Patents by Inventor Venkatesh Swaminathan

Venkatesh Swaminathan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators (inhibitors/activators) of histone acetyltransferases
    Patent number: 7750047
    Abstract: The invention provides the use of certain benzoic acid and benzamide compounds as modulators of enzymes histone acetyltransferases, which are involved in gene expression and cancer and also use of such compounds in the treatment of diseases due to defects in gene regulation predominantly cancer.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: July 6, 2010
    Assignee: Jawaharlal Nehru Centre for Advanced Scientific Research
    Inventors: Tapas Kumar Kundu, Karanam Balasubramanyam, Venkatesh Swaminathan
  • MODULATORS (INHIBITORS/ACTIVATORS) OF HISTONE ACETYLTRANSFERASES
    Publication number: 20090076155
    Abstract: The invention provides the use of certain benzoic acid and benzamide compounds as modulators of enzymes histone acetyltransferases, which are involved in gene expression and cancer and also use of such compounds in the treatment of diseases due to defects in gene regulation predominantly cancer.
    Type: Application
    Filed: December 19, 2007
    Publication date: March 19, 2009
    Inventors: Tapas Kumar Kundu, Karanam Balasubramanyam, Venkatesh Swaminathan
  • Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases and uses thereof
    Patent number: 7402706
    Abstract: In this patent we describe the purification of prenylated benzophenones from the fruit rinds of Garcinia species and its evaluation as an inhibitor for Histone acetyltransferases p300 and PCAF. We have found that prenylated benzophenones are potent HAT inhibitors of p300 (IC50-1 ?M) and pCAF (IC50-15 ?M). The inhibitors significantly repress the p300 HAT dependent transcriptional activation from in vitro assembled chromatin template but had no effect on transcription from DNA. These results suggest that the compounds could be specific to HATs. Thus these compounds should be useful as biological switching molecule for evaluating the role of p300 and PCAF in cellular functions and may be useful as new chemical entities for the development of anticancer drugs.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: July 22, 2008
    Assignee: Jawaharlal Nehru Centre for Advanced Scientific Research
    Inventors: Kundu Tapas Kumar, Karanam Balasubramanyam, Kempegowda Mantelingu, Altaf Mohammad, Venkatesh Swaminathan, A. Varier Radhika
  • Polyisoprenylated Benzophenones and Their Isomers as Inhibitors of Histone Acetyltransferases and Uses thereof
    Publication number: 20070254961
    Abstract: In this patent we describe the purification of prenylated benzophenones from the fruit rinds of Garcinia species and its evaluation as an inhibitor for Histone acetyltransferases p300 and PCAF. We have found that prenylated benzophenones are potent HAT inhibitors of p300 (IC50-1 ?M) and pCAF (IC50-15 ?M). The inhibitors significantly repress the p300 HAT dependent transcriptional activation from in vitro assembled chromatin template but had no effect on transcription from DNA. These results suggest that the compounds could be specific to HATs. Thus these compounds should be useful as biological switching molecule for evaluating the role of p300 and PCAF in cellular functions and may be useful as new chemical entities for the development of anticancer drugs.
    Type: Application
    Filed: November 4, 2004
    Publication date: November 1, 2007
    Applicant: JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH
    Inventors: Kundu Tapas Kumar, Karanam Balasubramanyam, Kempegowda Mantelingu, Altaf Mohammad, Venkatesh Swaminathan, A. Radhika