Patents by Inventor Venkata Lakshmi Narasimha Rao Dammalapati

Venkata Lakshmi Narasimha Rao Dammalapati has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of 3?-deoxyadenosine-5?-O-[phenyl(benzyloxy-L-alaninyl)]phosphate (NUC-738)
    Patent number: 11897913
    Abstract: The present invention generally relates to a novel process for the preparation of 3?-deoxyadenosine derivatives, and particularly NUC-7738 (3?-deoxyadenosine-5?-O-[phenyl(benzyloxy-L-alaninyl)] phosphate) an anticancer ProTide of deoxyadenosine.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: February 13, 2024
    Assignee: NuCana plc
    Inventors: Venkata Lakshmi Narasimha Rao Dammalapati, Mani Bushan Kotala
  • Diastereoselective synthesis of phosphate derivatives
    Patent number: 11603382
    Abstract: The present invention provides a method for the preparation of intermediates useful in the synthesis of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate. It also provides a method of preparing gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: March 14, 2023
    Assignee: NuCana plc
    Inventors: Mani Bushan Kotala, Venkata Lakshmi Narasimha Rao Dammalapati
  • Process for the preparation of ivacaftor and its intermediates
    Patent number: 11414386
    Abstract: The present invention provides processes for the preparation of ivacaftor using novel intermediates and a process for its preparation.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: August 16, 2022
    Assignee: Laurus Labs Limited
    Inventors: Suresh Thatipally, Venkata Krishna Reddy, Venkata Lakshmi Narasimha Rao Dammalapati, Satyanarayana Chava
  • Synthesis of phosphate derivatives
    Patent number: 11414452
    Abstract: The present invention is a process for the preparation of certain 5?-phosphoramidate nucleotide diastereoisomers. The phosphoramidates include those useful in the treatment of cancer such as NUC-3373 (5-fluoro-2?-deoxyuridine-5?-O-[1-naphthyl(benzyloxy-L-alaninyl)]phosphate).
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: August 16, 2022
    Assignee: NuCana plc
    Inventors: Hugh Griffith, Gordon Kennovin, Venkata Lakshmi Narasimha Rao Dammalapati, Mani Bushan Kotala
  • Floxuridine synthesis
    Patent number: 11414451
    Abstract: The present invention relates to a process for the preparation of floxuridine. Floxuridine may be useful as an anti-cancer drug. Floxuridine may also be useful in the preparation of other anti-cancer drugs, e.g. NUC-3373.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: August 16, 2022
    Assignee: NuCana plc
    Inventors: Mani Bushan Kotala, Venkata Lakshmi Narasimha Rao Dammalapati
  • CRYSTALLINE FORM OF NILOTINIB HYDROCHLORIDE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
    Publication number: 20210380557
    Abstract: The present invention relates to novel crystalline form of nilotinib hydrochloride, process for its preparation and pharmaceutical composition comprising the same.
    Type: Application
    Filed: November 5, 2019
    Publication date: December 9, 2021
    Inventors: Ram Thaimattam, Suresh Babu Radhakrishnan, Nageswara Rao Regandla, Venkata Lakshmi Narasimha Rao Dammalapati, Uma Maheswer Rao Vasireddi
  • DIASTEREOSELECTIVE SYNTHESIS OF PHOSPHATE DERIVATIVES
    Publication number: 20210009625
    Abstract: The present invention provides a method for the preparation of intermediates useful in the synthesis of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate. It also provides a method of preparing gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate.
    Type: Application
    Filed: August 12, 2020
    Publication date: January 14, 2021
    Inventors: Mani Bushan Kotala, Venkata Lakshmi Narasimha Rao Dammalapati
  • PROCESS FOR THE PREPARATION OF IVACAFTOR AND ITS ITERMEDIATES
    Publication number: 20200407323
    Abstract: The present invention provides processes for the preparation of ivacaftor using novel intermediates and a process for its preparation.
    Type: Application
    Filed: September 16, 2020
    Publication date: December 31, 2020
    Applicant: Laurus Labs Limited
    Inventors: Suresh Thatipally, Venkata Krishna Reddy, Venkata Lakshmi Narasimha Rao Dammalapati, Satyanarayana Chava
  • Process for the preparation of ivacaftor
    Patent number: 10815202
    Abstract: The present invention provides processes for the preparation of ivacaftor using novel intermediates and a process for its preparation.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: October 27, 2020
    Assignee: Laurus Labs Limited
    Inventors: Suresh Thatipally, Venkata Krishna Reddy, Venkata Lakshmi Narasimha Rao Dammalapati, Satyanarayana Chava
  • Diastereoselective synthesis of phosphate derivatives
    Patent number: 10774104
    Abstract: Disclosed is a method for the preparation of intermediates useful in the synthesis of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate. Also disclosed is a method of preparing gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: September 15, 2020
    Assignee: Laurus Labs Private Ltd
    Inventors: Mani Bushan Kotala, Venkata Lakshmi Narasimha Rao Dammalapati
  • SYNTHESIS OF PHOSPHATE DERIVATIVES
    Publication number: 20200181186
    Abstract: The present invention generally relates to a process for the preparation of certain anticancer compounds as specific phosphate diastereoisomers.
    Type: Application
    Filed: June 14, 2018
    Publication date: June 11, 2020
    Inventors: Hugh Griffith, Gordon Kennovin, Venkata Lakshmi Narasimha Rao Dammalapati, Mani Bushan Kotala
  • SYNTHESIS OF 3'-DEOXYADENOSINE-5'-O-[PHENYL(BENZYLOXY-L-ALANINYL)]PHOSPHATE (NUC-7738)
    Publication number: 20200181190
    Abstract: The present invention generally relates to a novel process for the preparation of 3?-deoxyadenosine derivatives, and particularly NUC-7738 (3?-deoxyadenosine-5?-O-[phenyl(benzyloxy-L-alaninyl)] phosphate) an anticancer ProTide of deoxyadenosine.
    Type: Application
    Filed: June 14, 2018
    Publication date: June 11, 2020
    Inventors: Venkata Lakshmi Narasimha Rao Dammalapati, Mani Bushan Kotala
  • Processes for the preparation of ivacaftor
    Patent number: 10501419
    Abstract: The present invention provides processes for the preparation of ivacaftor using novel intermediates and a process for its preparation.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: December 10, 2019
    Assignee: Laurus Labs Limited
    Inventors: Suresh Thatipally, Venkata Krishna Reddy, Venkata Lakshmi Narasimha Rao Dammalapati, Satyanarayana Chava
  • PROCESS FOR THE PREPARATION OF IVACAFTOR
    Publication number: 20190345111
    Abstract: The present invention provides processes for the preparation of ivacaftor using novel intermediates and a process for its preparation.
    Type: Application
    Filed: July 24, 2019
    Publication date: November 14, 2019
    Applicant: Laurus Labs Ltd.
    Inventors: SURESH THATIPALLY, Venkata Krishna Reddy, Venkata Lakshmi Narasimha Rao Dammalapati, Satyanarayana Chava
  • PROCESSES FOR THE PREPARATION OF IVACAFTOR
    Publication number: 20180244622
    Abstract: The present invention provides processes for the preparation of ivacaftor using novel intermediates and a process for its preparation.
    Type: Application
    Filed: September 2, 2016
    Publication date: August 30, 2018
    Applicant: Laurus Labs Ltd.
    Inventors: Suresh Thatipally, Venkata Krishna Reddy, Venkata Lakshmi Narasimha Rao Dammalapati, Satyanarayana Chava
  • Process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate
    Patent number: 9834577
    Abstract: The present invention provides a process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate of Formula I in high yield and purity.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: December 5, 2017
    Assignee: Laurus Labs Limited
    Inventors: Venkata Lakshmi Narasimha Rao Dammalapati, Mani Bushan Kotala, Shankar Madhavaram
  • PROCESS FOR THE PREPARATION OF GEMCITABINE-[PHENYL(BENZOXY-L-ALANINYL)] PHOSPHATE
    Publication number: 20170166602
    Abstract: The present invention provides a process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate of Formula I in high yield and purity.
    Type: Application
    Filed: July 22, 2015
    Publication date: June 15, 2017
    Applicants: NuCana Biomed Limited, Laurus Labs Private Ltd.
    Inventors: Venkata Lakshmi Narasimha Rao Dammalapati, Mani Bushan Kotala, Shankar Madhavaram
  • Process for the preparation of Ivacaftor and its intermediates
    Patent number: 9573902
    Abstract: The present invention provides novel intermediates of ivacaftor and process for its preparation. The present invention also provides process for the preparation of ivacaftor and pharmaceutically acceptable salt thereof using novel intermediates.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: February 21, 2017
    Assignee: LAURUS LABS PRIVATE LTD.
    Inventors: Suresh Thatipally, Venkata Lakshmi Narasimha Rao Dammalapati, Seeta Ramanjaneyulu Gorantla, Satyanarayana Chava
  • PROCESS FOR THE PREPARATION OF IVACAFTOR AND ITS INTERMEDIATES
    Publication number: 20160016909
    Abstract: The present invention provides novel intermediates of ivacaftor and process for its preparation. The present invention also provides process for the preparation of ivacaftor and pharmaceutically acceptable salt thereof using novel intermediates.
    Type: Application
    Filed: February 14, 2014
    Publication date: January 21, 2016
    Inventors: Suresh THATIPALLY, Venkata Lakshmi Narasimha Rao DAMMALAPATI, Seeta Ramanjaneyulu GORANTLA, Satyanarayana CHAVA
  • PROCESS FOR THE PREPARATION OF VILANTEROL AND INTERMEDIATES THEREOF
    Publication number: 20150239862
    Abstract: An improved process for the preparation of vilanterol and pharmaceutically acceptable salts thereof is disclosed. More specifically the improved process for preparing intermediates for the preparation of vilanterol is disclosed.
    Type: Application
    Filed: September 13, 2013
    Publication date: August 27, 2015
    Inventors: Venkata Lakshmi Narasimha Rao Dammalapati, Hari Krishna Mudduluru, Ravindra Aduri