixture, a clinker and a setting regulator. Finally, the invention is also directed to a concrete comprising the cementitious composition described above, fine aggregate, coarse aggregate and water, optionally the concrete may have other additives.

Abstract: Embodiments can relate to an insulin delivery controller which implements a processor configuration to efficiently attain an insulin delivery target. The insulin delivery controller can include a processor and a memory associated with the processor. The processor can process glucose data received from the memory, including a data representation of glycemic disturbance (d(t)). The processor can determine a glucose rate of change (G?(t)). The processor can generate a command signal to dynamically reshape a glycemic disturbance within a prediction horizon of the insulin delivery controller according to the G?(t). The processor can generate an insulin command signal for an insulin delivery unit to adjust an insulin delivery dosage amount and/or an insulin delivery dosage rate.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for determining an number of slots for achieving a desired reach specified in a media content delivery schedule. The system, apparatus, article of manufacture, method, and/or computer program product aspects is designed with a simulation framework tuned to predict an estimate the needed number of slots based on a reach specified in the delivery schedule.

Abstract: Embodiments are provided that include generating, by an inter-modal predictor, predicted second-mode information for a first text-based record based on first-mode information of the first text-based record. Embodiments also include generating a first value by evaluating a first loss function that is based on a first difference between the second-mode information of the first text-based record as predicted and as observed; updating the inter-modal predictor based on the first value; generating, by the updated inter-modal predictor, predicted second-mode information for a second text-based record in the database based on first-mode information of the second text-based record; generating a second value by evaluating a second loss function that is based on a second difference between the second-mode information of the second text-based record as predicted and as observed; and training an operational model based on the second value.