Patents by Inventor Venkatachalam ANGAMUTHU

Venkatachalam ANGAMUTHU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing optically active antrocin
    Patent number: 8658806
    Abstract: The present invention relates to a process of preparation of optically active antrocin. At first, to introduce the correct configuration of trans-decalone, alkyl aluminum/TMSCN was used to react with decalenone. The resulting racemic nitrile-decalone was resolved with chiral diol by ketalization to produce two chromatography separable diasteromers. After a simple column chromatography, optically pure compounds were obtained. Formylation was a critical step for the lactone formation. The rest of the synthesis is straight forward through oxidation and olefination. Accordingly, the total synthesis was completed in 10 steps with 7% overall yield from commercially available 6-methoxy-2-tetralone.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: February 25, 2014
    Assignee: Deyew Biotech Corp.
    Inventors: Dar-Fu Tai, Venkatachalam Angamuthu, Yew-Min Tzeng
  • PROCESS FOR PREPARING OPTICALLY ACTIVE ANTROCIN
    Publication number: 20130096324
    Abstract: The present invention relates to a process of preparation of optically active antrocin. At first, to introduce the correct configuration of trans-decalone, alkyl aluminum/TMSCN was used to react with decalenone. The resulting racemic nitrile-decalone was resolved with chiral diol by ketalization to produce two chromatography separable diasteromers. After a simple column chromatography, optically pure compounds were obtained. Formylation was a critical step for the lactone formation. The rest of the synthesis is straight forward through oxidation and olefination. Accordingly, the total synthesis was completed in 10 steps with 7% overall yield from commercially available 6-methoxy-2-tetralone.
    Type: Application
    Filed: September 14, 2012
    Publication date: April 18, 2013
    Applicant: DEYEW BIOTECH CORP.
    Inventors: Dar-fu TAI, Venkatachalam ANGAMUTHU, Yew-min TZENG