Patents by Inventor Vaughn E. Ostland

Vaughn E. Ostland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoassay tracer reagents and methods for measuring the amount of native human bioactive hepcidin
    Publication number: 20120202229
    Abstract: The invention provides compositions and methods for measuring human serum hepcidin levels. The invention provides methods for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal.
    Type: Application
    Filed: February 2, 2012
    Publication date: August 9, 2012
    Applicant: INTRINSIC LIFESCIENCES LLC
    Inventors: Xavier LAUTH, Mark E. WESTERMAN, Vaughn E. OSTLAND, Jason A. STANNARD, Michael W. PENNINGTON
  • COMPOSITIONS AND METHODS FOR MEASURING LEVELS OF BIOACTIVE HUMAN HEPCIDIN
    Publication number: 20110183362
    Abstract: The invention provides compositions and methods for measuring human serum hepcidin levels. The invention provides methods for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal.
    Type: Application
    Filed: June 10, 2010
    Publication date: July 28, 2011
    Applicant: INTRINSIC LIFESCIENCES LLC
    Inventors: Xavier LAUTH, Mark E. WESTERMAN, Vaughn E. OSTLAND, Jason A. STANNARD, Michael W. PENNINGTON
  • Compositions and methods for measuring levels of bioactive human hepcidin
    Patent number: 7745162
    Abstract: The invention provides compositions and methods for measuring human serum hepcidin levels. The invention provides methods for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal.
    Type: Grant
    Filed: November 11, 2008
    Date of Patent: June 29, 2010
    Assignee: Intrinsic Lifesciences
    Inventors: Xavier Lauth, Mark E. Westerman, Vaughn E. Ostland, Jason A. Stannard, Michael W. Pennington
  • Methods for measuring levels of bioactive human hepcidin
    Patent number: 7723063
    Abstract: The present invention concerns a method for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal; a method for measuring the level of hepcidin gene expression in a vertebrate animal; and a method for regulating the production of native, bioactive hepcidin in a vertebrate animal in vivo. The present invention also concerns an antibody or fragment thereof that specifically binds to a continuous, discontinuous, and/or conformational epitope of a mature and bioactive hepcidin folded as in the native configuration; and a pharmaceutical composition that includes the antibody or a hepcidin polypeptide and that provides antimicrobial, agonistic, or antagonistic activities in vivo in a vertebrate animal.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: May 25, 2010
    Assignee: Intrinsic Lifesciences
    Inventors: Xavier Lauth, Mark E. Westerman, Vaughn E. Ostland, Jason A. Stannard, Michael W. Pennington
  • COMPOSITIONS AND METHODS FOR MEASURING LEVELS OF BIOACTIVE HUMAN HEPCIDIN
    Publication number: 20090215095
    Abstract: The invention provides compositions and methods for measuring human serum hepcidin levels. The invention provides methods for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal.
    Type: Application
    Filed: November 11, 2008
    Publication date: August 27, 2009
    Applicant: Mark E. Westerman, Ph.D.
    Inventors: Xavier Lauth, Mark E. Westerman, Vaughn E. Ostland, Jason A. Stannard, Michael W. Pennington
  • Streptococcus Iniae Phosphoglucomutase is a Virulence Factor and Target for Vaccine Development
    Publication number: 20090162401
    Abstract: The present invention relates generally to the identification of virulence factors from Streptococcus iniae. Specifically, the present invention relates to the identification, characterization and sequencing of a gene for phosphoglucomutase gene, and to a live attenuated strain of S. iniae deficient in phosphoglucomutase useful as a vaccine in aquatic species, such as fish.
    Type: Application
    Filed: February 17, 2006
    Publication date: June 25, 2009
    Inventors: John T. Buchanan, Jason A. Stannard, Xavier Lauth, Vaughn E. Ostland, Mark E. Westerman, Victor Nizet