Abstract: The present disclosure provides methods and compositions useful for diagnosing and treating activated alternative pathway of complement in a human subject with a SARS-CoV-2 infection. Also provided are methods of treating an infection by a betacoronavirus, e.g., SARS-CoV, MERS-CoV, or SARS-CoV-2, in a human subject. The methods of treatment include administering to the human subject a therapeutically effective amount of at least one complement factor D inhibitor. Also provided herein are compounds for treating an infection by a betacoronavirus and their use in the manufacture in a medicament for treating an infection by a betacoronavirus.

Abstract: A system and method is provided for sourcing agreement and performance analysis comprising the steps of identifying scenarios for material requirements, identifying scenarios for supply environments, identifying terms of existing and/or prospective sourcing agreements, identifying a set of sourcing agreement utilization policies, identifying inventory-related and shortage costs scenarios, and computing future sourcing performance based on the identified scenarios, existing or prospective sourcing agreements, and sourcing agreement utilization policies. Various cost/risk and other future performance measures (e.g., scenarios, metrics, etc.) are output from the stated computing step and business decisions.

Abstract: Systems and methods for managing procurement risk are described. In accordance with a procurement risk management method, a resource sourcing mix is computed from a sourcing portfolio of one or more forward contracts, spot market purchases, and inventory depletion for each period of a planning horizon based on forecast scenarios for resource demand, resource price, and resource availability and a specified inventory carrying policy for the resource. Based upon the computed resource sourcing mix, one or more metrics for evaluating the sourcing portfolio are computed. A system and a computer program implementing the above-described procurement risk management method also are described.

Abstract: Methods, systems, and computer programs that enable procurement risk to be efficiently and effectively managed and evaluated are described. In one aspect, inputs specifying one or more forward contracts in a sourcing portfolio for procuring a resource from one or more suppliers are received. Inputs specifying one or more aspects of a target sourcing strategy for procuring the resource also are received. A procurement risk evaluation report comparing the sourcing portfolio and the target sourcing strategy is presented.

Abstract: Systems and methods for managing procurement risk are described. In accordance with a procurement risk management method, a resource sourcing mix is computed from a sourcing portfolio of one or more forward contracts, spot market purchases, and inventory depletion for each period of a planning horizon based on forecast scenarios for resource demand, resource price, and resource availability and a specified inventory carrying policy for the resource. Based upon the computed resource sourcing mix, one or more metrics for evaluating the sourcing portfolio are computed. A system and a computer program implementing the above-described procurement risk management method also are described.

Abstract: Methods, systems, and computer programs that enable procurement risk to be efficiently and effectively managed and evaluated are described. In one aspect, inputs specifying one or more forward contracts in a sourcing portfolio for procuring a resource from one or more suppliers are received. Inputs specifying one or more aspects of a target sourcing strategy for procuring the resource also are received. A procurement risk evaluation report comparing the sourcing portfolio and the target sourcing strategy is presented.

Abstract: The present invention includes a method and system for creating a price forecasting tool. The method includes receiving historical data related to a commodity, defining a long-run average price trend based on the received historical data and creating a price forecasting tool based on the long-run average price trend wherein the price forecasting tool is capable of taking into account a market momentum of the commodity in order to generate a plurality of scenario prices of the commodity for a plurality of forecast horizons. By utilizing the method and system in accordance with the present invention, a separate statistical model is developed for each forecast horizon, rather than developing a single period model that is then run through simulations to develop longer term forecast distributions.