Patents by Inventor Venera Bouriakov

Venera Bouriakov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System and method for targeted depletion of nucleic acids
    Patent number: 11155853
    Abstract: The present disclosure provides a system and method for depleting target nucleic acids from a nucleic acid sample. In one aspect, a kit according to the present disclosure includes a plurality of DNA probes. Each of the DNA probes is hybridizable to form a heteroduplex with at least one of a plurality of target RNA transcripts in a nucleic acid sample. The number of unique target RNA transcripts hybridized by the plurality of DNA probes is at least three. The kit further includes an enzyme having RNA-DNA hybrid ribonucleotidohydrolase activity, where degrades at least the RNA portion of the heteroduplex.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: October 26, 2021
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Venera Bouriakov, Daniel Burgess
  • SYSTEM AND METHOD FOR TARGETED DEPLETION OF NUCLEIC ACIDS
    Publication number: 20200024646
    Abstract: The present disclosure provides a system and method for depleting target nucleic acids from a nucleic acid sample. In one aspect, a kit according to the present disclosure includes a plurality of DNA probes. Each of the DNA probes is hybridizable to form a heteroduplex with at least one of a plurality of target RNA transcripts in a nucleic acid sample. The number of unique target RNA transcripts hybridized by the plurality of DNA probes is at least three. The kit further includes an enzyme having RNA-DNA hybrid ribonucleotidohydrolase activity, where degrades at least the RNA portion of the heteroduplex.
    Type: Application
    Filed: October 3, 2019
    Publication date: January 23, 2020
    Inventors: Venera Bouriakov, Daniel Burgess
  • System and method for targeted depletion of nucleic acids
    Patent number: 10472666
    Abstract: The present disclosure provides a system and method for depleting target nucleic acids from a nucleic acid sample. In one aspect, a kit according to the present disclosure includes a plurality of DNA probes. Each of the DNA probes is hybridizable to form a heteroduplex with at least one of a plurality of target RNA transcripts in a nucleic acid sample. The number of unique target RNA transcripts hybridized by the plurality of DNA probes is at least three. The kit further includes an enzyme having RNA-DNA hybrid ribonucleotidohydrolase activity, where degrades at least the RNA portion of the heteroduplex.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: November 12, 2019
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Venera Bouriakov, Daniel Burgess
  • System and Method for Targeted Depletion of Nucleic Acids
    Publication number: 20190284602
    Abstract: The present disclosure provides a system and method for depleting target nucleic acids from a nucleic acid sample. In one aspect, a kit according to the present disclosure includes a plurality of DNA probes. Each of the DNA probes is hybridizable to form a heteroduplex with at least one of a plurality of target RNA transcripts in a nucleic acid sample. The number of unique target RNA transcripts hybridized by the plurality of DNA probes is at least three. The kit further includes an enzyme having RNA-DNA hybrid ribonucleotidohydrolase activity, where degrades at least the RNA portion of the heteroduplex.
    Type: Application
    Filed: February 3, 2017
    Publication date: September 19, 2019
    Inventors: Venera Bouriakov, Daniel Burgess
  • System and Method for Targeted Depletion of Nucleic Acids
    Publication number: 20180223331
    Abstract: The present disclosure provides a system and method for depleting target nucleic acids from a nucleic acid sample. In one aspect, a kit according to the present disclosure includes a plurality of DNA probes. Each of the DNA probes is hybridizable to form a heteroduplex with at least one of a plurality of target RNA transcripts in a nucleic acid sample. The number of unique target RNA transcripts hybridized by the plurality of DNA probes is at least three. The kit further includes an enzyme having RNA-DNA hybrid ribonucleotidohydrolase activity, where degrades at least the RNA portion of the heteroduplex.
    Type: Application
    Filed: February 3, 2017
    Publication date: August 9, 2018
    Inventors: Venera Bouriakov, Daniel Burgess