Patents by Inventor VATCHE AGOPIAN

VATCHE AGOPIAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenotypic profiling of hepatocellular carcinoma circulating tumor cells for treatment selection
    Patent number: 11385232
    Abstract: Methods and kits for detecting hepatocellular carcinoma recurrence or metastasis, and of measuring markers of hepatocellular carcinoma, including markers of hepatocellular carcinoma recurrence or metastasis, in a blood sample obtained from a subject by (a) isolating circulating tumor cells (CTCs) by contacting a blood sample obtained from the subject with a set of capture antibodies, wherein the capture antibodies specifically bind asialoglycoprotein receptor (ASGPR), Glypican-3, and epithelial cell adhesion molecule (EpCAM); (b) contacting the isolated CTCs with an antibody that specifically binds vimentin; and (c) measuring the number of vimentin-positive CTC.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: July 12, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Vatche Agopian, Hsian-Rong Tseng, Shuang Hou
  • PHENOTYPIC PROFILING OF HEPATOCELLULAR CARCINOMA CIRCULATING TUMOR CELLS FOR TREATMENT SELECTION
    Publication number: 20200182877
    Abstract: Methods and kits for detecting hepatocellular carcinoma recurrence or metastasis, and of measuring markers of hepatocellular carcinoma, including markers of hepatocellular carcinoma recurrence or metastasis, in a blood sample obtained from a subject by (a) isolating circulating tumor cells (CTCs) by contacting a blood sample obtained from the subject with a set of capture antibodies, wherein the capture antibodies specifically bind asialoglycoprotein receptor (ASGPR), Glypican-3, and epithelial cell adhesion molecule (EpCAM); (b) contacting the isolated CTCs with an antibody that specifically binds vimentin; and (c) measuring the number of vimentin-positive CTC.
    Type: Application
    Filed: August 31, 2018
    Publication date: June 11, 2020
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: VATCHE AGOPIAN, HSIAN-RONG TSENG, Shuang HOU