Patents by Inventor Vasyl Andrushko
Vasyl Andrushko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11897843Abstract: The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, as in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrate and crystalline (S)-3-aminopiperidine-dihydrochloride-monohydrate.Type: GrantFiled: September 9, 2022Date of Patent: February 13, 2024Inventors: Karl Reuter, Tobias Wedel, Viktor Meier, Mark Kantor, Vasyl Andrushko, Florian Stolz
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Publication number: 20230391704Abstract: The present invention relates to triarylmethane compounds of the formula (I), which suitable as monomers for preparing thermoplastic resins having beneficial optical properties and which can be used for producing optical devices. R1 , R2 are e.g. hydrogen; Y is an alkylene group having 2, 3 or 4 carbon atoms, Ar is selected from mono- or polycyclic aryl and mono- or polycyclic hetaryl; X1, X2, X3, X4 are CH, C—Rx or N, provided that in each ring at most two of X1, X2, X3, X4 are N; Rx is e.g. halogen, CN or CH?CH2. The invention also relates to thermoplastic resins comprising a polymerized unit of the compound of formula (I).Type: ApplicationFiled: August 8, 2023Publication date: December 7, 2023Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.Inventors: Karl REUTER, Vasyl ANDRUSHKO, Mark KANTOR, Florian STOLZ, Munenori SHIRATAKE, Kentaro ISHIHARA, Koji HIROSE, Shinya IKEDA, Noriyuki KATO, Mitsuteru KONDO, Shoko MURATA, Kensuke OSHIMA
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Patent number: 11760712Abstract: The present invention relates to triarylmethane compounds of the formula (I), which suitable as monomers for preparing thermoplastic resins having beneficial optical properties and which can be used for producing optical devices. R1, R2 are e.g. hydrogen; Y is an alkylene group having 2, 3 or 4 carbon atoms, Ar is selected from mono- or polycyclic aryl and mono- or polycyclic hetaryl; X1, X2, X3, X4 are CH, C—Rx or N, provided that in each ring at most two of X1, X2, X3, X4 are N; Rx is e.g. halogen, CN or CH?CH2. The invention also relates to thermoplastic resins comprising a polymerized unit of the compound of formula (I).Type: GrantFiled: February 1, 2019Date of Patent: September 19, 2023Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Karl Reuter, Vasyl Andrushko, Mark Kantor, Florian Stolz, Munenori Shiratake, Kentaro Ishihara, Koji Hirose, Shinya Ikeda, Noriyuki Kato, Mitsuteru Kondo, Shoko Murata, Kensuke Oshima
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Publication number: 20230008387Abstract: The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, as in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrateand crystalline (S)-3-aminopiperidine-dihydrochloride-monohydrate.Type: ApplicationFiled: September 9, 2022Publication date: January 12, 2023Applicant: REUTER CHEMISCHE APPARATEBAU KGInventors: Karl Reuter, Tobias Wedel, Viktor Meier, Mark Kantor, Vasyl Andrushko, Florian Stolz
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Patent number: 11472770Abstract: The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, as in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrateand crystalline (S)-3-aminopiperidine-dihydrochloride-monohydrate.Type: GrantFiled: September 23, 2019Date of Patent: October 18, 2022Inventors: Karl Reuter, Tobias Wedel, Viktor Meier, Mark Kantor, Vasyl Andrushko, Florian Stolz
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Publication number: 20220243008Abstract: Crystalline solvate forms and amorphous forms of 6,6?-diphenyl-2,2?-bis(2-hydroxyethoxy)-1,1?-binaphthyl, where the organic solvent is selected from methanol, toluene, and methyl ethyl ketone, and an amorphous form of 6,6?-diphenyl-2,2?-bis(2-hydroxyethoxy)-1,1?-binaphthyl having a purity of at least 99.0% by weight, based on organic matter. Thermoplastic resins containing a structural unit derived from 6,6?-diphenyl-2,2?-bis(2-hydroxyethoxy)-1,1?-binaphthyl. Optical lenses containing the thermoplastic resins containing a structural unit derived from 6,6?-diphenyl-2,2?-bis(2-hydroxyethoxy)-1,1?-binaphthyl.Type: ApplicationFiled: January 28, 2022Publication date: August 4, 2022Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.Inventors: Shinya IKEDA, Noriyuki KATO, Manabu HIRAKAWA, Karl REUTER, Vasyl ANDRUSHKO, Mark KANTOR, Florian STOLZ
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Publication number: 20220145004Abstract: Provided is a thermoplastic resin including constituent units represented by general formula (1). (In formula (1), R1 and R2 each independently represent: a hydrogen atom; a fluorine atom; a chlorine atom; a bromine atom; an iodine atom; a C1-6 alkyl group; a monocyclic or polycyclic C6-36 aryl group; a monocyclic or polycyclic heteroaryl group having 5-36 ring atoms, 1, 2, 3, or 4 of the ring atoms being selected from nitrogen, sulfur, and oxygen, and the other ring atoms being carbon in the heteroaryl group; a C2-6 alkenyl group; a C1-6 alkoxy group; or a C7-17 aralkyl group. In formula (1), X, a, and bare each as described in the present specification.Type: ApplicationFiled: February 27, 2020Publication date: May 12, 2022Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.Inventors: Shinya IKEDA, Noriyuki KATO, Manabu HIRAKAWA, Karl REUTER, Vasyl ANDRUSHKO, Mark KANTOR, Florian STOLZ
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Publication number: 20210371367Abstract: The present invention relates to triarylmethane compounds of the formula (I), which suitable as monomers for preparing thermoplastic resins having beneficial optical properties and which can be used for producing optical devices. R1, R2 are e.g. hydrogen; Y is an alkylene group having 2, 3 or 4 carbon atoms, Ar is selected from mono- or polycyclic aryl and mono- or polycyclic hetaryl; X1, X2, X3, X4 are CH, C—Rx or N, provided that in each ring at most two of X1, X2, X3, X4 are N; Rx is e.g. halogen, CN or CH?CH2. The invention also relates to thermoplastic resins comprising a polymerized unit of the compound of formula (I).Type: ApplicationFiled: February 1, 2019Publication date: December 2, 2021Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.Inventors: Karl Reuter, Vasyl Andrushko, Mark Kantor, Florian Stolz, Munenori Shiratake, Kentaro Ishihara, Koji Hirose, Shinya Ikeda, Noriyuki Kato, Mitsuteru Kondo, Shoko Suzuki, Kensuke Oshima
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Publication number: 20210340317Abstract: The present invention relates to compounds of the formula (I), which are suitable as monomers for preparing thermoplastic resins having beneficial optical properties and which can be used for producing optical devices. In Formula (I), A1, A2 are selected from mono- or bicyclic aromatic radicals and mono- or bicyclic heteroaromatic radicals; X represents e.g. a single bond, O, NH, CR6R7; Y is e.g. absent or represents a single bond, O, NH, CR8R9; R1, R2 are hydrogen, a radical Ar? or a radical Ra; R3 is Alk, O-Alk?-, O-Alk?-[O-Alk?]o, O—CH2—Ar—C(O)—, O—C(O)—Ar—C(O)— or O-Alk-C(O)—, where in the last five moieties the left O is bound to A1 and A2, respectively; m, n are 0, 1 or 2; o is an integer from 1 to 10; R4, R5 are e.g. selected from CN and a radical Ra; R6, R8 are e.g. selected from hydrogen, a radical Ar? and a radical Ra; R7, R9 are e.g. selected from hydrogen, C1-C4-alkyl and a radical Ar?; Ra is selected from the group consisting of C?C—R11 and Ar—C?C—R11; R11 is e.g.Type: ApplicationFiled: October 18, 2019Publication date: November 4, 2021Inventors: Karl REUTER, Vasyl ANDRUSHKO, Mark KANTOR, Florian STOLZ, Philipp KOSCHKER, Munenori SHIRATAKE, Kentaro ISHIHARA, Koji HIROSE, Shinya IKEDA, Noriyuki KATO, Mitsuteru KONDO, Shoko SUZUKI, Kensuke OSHIMA
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Patent number: 11072573Abstract: The present invention relates to binaphthyl compounds of the formula (I), which are suitable as monomers for preparing polycarbonate resins having beneficial optical properties and which can be used for producing optical lenses: Formula (I) where X is C2-C4-alkandiyl or C1-C4-alkandiyl-C(O)—, where C(O) is bound to the oxygen atom of the hydroxyl group and where C2-C4-alkandiyl or C1-C4-alkandiyl, respectively, are unsubstituted or carry a phenyl ring; R and R? are identical or different and selected from mono or polycyclic aryl having from 6 to 36 carbon atoms and mono- or polycyclic hetaryl having a total of 5 to 36 atoms, which are ring members, where 1, 2, 3 or 4 of these atoms are selected from nitrogen, sulfur and oxygen, while the remainder of these atoms are carbon atoms, where mono- or polycyclic aryl and mono- or polycyclic hetaryl are unsubstituted or carry 1 or 2 radicals Ra, which are selected from the group consisting of CN, CH3, OCH3, O-phenyl, O-naphthyl, S-phenyl, S-naphthyl, CI or F; and, ifType: GrantFiled: August 29, 2018Date of Patent: July 27, 2021Assignee: Reuter Chemische Apparatebau E.K.Inventors: Karl Reuter, Vasyl Andrushko, Mark Kantor, Florian Stolz, Noriyuki Kato, Mitsuteru Kondo, Munenori Shiratake, Kentaro Ishihara, Shinya Ikeda, Shoko Suzuki, Koji Hirose, Kensuke Oshima, Shuya Nagayama
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Publication number: 20200354299Abstract: The present invention relates to binaphthyl compounds of the formula (I), which are suitable as monomers for preparing polycarbonate resins having beneficial optical properties and which can be used for producing optical lenses: Formula (I) where X is C2-C4-alkandiyl or C1-C4-alkandiyl-C(O)—, where C(O) is bound to the oxygen atom of the hydroxyl group and where C2-C4-alkandiyl or C1-C4-alkandiyl, respectively, are unsubstituted or carry a phenyl ring; R and R? are identical or different and selected from mono or polycyclic aryl having from 6 to 36 carbon atoms and mono- or polycyclic hetaryl having a total of 5 to 36 atoms, which are ring members, where 1, 2, 3 or 4 of these atoms are selected from nitrogen, sulfur and oxygen, while the remainder of these atoms are carbon atoms, where mono- or polycyclic aryl and mono- or polycyclic hetaryl are unsubstituted or carry 1 or 2 radicals Ra, which are selected from the group consisting of CN, CH3, OCH3, O-phenyl, O-naphthyl, S-phenyl, S-naphthyl, CI or F; and, ifType: ApplicationFiled: August 29, 2018Publication date: November 12, 2020Inventors: Karl REUTER, Vasyl ANDRUSHKO, Mark KANTOR, Florian STOLZ, Noriyuki KATO, Mitsuteru KONDO, Munenori SHIRATAKE, Kentaro ISHIHARA, Shinya IKEDA, Shoko SUZUKI, Koji HIROSE, Kensuke OSHIMA, Shuya NAGAYAMA
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Publication number: 20200087257Abstract: The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, as in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrateand crystalline (S)-3-aminopiperidine-dihydrochloride-monohydrate.Type: ApplicationFiled: September 23, 2019Publication date: March 19, 2020Applicant: REUTER CHEMISCHE APPARATEBAU KGInventors: Karl Reuter, Tobias Wedel, Viktor Meier, Mark Kantor, Vasyl Andrushko, Florian Stolz
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Patent number: 10464898Abstract: The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, and in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrate and crystalline (S)-3-aminopiperidine-di-hydrochloride-monohydrate.Type: GrantFiled: February 19, 2014Date of Patent: November 5, 2019Assignee: Reuter Chemische Apparatebau KGInventors: Karl Reuter, Tobias Wedel, Viktor Meier, Mark Kantor, Vasyl Andrushko, Florian Stolz
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Publication number: 20160251311Abstract: The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, and in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrate and crystalline (S)-3-aminopiperidine-di-hydrochloride-monohydrate.Type: ApplicationFiled: February 19, 2014Publication date: September 1, 2016Applicant: REUTER CHEMISCHE APPARATEBAU KGInventors: Karl Reuter, Tobias Wedel, Viktor Meier, Mark Kantor, Vasyl Andrushko, Florian Stolz
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Publication number: 20160068486Abstract: The present invention relates to a process for preparing enantiomerically enriched 3-hydroxymethylpiperidine and in particular of the S-enantiomer of (S)-3-hydroxymethyl-piperidine in high chemical and optical purity. The invention also relates to extremely pure (S)-3-hydroxymethylpiperidine and (R)-3-hydroxymethylpiperidine.Type: ApplicationFiled: April 22, 2014Publication date: March 10, 2016Applicant: REUTER CHEMISCHE APPARATEBAU KGInventors: Karl Reuter, Tobias Wedel, Vasyl Andrushko, Christian Wiegand, Florian Stolz
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Publication number: 20110295005Abstract: The present invention relates to a process for preparing pyrimidine derivatives of the formula V, in particular as intermediates useful for preparing pyrimidine derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, such as HMG-CoA reductase inhibitors, e.g. rosuvastatin.Type: ApplicationFiled: August 19, 2008Publication date: December 1, 2011Applicant: Ratiopharm GmbHInventors: Armin Boerner, Gerd Koenig, Natalia Andrushko, Vasyl Andrushko
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Publication number: 20110065920Abstract: The present invention relates to a process for preparing pentanoic diacid derivatives useful for preparing pyrimidine derivatives, in particular as intermediates useful for preparing pyrimidine derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, such as HMG-CoA reductase inhibitors, e.g. rosuvastatin.Type: ApplicationFiled: August 27, 2008Publication date: March 17, 2011Applicant: ratiopharm GmbHInventors: Armin Boerner, Gerd Koenig, Natalia Andrushko, Vasyl Andrushko