Abstract: The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

Abstract: The present invention is directed to a film or coating comprising a fiber material, wherein at least 60% by weight of said fiber material is microfibrillated cellulose, said film or coating also comprising at least 1% by weight of extractives from wood bark or cork wood. The invention is also directed to products, such as packaging materials, using or incorporating said film or coating. Such packaging materials are for example laminates or multi-layer structures. The films or coatings according to the present invention having advantageous barrier properties and are therefore particularly suitable for sensitive objects that need to be packaged in a controlled or modified atmosphere. The present invention is also directed to a composition comprising a fiber material, wherein at least 60% by weight of said fiber material is microfibrillated cellulose, said composition also comprising at least 1% by weight of extractives from wood bark or cork wood.

Abstract: A method and system for managing Wireless Avionics Intra-Communication Systems (WAICSs) in a Radio Altimeter (RA) band is disclosed. The method includes allocating, by a communication management device, a plurality of RA sub-bands within the RA band to a plurality of WAICS transmitters, wherein each of the plurality of WAICS transmitters is allocated at least one of the plurality of RA sub-bands; detecting, by the communication management device, overlap of an RA signal with at least one RA sub-band from the plurality of RA sub-bands; and switching off, iteratively by the communication management device, at least one of the plurality of WAICS transmitters whose allocated RA-sub-band overlaps with at least a part of the RA signal.

Abstract: A technique is provided for localizing a plurality of wireless transmitters. The technique includes retrieving Received Signal Strength Indicator (RSSI) values measured by one or more sensors, corresponding to the plurality of wireless transmitters distributed in a region in which the sensors are located. The technique further comprises generating, a plurality of clusters based on the retrieved RSSI values. The technique further comprises generating a binary image based on the generated clusters. The binary image comprises one or more white regions and one or more black regions. The technique further comprises localizing position of each of the plurality of wireless transmitters, based on a determination of contours of the one or more white regions present in the binary image.

Abstract: A method and system for managing Wireless Avionics Intra-Communication Systems (WAICSs) in a Radio Altimeter (RA) band is disclosed. The method includes allocating, by a communication management device, a plurality of RA sub-bands within the RA band to a plurality of WAICS transmitters, wherein each of the plurality of WAICS transmitters is allocated at least one of the plurality of RA sub-bands; detecting, by the communication management device, overlap of an RA signal with at least one RA sub-band from the plurality of RA sub-bands; and switching off, iteratively by the communication management device, at least one of the plurality of WAICS transmitters whose allocated RA-sub-band overlaps with at least a part of the RA signal.

Abstract: A technique is provided for controlling a transmit range of a wireless transmitter. The technique includes retrieving Received Signal Strength Indicator (RSSI) values measured by one or more sensors, corresponding to the plurality of wireless transmitters distributed in a region in which the sensors are located. A plurality of parameters associated with the wireless transmitter to be placed within the region are received. The plurality of parameters includes a minimum range of transmission of the wireless transmitter and a preferred position in the region. A plurality of clusters are generated based on the retrieved RSSI values and the minimum range. Further, one or more positions for placing the wireless transmitter within a cluster from the plurality of clusters, and a maximum range of transmission at each of the one or more positions, are determined. The maximum range is determined by controlling a range of transmission of the wireless transmitter.

Abstract: A technique is provided for localizing a plurality of wireless transmitters. The technique includes retrieving Received Signal Strength Indicator (RSSI) values measured by one or more sensors, corresponding to the plurality of wireless transmitters distributed in a region in which the sensors are located. The technique further comprises generating, a plurality of clusters based on the retrieved RSSI values. The technique further comprises generating a binary image based on the generated clusters. The binary image comprises one or more white regions and one or more black regions. The technique further comprises localizing position of each of the plurality of wireless transmitters, based on a determination of contours of the one or more white regions present in the binary image.

Abstract: A passenger control unit is provided that may include a push-button, power assembly, and control and communication circuitry. The push-button may be for control of a passenger service unit (PSU) onboard a passenger vehicle, and may also generate mechanical energy when pushed. The power assembly may convert the mechanical energy to electrical energy, and store the electrical energy, solely from which the control and communication circuitry may be powered. The control and communication circuitry may include a microprocessor and a communications interface. The microprocessor may receive an indication when the push-button is pushed, and generate an instruction to control the PSU in response thereto. And the communications interface wirelessly transmit the instruction to a control unit configured to effect control of the PSU based thereon.

Abstract: The present invention relates to a method of enzymatic hydrolysis of a lignocellulosic material, comprising the steps of: a) pretreating the lignocellulosic material to obtain a slurry having a pH of less than 6; b) adding NaOH, Ca(OH)2 and/or CaO to the slurry to increase its pH to at least 8, said addition being carried out at a slurry temperature of at least 60° C.; c) reducing the pH of the slurry to below 7; and optionally cooling the slurry from step b) to a temperature below 60° C.; and d) adding hydrolytic enzymes to the slurry from c) and allowing the slurry to hydrolyze wherein no washing of the slurry is performed prior to step d).

Abstract: A passenger control unit is provided that may include a push-button, power assembly, and control and communication circuitry. The push-button may be for control of a passenger service unit (PSU) onboard a passenger vehicle, and may also generate mechanical energy when pushed. The power assembly may convert the mechanical energy to electrical energy, and store the electrical energy, solely from which the control and communication circuitry may be powered. The control and communication circuitry may include a microprocessor and a communications interface. The microprocessor may receive an indication when the push-button is pushed, and generate an instruction to control the PSU in response thereto. And the communications interface wirelessly transmit the instruction to a control unit configured to effect control of the PSU based thereon.

Abstract: A method is provided for improving enzymatic hydrolysis in saccharification of a lignocellulosic material. The method is comprising pretreating the lignocellulosic material to obtain a slurry of pretreated lignocellulosic material; adding at least one reducing agent to the slurry of pretreated lignocellulosic material or the liquid fraction thereof to decrease the enzymatic hydrolysis inhibitory properties of slurry of the pretreated lignocellulosic material or the liquid fraction thereof; and subjecting the slurry of pretreated lignocellulosic material or the liquid fraction thereof to enzymatic hydrolysis in the presence of the at least one reducing agent.

Abstract: The present invention relates to a method of enzymatic hydrolysis of a lignocellulosic material, comprising the steps of: a) pretreating the lignocellulosic material to obtain a slurry having a pH of less than 6; b) adding NaOH, Ca(OH)2 and/or CaO to the slurry to increase its pH to at least 8, said addition being carried out at a slurry temperature of at least 60° C.; c) reducing the pH of the slurry to below 7; and optionally cooling the slurry from step b) to a temperature below 60° C.

Abstract: A method is provided for improving enzymatic hydrolysis in saccharification of a lignocellulosic material. The method is comprising pretreating the lignocellulosic material to obtain a slurry of pretreated lignocellulosic material; adding at least one reducing agent to the slurry of pretreated lignocellulosic material or the liquid fraction thereof to decrease the enzymatic hydrolysis inhibitory properties of slurry of the pretreated lignocellulosic material or the liquid fraction thereof; and subjecting the slurry of pretreated lignocellulosic material or the liquid fraction thereof to enzymatic hydrolysis in the presence of the at least one reducing agent.