Abstract: A smart air-purifier system to provide improved air quality in a negative pressure enclosure is disclosed. The system comprises a machine housing that encloses a filter unit to remove airborne particles. The filter unit includes a high-efficiency particulate air (HEPA) filter. The system further includes one or more sensors to monitor the air quality and maintain the random forest approach (RAQ) for predicting air quality, a server to store a plurality of real-time data of the air-purifier system, and a user device to access the plurality of data stored in the server. Further, the real-time data is analyzed using internet-of-things (IoT) to perform surveillance to capture and monitor infection prevention and control data using a mobile application. The system further comprises a four-node controller inside the machine housing configured to switch on and off the system. Also, the system further comprises one or more ultraviolet (UV) lamps and an ionizer.