Abstract: Microporous membrane composites that are non-dewetting are disclosed. These microporous membrane composites are wet with solutions of methanol and water and are non-dewetting following autoclave treatment in water. The microporous membrane composites comprise a microporous membrane support that is coated with a crosslinked ionomer comprising hydrophilic groups. Compared to the microporous membrane support, the microporous membrane composite has a flow loss on average in isopropyl alcohol of less than 82%.

Abstract: Microporous membrane composites that are non-dewetting are disclosed. These microporous membrane composites are wet with solutions of methanol and water and are non-dewetting following autoclave treatment in water. The microporous membrane composites comprise a microporous membrane support that is coated with a crosslinked ionomer comprising hydrophilic groups. Compared to the microporous membrane support, the microporous membrane composite has a flow loss on average in isopropyl alcohol of less than 82%.

Abstract: Microporous membrane composites that are non-dewetting are disclosed. These microporous membrane composites are wet with solutions of methanol and water and are non-dewetting following autoclave treatment in water. The microporous membrane composites comprise a microporous membrane support that is coated with a crosslinked ionomer comprising hydrophilic groups. Compared to the microporous membrane support, the microporous membrane composite has a flow loss on average in isopropyl alcohol of less than 82%.

Abstract: Microporous membrane composites that are non-dewetting are disclosed. These microporous membrane composites are wet with solutions of methanol and water and are non-dewetting following autoclave treatment in water. The microporous membrane composites comprise a microporous membrane support that is coated with a crosslinked ionomer comprising hydrophilic groups. Compared to the microporous membrane support, the microporous membrane composite has a flow loss on average in isopropyl alcohol of less than 82%.

Abstract: Articles that include two or more exchange resins in one or more microporous membranes, where the membranes remove oppositely charged impurities from a fluid in contact with the membranes, are disclosed. Methods for using such devices to remove charged impurities from fluid in contact with the membrane are provided.

Abstract: A deep gradient-density filter device capable of effectively filtering a fluid containing a distribution of particles in the range of approximately 25 microns to approximately 0.2 micron at a fluid velocity of at least approximately 100 cm/hr and an initial hydraulic permeability of greater than approximately 10 cm/hr/psi. The deep gradient-density filter device includes several layers of filtration material, each having specific predetermined particle retention properties. In one product embodiment, the deep gradient-density filter device uses “loose” fibrillated cellulose fiber material as a primary filter element. In a method aspect, the deep gradient-density filter device is used for either the secondary clarification of industrial-scale volumes of cultured or fermented protein-containing biopharmaceutical fluids or the primary clarification of pilot-scale volumes.

Abstract: The present invention provides a deep gradient-density filter device capable of effectively filtering a fluid containing a distribution of particles in the range of approximately 25 microns to approximately 0.2 micron at a fluid velocity of at least approximately 100 cm/hr and an initial hydraulic permeability of greater than approximately 10 cm/hr/psi. The deep gradient-density filter device comprises several layers of filtration material, each having specific predetermined particle retention properties. In one product embodiment of the present invention, the deep gradient-density filter device uses “loose” fibrillated cellulose fiber material as a primary filter element. In a method aspect of the invention, the deep gradient-density filter device is used for either the secondary clarification of industrial-scale cultured or fermented protein-containing biopharmaceutical fluids or the primary clarification of pilot-scale volumes of said fluids.

Abstract: An electrodeionization (EDI) module is formed from an anode spaced apart from a cathode, one or more waste channels formed between the electrodes and a product channel located inward of the waste channel(s). Ion permeable membranes form the boundary between the product channel and the waste channel(s). The product channel and waste channels are filled with a mixture of anionic and cationic ion exchange materials. At least the waste channel(s) and preferably the product channel as well, use either an anion bead having a relatively low affinity for the selected anion specie(s) to be retained (e.g. Type II) or it is a blend with Type I materials. Preferably, the membranes contain an ion exchange material to speed the transfer of ions across them. More preferably, the anionic membrane contains anion materials that have a relatively low affinity for the selected specie or species for retention.

Abstract: An electrodeionization (EDI) module is formed an anode spaced apart from a cathode, one or more waste channels formed between the electrodes and a product channel located inward of the waste channel(s). Ion permeable membranes form the boundary between the product channel and the waste channel(s). The product channel and waste channels are filled with a mixture of anionic and cationic ion exchange materials. At least the waste channel(s) and preferably the product channel as well, use either an anion bead having a relatively low affinity for the selected anion specie(s) to be retained (e.g. Type II) or it is a blend with Type I materials. Preferably, the membranes contain an ion exchange material to speed the transfer of ions across them. More preferably, the anionic membrane contains anion materials that have a relatively low affinity for the selected specie or species for retention.