Patents by Inventor Vellimedu Kannappa Srinivas

Vellimedu Kannappa Srinivas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant streptokinase
    Patent number: 7105327
    Abstract: The present invention is based on the isolation of a gene coding for streptokinase from Streptococcus equisimilis (ATCC 9542), its cloning, and expression in E. coli. Two different strategies were carried out for the production of enzymatically-active streptokinase. In the first strategy, streptokinase was expressed as an inclusion body without its signal sequence followed by purification, solubulization, and renaturation to obtain an active preparation. The purified enzyme was formulated and lyophilized. In the second strategy, enzymatically-active streptokinase is secreted into the culture medium. The enzyme was purified, formulated and lyophilized.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: September 12, 2006
    Assignee: Bharat Biotech International, Ltd.
    Inventors: Mosuvan Kuppusamy, Vellimedu Kannappa Srinivas, Subhra Lahiri, Krishna Ella, Ghan Shyam Khatri