Patents by Inventor Venkataraman Amarnath

Venkataraman Amarnath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR SCAVENGING DICARBONYL ELECTROPHILES
    Publication number: 20240000726
    Abstract: Compounds and methods of scavenging bifunctional electrophiles and reducing the occurrence of lysyl-levuglandin adducts in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein.
    Type: Application
    Filed: July 10, 2023
    Publication date: January 4, 2024
    Inventors: Keith T. Wilson, John A. Oates, Olivier Boutaud, Venkataraman Amarnath, Erica J. Carrier, Alain P. Gobert
  • Compounds and methods for scavenging dicarbonyl electrophiles
    Patent number: 11696903
    Abstract: Compounds and methods of scavenging bifunctional electrophiles and reducing the occurrence of lysyl-levuglandin adducts in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: July 11, 2023
    Assignees: Vanderbilt University, The United States as Represented by the Department of Veterans Affairs
    Inventors: Keith T. Wilson, John A. Oates, Olivier Boutaud, Venkataraman Amarnath, Erica J. Carrier, Alain P. Gobert
  • MITOCHONDRIA-TARGETED ISOKETAL/ISOLEVUGLANDIN SCAVENGERS AND USES THEREOF
    Publication number: 20230098649
    Abstract: The use of novel 2-hydroxybenzylamine derivatives as scavengers of isolevuglandins.
    Type: Application
    Filed: January 27, 2021
    Publication date: March 30, 2023
    Inventors: Sergey I Dikalov, Venkataraman Amarnath
  • Methods for treating atherosclerosis with gamma-ketoaldehyde scavengers
    Patent number: 11389414
    Abstract: A method of treating atherosclerosis, comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: July 19, 2022
    Assignee: Vanderbilt University
    Inventors: Macrae F. Linton, John A. Oates, Sean S. Davies, L. Jackson Roberts, II, Venkataraman Amarnath, Patricia G. Yancey, Huan Tao
  • MITOCHONDRIA-TARGETED ISOKETAL/ISOLEVUGLANDIN SCAVENGERS
    Publication number: 20220162240
    Abstract: Compounds and methods for treating, preventing, and ameliorating at least one of vascular oxidative stress, improve vascular functions and/or reduce hypertension, comprising administering to a subject a compound that targets mitochondrial CypD to inhibit vascular oxidative stress, improve vascular functions and/or reduce hypertension.
    Type: Application
    Filed: January 27, 2020
    Publication date: May 26, 2022
    Inventors: Sergey I Dikalov, Venkataraman Amarnath
  • METHODS FOR TREATING INFLAMMATION AND HYPERTENSION WITH GAMMA-KETOALDEHYDE SKAVENGERS
    Publication number: 20210261508
    Abstract: A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Application
    Filed: April 13, 2021
    Publication date: August 26, 2021
    Inventors: L. Jackson Roberts, II, Venkataraman Amarnath, David G. Harrison, Annet Kirabo
  • Methods for treating inflammation and hypertension with ?-ketoaldehyde skavengers
    Patent number: 10975033
    Abstract: A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: April 13, 2021
    Assignee: Vanderbilt University
    Inventors: L. Jackson Roberts, II, Venkataraman Amarnath, David G. Harrison, Annet Kirabo
  • COMPOUNDS AND METHODS FOR SCAVENGING DICARBONYL ELECTROPHILES
    Publication number: 20200383938
    Abstract: Compounds and methods of scavenging bifunctional electrophiles and reducing the occurrence of lysyl-levuglandin adducts in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein.
    Type: Application
    Filed: June 4, 2020
    Publication date: December 10, 2020
    Inventors: Keith T. Wilson, John A. Oates, Olivier Boutaud, Venkataraman Amarnath, Erica J. Carrier, Alain P. Gobert
  • METHODS FOR TREATING ATHEROSCLEROSIS WITH GAMMA-KETOALDEHYDE SCAVENGERS
    Publication number: 20200138747
    Abstract: A method of treating atherosclerosis, comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Application
    Filed: April 27, 2018
    Publication date: May 7, 2020
    Inventors: MacRae F. Linton, John A. Oates, Sean S. Davies, L. Jackson Roberts, II, Venkataraman Amarnath, Patricia G. Yancey, Huan Tao
  • Prevention And Treatment Of Atrial Fibrillation/Flutter With Gamma-Ketoaldehyde Scavengers
    Publication number: 20190247375
    Abstract: Methods and compositions for use in treating atrial fibrillation in a subject. The compounds of the present invention are gamma-ketoaldehyde scavengers.
    Type: Application
    Filed: July 7, 2017
    Publication date: August 15, 2019
    Inventors: Katherine T. MURRAY, L. Jackson ROBERTS, II, Venkataraman AMARNATH
  • LEVUGLANDIN ADDUCTS HISTONE H4 IN A CYCLOOXYGENASE-2-DEPENDENT MANNER, ALTERING ITS INTERACTION WITH DNA
    Publication number: 20150265584
    Abstract: Method of inhibiting formation of levuglandin adducts of histone and DNA in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein.
    Type: Application
    Filed: March 18, 2015
    Publication date: September 24, 2015
    Inventors: John A. Oates, Olivier Boutaud, Venkataraman Amarnath, Erica J. Carrier
  • METHODS FOR TREATING INFLAMMATION AND HYPERTENSION WITH GAMMA-KETOALDEHYDE SKAVENGERS
    Publication number: 20140256774
    Abstract: A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Application
    Filed: July 12, 2012
    Publication date: September 11, 2014
    Applicant: VANDERBILT UNIVERSITY
    Inventors: L. Jackson Roberts, Venkataraman Amarnath, David G. Harrison
  • Isoketal scavengers and mitigation of disorders involving oxidative injury
    Patent number: 8822542
    Abstract: A method of treating and/or preventing oxidative damage, comprising administering an effective IsoK/NeuroK adduct formation suppressing amount of a phenolic amine compound and/or pyridoxamine or pyridoxamine analog, including embodiments where the phenolic compound is at least one of a pyridoxamine, salicylamine, tyrosine compound or an analog thereof.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: September 2, 2014
    Assignee: Vanderbilt University
    Inventors: L. Jackson Roberts, II, Jeffrey R. Balser, Sean S. Davies, Venkataraman Amarnath, Prakash C. Viswanathan
  • ISOKETAL SCAVENGERS AND MITIGATION OF DISORDERS INVOLVING OXIDATIVE INJURY
    Publication number: 20120157501
    Abstract: A method of treating and/or preventing oxidative damage, comprising administering an effective IsoK/NeuroK adduct formation suppressing amount of a phenolic amine compound and/or pyridoxamine or pyridoxamine analog, including embodiments where the phenolic compound is at least one of a pyridoxamine, salicylamine, tyrosine compound or an analog thereof.
    Type: Application
    Filed: February 27, 2009
    Publication date: June 21, 2012
    Inventors: L. Jackson Roberts, II, Jeffrey R. Balser, Sean S. Davies, Venkataraman Amarnath, Prakash C. Viswanathan
  • Method of preventing and/or treating oxidant injury in neurodegenerative and oxidative diseases
    Patent number: 7705054
    Abstract: A method of treating and/or preventing oxidative damage, comprising administering an effective IsoK/NeuroK adduct formation suppressing amount of a phenolic amine compound and/or pyridoxamine or pyridoxamine analog, including embodiments where the phenolic compound is at least one of a pyridoxamine, salicylamine, tyrosine compound or an analog thereof.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: April 27, 2010
    Assignee: Vanderbilt University
    Inventors: L. Jackson Roberts, II, Jeffrey R. Balser, Sean S. Davies, Prakash C. Viswanathan, Venkataraman Amarnath