Patents by Inventor Veljko NIKOLIN

Veljko NIKOLIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOGENIC COMPOSITIONS AND VACCINES COMPRISING AFRICAN SWINE FEVER VIRUS PEPTIDES AND PROTEINS AND USES THEREOF
    Publication number: 20230277648
    Abstract: The present invention relates to African swine fever virus (ASFV) peptides and/or polypeptides as well as immunogenic fragments thereof, corresponding encoding AFSV oligonucleotides and/or polynucleotides as well as immunogenic fragments thereof, immunogenic compositions, vaccines and uses thereof.
    Type: Application
    Filed: December 16, 2022
    Publication date: September 7, 2023
    Inventors: Veljko NIKOLIN, Egbert Siegfried MUNDT, Fernando Rodriguez GONZALEZ, Laia Bosch CAMOS, Javier Alonso COLLADO MIGUENS
  • Paramyxoviridae expression system
    Patent number: 11730805
    Abstract: The present invention relates to the field of (vector) vaccines, and especially to an enhanced arrangement of nucleotide sequences for expressing a Paramyxoviridae virus containing an exogenous gene of interest. The present invention further concerns related expression cassettes and vectors, which are suitable to express genes of interest, especially antigen encoding sequences. The viral vectors of the present invention are useful for producing an immunogenic composition or vaccine.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: August 22, 2023
    Inventors: Veljko Nikolin, Alissa Benter, Andreas Gallei
  • Immunogenic compositions and vaccines comprising African swine fever virus peptides and proteins and uses thereof
    Patent number: 11628214
    Abstract: The present invention relates to African swine fever virus (ASFV) peptides and/or polypeptides as well as immunogenic fragments thereof, corresponding encoding AFSV oligonucleotides and/or polynucleotides as well as immunogenic fragments thereof, immunogenic compositions, vaccines and uses thereof.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: April 18, 2023
    Inventors: Veljko Nikolin, Egbert Siegfried Mundt, Fernando Rodriguez Gonzalez, Laia Bosch Camos, Javier Alonso Collado Miguens
  • Modified PEDV spike protein
    Patent number: 11464852
    Abstract: The present invention relates to a nucleic acid molecule encoding a modified porcine epidemic diarrhea virus (PEDV) spike (S) protein and the PEDV (S) protein thereof. Further, the present invention relates to immunogenic compositions comprising said modified PEDV spike protein and methods for immunizing a subject comprising the administration of said immunogenic composition to a subject.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: October 11, 2022
    Inventors: Veljko Nikolin, Andreas Gallei
  • Recombinant viral vector systems expressing exogenous feline paramyxovirus genes and vaccines made therefrom
    Patent number: 11033616
    Abstract: The present invention relates to exogenous feline paramyxovirus genes, which are expressed from recombinant viral vector systems.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: June 15, 2021
    Inventors: Hervé Poulet, Veljko Nikolin, Abraham Johannes De Smit, Teshome Mebatsion
  • Intranasal vector vaccine against porcine epidemic diarrhea
    Patent number: 10905758
    Abstract: The present invention relates to the field of (vector) vaccines, and especially to a canine distemper virus (CDV) vector comprising a heterologous nucleotide sequence which encodes a porcine epidemic diarrhea virus (PEDV) antigen. Said PEDV antigen is preferably a PEDV spike (S) protein. The viral vector of the present invention is useful for producing an immunogenic composition or vaccine for intranasally immunizing sows, and thereby protecting piglets, suckled by said sows, against the clinical signs associated with a PEDV infection.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: February 2, 2021
    Inventors: Veljko Nikolin, Andreas Gallei
  • IMMUNOGENIC COMPOSITIONS AND VACCINES COMPRISING AFRICAN SWINE FEVER VIRUS PEPTIDES AND PROTEINS AND USES THEREOF
    Publication number: 20200306360
    Abstract: The present invention relates to African swine fever virus (ASFV) peptides and/or polypeptides as well as immunogenic fragments thereof, corresponding encoding AFSV oligonucleotides and/or polynucleotides as well as immunogenic fragments thereof, immunogenic compositions, vaccines and uses thereof.
    Type: Application
    Filed: March 26, 2020
    Publication date: October 1, 2020
    Inventors: Veljko NIKOLIN, Egbert Siegfried MUNDT, Fernando Rodriguez GONZALEZ, Laia Bosch CAMOS, Javier Alonso COLLADO MIGUENS
  • PARAMYXOVIRIDAE EXPRESSION SYSTEM
    Publication number: 20200276298
    Abstract: The present invention relates to the field of (vector) vaccines, and especially to an enhanced arrangement of nucleotide sequences for expressing a Paramyxoviridae virus containing an exogenous gene of interest. The present invention further concerns related expression cassettes and vectors, which are suitable to express genes of interest, especially antigen encoding sequences. The viral vectors of the present invention are useful for producing an immunogenic composition or vaccine.
    Type: Application
    Filed: September 20, 2018
    Publication date: September 3, 2020
    Inventors: Veljko NIKOLIN, Alissa BENTER, Andreas GALLEI
  • RECOMBINANT VIRAL VECTOR SYSTEMS EXPRESSING EXOGENOUS FELINE PARAMYXOVIRUS GENES AND VACCINES MADE THEREFROM
    Publication number: 20200206339
    Abstract: The present invention relates to exogenous feline paramyxovirus genes, which are expressed from recombinant viral vector systems.
    Type: Application
    Filed: February 20, 2019
    Publication date: July 2, 2020
    Inventors: Hervé POULET, Veljko NIKOLIN, Abraham Johannes DE SMIT, Teshome MEBATSION
  • Swine influenza vaccine
    Patent number: 10626414
    Abstract: The present invention relates to Equine Herpes Virus (EHV) vectors comprising at least one exogenous antigen encoding sequence relating to a pathogen infecting food producing animals, wherein said exogenous antigen encoding sequence is inserted into an insertion site, preferably ORF70, and said exogenous antigen encoding sequence is operably linked to a promoter sequence, preferably the promoter sequence comprising 4pgG600 (SEQ ID NO:1) or 4pMCP600 (SEQ ID NO:2) or the complementary nucleotide sequences thereof or a functional fragment or a functional derivative thereof or the complementary nucleotide sequences thereof. Furthermore, the present invention relates to methods for immunizing a food producing animal comprising administering to such food producing animal an immunogenic composition comprising embodiments of the present invention. Moreover, the present invention relates to methods for the treatment or prophylaxis of clinical signs caused by swine influenza virus in a food producing animal.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: April 21, 2020
    Inventors: Andreas Gallei, Alice Mundt, Veljko Nikolin
  • INTRANASAL VECTOR VACCINE AGAINST PORCINE EPIDEMIC DIARRHEA
    Publication number: 20200093918
    Abstract: The present invention relates to the field of (vector) vaccines, and especially to a canine distemper virus (CDV) vector comprising a heterologous nucleotide sequence which encodes a porcine epidemic diarrhea virus (PEDV) antigen. Said PEDV antigen is preferably a PEDV spike (S) protein. The viral vector of the present invention is useful for producing an immunogenic composition or vaccine for intranasally immunizing sows, and thereby protecting piglets, suckled by said sows, against the clinical signs associated with a PEDV infection.
    Type: Application
    Filed: September 18, 2019
    Publication date: March 26, 2020
    Inventors: Veljko NIKOLIN, Andreas GALLEI
  • MODIFIED PEDV SPIKE PROTEIN
    Publication number: 20200093919
    Abstract: The present invention relates to a modified porcine epidemic diarrhea virus (PEDV) spike (S) protein. Further, the present invention relates to immunogenic compositions comprising said modified PEDV spike protein and methods for immunizing a subject comprising the administration of said immunogenic composition to a subject.
    Type: Application
    Filed: September 18, 2019
    Publication date: March 26, 2020
    Inventors: Veljko NIKOLIN, Andreas GALLEI
  • NEW SWINE INFLUENZA VACCINE
    Publication number: 20180080044
    Abstract: The present invention relates to Equine Herpes Virus (EHV) vectors comprising at least one exogenous antigen encoding sequence relating to a pathogen infecting food producing animals, wherein said exogenous antigen encoding sequence is inserted into an insertion site, preferably ORF70, and said exogenous antigen encoding sequence is operably linked to a promoter sequence, preferably the promoter sequence comprising 4pgG600 (SEQ ID NO:1) or 4pMCP600 (SEQ ID NO:2) or the complementary nucleotide sequences thereof or a functional fragment or a functional derivative thereof or the complementary nucleotide sequences thereof. Furthermore, the present invention relates to methods for immunizing a food producing animal comprising administering to such food producing animal an immunogenic composition comprising embodiments of the present invention. Moreover, the present invention relates to methods for the treatment or prophylaxis of clinical signs caused by swine influenza virus in a food producing animal.
    Type: Application
    Filed: September 18, 2017
    Publication date: March 22, 2018
    Inventors: Andreas GALLEI, Alice MUNDT, Veljko NIKOLIN
  • Schmallenberg virus (SBV) vaccine, methods of production, and uses thereof
    Patent number: 9872897
    Abstract: The present invention relates to the field of vaccines and medicaments for the prophylaxis and treatment of infectious diseases in ruminants. In particular, it relates to inactivated Schmallenberg virus (SBV) useful as vaccine or medicament for preventing or treating viremia, the transmission and clinical symptoms, in particular malformations in newborn ruminants such as cattle, sheep and goats, induced by SBV.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: January 23, 2018
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Veljko Nikolin, Konrad Stadler, Axel Lischewski, Alexander Brix, Jeffrey P. Knittel, Katharina Hedwig Toepfer
  • SCHMALLENBERG VIRUS (SBV) VACCINE, METHODS OF PRODUCTION, AND USES THEREOF
    Publication number: 20160250317
    Abstract: The present invention relates to the field of vaccines and medicaments for the prophylaxis and treatment of infectious diseases in ruminants. In particular, it relates to inactivated Schmallenberg virus (SBV) useful as vaccine or medicament for preventing or treating viremia, the transmission and clinical symptoms, in particular malformations in newborn ruminants such as cattle, sheep and goats, induced by SBV.
    Type: Application
    Filed: May 19, 2016
    Publication date: September 1, 2016
    Inventors: Veljko NIKOLIN, Konrad STADLER, Axel LISCHEWSKI, Alexander BRIX, Jeffrey P. KNITTEL, Katharina Hedwig TOEPFER
  • Schmallenberg virus (SBV) vaccine, methods of production, and uses thereof
    Patent number: 9370562
    Abstract: The present invention relates to the field of vaccines and medicaments for the prophylaxis and treatment of infectious diseases in ruminants. In particular, it relates to inactivated Schmallenberg virus (SBV) useful as vaccine or medicament for preventing or treating viremia, the transmission and clinical symptoms, in particular malformations in newborn ruminants such as cattle, sheep and goats, induced by SBV.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: June 21, 2016
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Veljko Nikolin, Konrad Stadler, Axel Lischewski, Alexander Brix, Jeffrey P. Knittel, Katharina Hedwig Toepfer
  • SCHMALLENBERG VIRUS (SBV) VACCINE, METHODS OF PRODUCTION, AND USES THEREOF
    Publication number: 20130323277
    Abstract: The present invention relates to the field of vaccines and medicaments for the prophylaxis and treatment of infectious diseases in ruminants. In particular, it relates to inactivated Schmallenberg virus (SBV) useful as vaccine or medicament for preventing or treating viremia, the transmission and clinical symptoms, in particular malformations in newborn ruminants such as cattle, sheep and goats, induced by SBV.
    Type: Application
    Filed: May 29, 2013
    Publication date: December 5, 2013
    Applicant: BOEHRINGER INGELHEIM VETMEDICA GMBH
    Inventors: Veljko NIKOLIN, Konrad STADLER, Axel LISCHEWSKI, Alexander BRIX, Jeffrey P. KNITTEL, Katharina Hedwig TOEPFER