Patents by Inventor Velizar Tchernev
Velizar Tchernev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080044843Abstract: Detection of expression of biomarkers (e.g., protein analytes) whose regulation is perturbed in COPD patients can be used to diagnose COPD, to confirm a diagnosis of COPD, and to assess or prognose progression of COPD. Test substances can be screened for the ability to affect levels of protein analyte expression, thereby identifying potential anti-COPD drugs.Type: ApplicationFiled: December 21, 2006Publication date: February 21, 2008Inventors: Lorah Perlee, Martin Sorette, Velizar Tchernev, Serguel Lejnine, Stephen Kingsmore
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Publication number: 20070225206Abstract: Methods are provided for evaluating osteoarthritis (OA), for example for diagnosing OA, to confirm a diagnosis of OA, to assess or prognose progression of OA, determining the severity of a subject who has OA, and determining a subject's risk of developing OA in the future, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes determining an amount of activity (such as an amount of protein present or an amount of expression) of OA risk-related molecules, such as soluble vascular adhesion protein 1 (sVAP-1) or interleukin-15 (IL-15). Also provided are methods of identifying one or more compounds that alter the activity of an OA-related molecule, thereby identifying potential anti-osteoarthritis drugs.Type: ApplicationFiled: August 12, 2005Publication date: September 27, 2007Inventors: Shari Ling, Lorah Perlee, Velizar Tchernev, Serguei Lejnine, Dhavalkumar Patel, Luigi Ferrucci, Ming Zhan
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Publication number: 20060111561Abstract: Disclosed are novel proteins and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the proteins and polynucleotides, as well as methods for using same.Type: ApplicationFiled: August 31, 2005Publication date: May 25, 2006Inventors: Valerie Gerlach, Elma Fernandes, Richard Shimkets, Meera Patturajan, Vladimir Gusev, Stacie Navara, Velizar Tchernev, David Anderson, Xiaojia Guo, Luca Rastelli, Mei Zhong, Muralidhara Padigaru
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Publication number: 20060009634Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: December 21, 2004Publication date: January 12, 2006Inventors: Ramesh Kekuda, John Alsobrook, Velizar Tchernev, Xiaohong Liu, Kimberly Spytek, Meera Patturajan, William Grosse, Denise Lepley, Catherine Burgess, Corine Vernet, Li Li, Linda Gorman, Shlomit Edinger, Paul Sciore, Karen Ellerman, Uriel Malyankar, Mark Rothenberg, David Stone, Ferenc Boldog, Xiaojia Guo, Suresh Shenoy, David Anderson, Muralidhara Padigaru, Raymond Taupier, Charles Miller, Andrew Eisen
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Publication number: 20050196817Abstract: Biomarkers for sepsis and resulting mortality can be detected by assaying blood samples. Changes in the concentration of the biomarkers can be used to indicate sepsis, risk of sepsis, progression of sepsis, remission from sepsis, and risk of mortality. Changes can be evaluated relative to data sets, natural or synthetic or semisynthetic control samples, or patient samples collected at different time points. Some biomarkers' concentrations are elevated during disease and some are depressed. These are termed informative biomarkers. Some biomarkers are diagnostic in combination with others. Individual biomarkers may be weighted when used in combinations. Biomarkers can be assessed in individual, isolated or assays, in parallel assays, or in single-pot assays.Type: ApplicationFiled: January 20, 2004Publication date: September 8, 2005Applicant: Molecular Staging Inc.Inventors: Stephen Kingsmore, Serguei Lejnine, Mark Driscoll, Velizar Tchernev
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Publication number: 20050053930Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: June 3, 2003Publication date: March 10, 2005Inventors: David Anderson, Ferenc Boldog, Catherine Burgess, Stacie Casman, Shlomit Edinger, Andrew Eisen, Karen Ellerman, Valerie Gerlach, Linda Gorman, Xiaojia Guo, Vladimir Gusev, Weizhen Ji, Li Li, John MacDougall, Uriel Malyankar, Isabelle Millet, Tatiana Ort, Muralidhara Padigaru, Sudhirdas Prayaga, Meera Patturajan, Carol Pena, John Peyman, Daniel Rieger, Mark Rothenberg, Paul Sciore, Suresh Shenoy, Glennda Smithson, Kimberly Spytek, David Stone, Raymond Taupier, Velizar Tchernev, Corine Vernet, Edward Voss, Bryan Zerhusen, Mei Zhong
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Publication number: 20040048248Abstract: Disclosed herein are novel human nucleic acid sequences which encode endozepine-like polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving this novel human endozepine-like nucleic acid and protein.Type: ApplicationFiled: February 27, 2002Publication date: March 11, 2004Inventors: Sudhirdas K. Prayaga, Richard A. Shimkets, Kumud Majumder, Andrew Eisen, Corine A.M. Vernet, Steven K. Spaderna, Jason Baumgartner, Linda Gorman, Vladimir Gusev, Muralidhara Padigaru, Meera Patturajan, Velizar Tchernev, Li Li
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Publication number: 20040022781Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.Type: ApplicationFiled: December 31, 2001Publication date: February 5, 2004Inventors: Kimberly A. Spytek, Li Li, Adam R. Wolenc, Corine Vernet, Andrew J. Eisen, Xiaohong Liu, Uriel M. Malyankar, Richard A. Shimkets, Velizar Tchernev, Steven K. Spaderna, Linda Gorman, Ramesh Kekuda, Meera Patturajan, Vladimir Y. Gusev, Esha A. Gangolli, Xiaojia (Sasha) Guo, Suresh G. Shenoy, Luca Rastelli, Stacie J. Casman, Ferenc L. Boldog, Catherine E. Burgess, Shlomit R. Edinger, Karen Ellerman, Erik Gunther, Glennda Smithson, Isabelle Millet, John R. MacDougall
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Publication number: 20040009503Abstract: Human extracellular ribonucleases (RNases) are widely distributed in various organs and body fluids and together with other members of the mammalian RNase A superfamily. In addition to their RNase activity, several RNases have been shown to have special biological actions, i.e., antitumor, antiviral and angiogenic properties. However, the molecular mechanisms of such activities are unclear. Using protein microarrays amplified rolling circle amplification (RCA), we investigated the effects of EDN (Rnase 2), ECP (Rnase 3) and RNase 1 on leukocytes cytokine production. We measured the levels of 78 different cytokines and growth factors in culture supernatants to determine the cytokine profiles of cells treated with different combinations of RNases and RNase inhibitors.Type: ApplicationFiled: March 26, 2003Publication date: January 15, 2004Applicant: Molecular Staging, Inc.Inventors: Qin Fu, Velizar Tchernev, Ebenezer Satyaraj, Dhavalkumar D. Patel, Stephen F. Kingsmore, Barry Schweitzer
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Publication number: 20030149237Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: June 27, 2001Publication date: August 7, 2003Inventors: Corine Vernet, Velizar Tchernev, Meera Patturajan, Uriel M. Malyankar, Vladimir Gusev, John L. Herrmann, John R. MacDougall, Luca Rastelli, Haihong Zhong, Kimberly A. Spytek, Suresh Shenoy, Valerie L. Gerlach, Esha A. Gangolli, David J. Stone, Glennda Smithson
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Publication number: 20030138926Abstract: The present invention provides novel polypeptides, termed PTMAX polypeptides, as well as polynucleotides encoding PTMAX polypeptides and antibodies that immunospecifically bind to PTMAX or a derivative, variant, mutant, or fragment of the PTMAX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the PTMAX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.Type: ApplicationFiled: June 15, 2001Publication date: July 24, 2003Inventors: Sudhirdas K. Prayaga, Corine Vernet, Richard A. Shimkets, Catherine E. Burgess, Kimberly A. Spytek, Velizar Tchernev
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Publication number: 20020090692Abstract: The present invention provides novel polypeptides, termed PTMAX polypeptides, as well as polynucleotides encoding PTMAX polypeptides and antibodies that immunospecifically bind to PTMAX or a derivative, variant, mutant, or fragment of the PTMAX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the PTMAX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.Type: ApplicationFiled: October 10, 2001Publication date: July 11, 2002Inventors: Sudhirdas K. Prayaga, Corine Vernet, Richard A. Shimkets, Catherine E. Burgess, Kimberly A. Spytek, Velizar Tchernev, Valerie Gerlach, John R. MacDougall, Isabelle Millet, David J. Stone, Karen Ellerman
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Publication number: 20020065405Abstract: The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.Type: ApplicationFiled: January 16, 2001Publication date: May 30, 2002Inventors: Muralidhara Padigaru, Sudhirdas Prayaga, Raymond J. Taupier, Vishnu Mishra, Velizar Tchernev, Kimberly Spytek, Li Li