Abstract: In an approach to reduce nitrous oxide emissions using predictive urea dosing control, a route is determined. A set of target coverage fractions of ammonia is determined over a set of steps for the route, where the coverage fraction of ammonia is a ratio of stored ammonia to a maximum storage capacity of ammonia in a selective catalytic reduction (SCR) device. An actual coverage fraction of ammonia is determined for each step of the route. The actual coverage fraction of ammonia is compared to the target coverage fraction of ammonia for each step. The urea injection rate is adjusted based on a cost function.