Patents by Inventor Venu Reddy GURIJALA

Venu Reddy GURIJALA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
    Patent number: 10772971
    Abstract: The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: September 15, 2020
    Assignee: Mersana Therpeutics, Inc.
    Inventors: Venu Reddy Gurijala, Satyanarayan Reddy Bollu, Jacques Leblanc, Timothy B. Lowinger, Dennis McGillicuddy, Mao Yin, Aleksandr V. Yurkovetskiy
  • METHODS OF PRODUCING DRUG-CARRYING POLYMER SCAFFOLDS AND PROTEIN-POLYMER-DRUG CONJUGATES
    Publication number: 20180369405
    Abstract: The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.
    Type: Application
    Filed: June 22, 2018
    Publication date: December 27, 2018
    Inventors: Venu Reddy GURIJALA, Satyanarayan Reddy BOLLU, Jacques LEBLANC, Timothy B. LOWINGER, Dennis MCGILLICUDDY, Mao YIN, Aleksandr V. YURKOVETSKIY
  • PROTEIN-POLYMER-DRUG CONJUGATES
    Publication number: 20180140716
    Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.
    Type: Application
    Filed: November 16, 2017
    Publication date: May 24, 2018
    Inventors: Aleksandr V. YURKOVETSKIY, Mao YIN, Timothy B. LOWINGER, Joshua D. THOMAS, Cheri A. STEVENSON, Venu Reddy GURIJALA