Patents by Inventor Vera Rakhmanova
Vera Rakhmanova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8420402Abstract: The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.Type: GrantFiled: January 27, 2012Date of Patent: April 16, 2013Assignee: AnaSpec IncorporatedInventors: Jianjun He, Anita Hong, Qingheng Wang, Raman Khosrow Afshar, Ming Zhu, Vera Rakhmanova
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Publication number: 20120130057Abstract: The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.Type: ApplicationFiled: January 27, 2012Publication date: May 24, 2012Applicant: AnaSpec IncorporatedInventors: Jianjun He, Anita Hong, Qingheng Wang, Raman Khosrow Afshar, Ming Zhu, Vera Rakhmanova
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Patent number: 8129193Abstract: The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.Type: GrantFiled: July 28, 2010Date of Patent: March 6, 2012Assignee: AnaSpec IncorporatedInventors: Jianjun He, Anita Hong, Qingzheng Wang, Raman Khosrow Afshar, Ming Zhu, Vera Rakhmanova
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Publication number: 20110027900Abstract: The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.Type: ApplicationFiled: July 28, 2010Publication date: February 3, 2011Applicant: AnaSpec IncorporatedInventors: Jianjun He, Anita Hong, Qingzheng Wang, Raman Khosrow Afshar, Ming Zhu, Vera Rakhmanova
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Publication number: 20100279328Abstract: The present invention is generally directed to biological assays. More specifically it is directed to FRET-based assays using particularly effecting FRET pairs, methods for performing such assays and the molecules utilized in the assays. In a composition aspect, the present invention is directed to a FRET-based protease substrate selected from the list of substrates shown in the Detailed Description section above. In a method aspect, the present invention is directed to a method of performing a FRET-based assay, where the assay includes the following steps: adding a solution or suspension containing one or more different proteins to a reaction vessel; adding a liquid comprising a FRET-substrate to the reaction vessel, wherein the FRET-substrate is selected from the list of substrates shown in the Detailed Description section above. In a kit aspect, the present invention is directed to a kit for performing a FRET-based assay, wherein the kit comprises a protease substrate.Type: ApplicationFiled: February 5, 2010Publication date: November 4, 2010Inventors: Anita Hong, Vera Rakhmanova, Xiao-He Tong
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Publication number: 20100087468Abstract: The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.Type: ApplicationFiled: October 7, 2009Publication date: April 8, 2010Applicant: Metabolex, Inc.Inventors: Yan ZHU, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine M. Gregoire, Vera A. Rakhmanova
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Patent number: 7622491Abstract: The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.Type: GrantFiled: August 11, 2005Date of Patent: November 24, 2009Assignee: Metabolex Inc.Inventors: Yan Zhu, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine M. Gregoire, Vera A. Rakhmanova
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Publication number: 20080108630Abstract: The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.Type: ApplicationFiled: October 31, 2007Publication date: May 8, 2008Applicant: Metabolex Inc.Inventors: Yan Zhu, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine Gregoire, Vera Rakhmanova
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Patent number: 7323480Abstract: The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.Type: GrantFiled: May 24, 2005Date of Patent: January 29, 2008Assignee: Metabolex, Inc.Inventors: Yan Zhu, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine M. Gregoire, Vera A. Rakhmanova
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Publication number: 20060058301Abstract: The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.Type: ApplicationFiled: August 11, 2005Publication date: March 16, 2006Applicant: Metabolex, Inc.Inventors: Yan Zhu, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine Gregoire, Vera Rakhmanova
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Publication number: 20060014785Abstract: The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.Type: ApplicationFiled: May 24, 2005Publication date: January 19, 2006Applicant: Metabolex, Inc.Inventors: Yan Zhu, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine Gregoire, Vera Rakhmanova
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Publication number: 20060014809Abstract: The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.Type: ApplicationFiled: May 24, 2005Publication date: January 19, 2006Applicant: Metabolex, Inc.Inventors: Yan Zhu, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine Gregoire, Vera Rakhmanova