Abstract: The present invention discloses composition(s) for increasing the levels of tyrosine hydroxylase in the mammalian brain of human subjects and thus increasing the levels of brain catecholamines, in treating neurological related disorders. The composition(s) comprise(s) a biological extract obtained from the oil palm fruit bunch or aqueous stream of the processing or milling of oil palm fruit bunches. In an embodiment, the extract is obtained from the oil palm fruit bunch or aqueous stream of the processing or milling of oil palm fruit bunches. The extract is water-soluble. In another embodiment, the extract further comprises one or more organic compounds. The one or more organic compounds are selected from the group consisting of but not limited to sugars, phenolic compounds, flavonols, stilbenoids, dihydroflavonols, anthocyanins, shikimic acid, soluble fibres and peptides.

Abstract: Methods of evaluating agents for metakaryocidal and metakaryostatic activity in cell culture, explants and subjects are disclosed.