Patents by Inventor Vera Ivanova

Vera Ivanova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Parenteral sustained-release delivery of carvedilol disperse systems
    Patent number: 10792244
    Abstract: Carvedilol parenteral sustained release systems by IV infusion, injection, or subcutaneous routes are disclosed. Preparation of carvedilol disperse systems such as liposomes, biodegradable microparticles or nanoparticles, and polymeric microparticles or nanoparticles have been presented in the present invention. Compositions containing carvedilol encapsulated in liposomes showed higher bioavailability and lower clearance rate than that of the free solution after intravenous administration. In vitro release of those liposomes in buffer solutions shows drug extended release over 48 hours, and correspondingly the in vivo animal data shows that parenteral administration of carvedilol encapsulated in liposomal materials has sustained release PK profile.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: October 6, 2020
    Assignee: ASCENDIA PHARMACEUTICALS, LLC.
    Inventors: Vera Ivanova, Kaoru Maeda, Wan Wang, Dongwei Guo, Jingjun Huang
  • PARENTERAL SUSTAINED-RELEASE DELIVERY OF CARVEDILOL DISPERSE SYSTEMS
    Publication number: 20200000706
    Abstract: Carvedilol parenteral sustained release systems by IV infusion, injection, or subcutaneous routes are disclosed. Preparation of carvedilol disperse systems such as liposomes, biodegradable microparticles or nanoparticles, and polymeric microparticles or nanoparticles have been presented in the present invention. Compositions containing carvedilol encapsulated in liposomes showed higher bioavailability and lower clearance rate than that of the free solution after intravenous administration. In vitro release of those liposomes in buffer solutions shows drug extended release over 48 hours, and correspondingly the in vivo animal data shows that parenteral administration of carvedilol encapsulated in liposomal materials has sustained release PK profile.
    Type: Application
    Filed: June 3, 2019
    Publication date: January 2, 2020
    Applicant: ASCENDIA PHARMACEUTICALS, LLC
    Inventors: Vera IVANOVA, Kaoru MAEDA, Wan WANG, Dongwei GUO, Jingjun HUANG
  • PARENTERAL SUSTAINED-RELEASE DELIVERY OF CARVEDILOL DISPERSE SYSTEMS
    Publication number: 20170354592
    Abstract: Carvedilol parenteral sustained release systems by IV infusion, injection, or subcutaneous routes are disclosed. Preparation of carvedilol disperse systems such as liposomes, biodegradable microparticles or nanparticles, and polymeric microparticles or nanparticles have been presented in the present invention. Compositions containing carvedilol encapsulated in liposomes showed higher bioavailability and lower clearance rate than that of the free solution after intravenous administration. In vitro release of those liposomes in buffer solutions shows drug extended release over 48 hours, and correspondingly the in vivo animal data shows that parenteral administration of carvedilol encapsulated in liposomal materials has sustained release PK profile.
    Type: Application
    Filed: June 13, 2017
    Publication date: December 14, 2017
    Applicant: ASCENDIA PHARMACEUTICALS, LLC
    Inventors: Vera IVANOVA, Kaoru MAEDA, Wan WANG, Dongwei GUO, Jingjun HUANG
  • Nanotechnology approach for inhalation therapies
    Patent number: 9445993
    Abstract: This invention relates to lipid nanoparticle compositions and methods for the localized delivery of active agents via inhalation therapy.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: September 20, 2016
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Tamara Minko, Olga B. Garbuzenko, Vera Ivanova
  • NANOTECHNOLOGY APPROACH FOR INHALATION THERAPIES
    Publication number: 20130273164
    Abstract: This invention relates to lipid nanoparticle compositions and methods for the localized delivery of active agents via inhalation therapy.
    Type: Application
    Filed: April 16, 2013
    Publication date: October 17, 2013
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Tamara Minko, Olga B. Garbuzenko, Vera Ivanova