Patents by Inventor Vasulinga T. Ravikumar

Vasulinga T. Ravikumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of oligomeric phosphite, phosphodiester, phosphorothioate and phosphorodithioate compounds
    Patent number: 5859232
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, and phosphorodithioate covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: January 12, 1999
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventor: Vasulinga T. Ravikumar
  • Protecting group for synthesizing oligonucleotide analogs
    Patent number: 5783690
    Abstract: A 2-N-amidoethyl protected nucleoside analog phosphoramidite of formula (1): ##STR1## is useful in the synthesis of a wide variety of oligonucleotide analogs. Coupling yields with phosphoramidite (1) in solution or solid phase oligonucleotide analog synthesis are high and the 2-N-amidoethyl protecting group can be removed easily under standard conditions.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: July 21, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Daniel C. Capaldi, Vasulinga T. Ravikumar, Douglas L. Cole
  • Protecting group for synthesizing oligonucleotide analogs
    Patent number: 5760209
    Abstract: Nucleoside analog phosphoramidites are provided in which the 3'-hydroxyl group is protected with an 2-N-amidoethyl group. The 2-N-amidoethyl protected nucleoside analogs are useful in the synthesis of a wide variety of oligonucleotide analogs. Coupling yields with the protected phosphoramidites in solution or solid phase oligonucleotide analog synthesis are high and the 2-N-amidoethyl group can be removed easily under standard conditions.
    Type: Grant
    Filed: March 3, 1997
    Date of Patent: June 2, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Daniel C. Capaldi, Vasulinga T. Ravikumar, Douglas L. Cole
  • Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
    Patent number: 5705621
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, and phosphorodithioate covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: November 17, 1995
    Date of Patent: January 6, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventor: Vasulinga T. Ravikumar
  • Process for preparing oligonucleotides using silyl-containing diamino phosphorous reagents
    Patent number: 5614621
    Abstract: Synthetic processes are provided wherein substituted silylalkyl phosphoramidites serve as coupling reagents for preparing phosphate, phosphorothioate, and other phosphorous-containing covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: July 29, 1993
    Date of Patent: March 25, 1997
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Dennis Mulvey, Douglas L. Cole, Phillip D. Cook