Patents by Inventor Vered Padler-Karavani

Vered Padler-Karavani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMANIZED ANTIBODIES AND FRAGMENTS THEREOF BINDING TO CARBOHYDRATE ANTIGENS AND USES THEREOF
    Publication number: 20240043561
    Abstract: The present invention discloses humanized monoclonal antibodies that specifically bind to SLeA carbohydrate antigen with high specificity and selectivity, functional fragments of the humanized monoclonal antibodies such as scFv, and chimeric antigen receptors comprising the humanized monoclonal antibodies or the fragment thereof such as scFv. The invention further provides cells and compositions comprising the antibodies, fragments thereof or CARs as well as their use in diagnostics and treatment of cancer.
    Type: Application
    Filed: November 23, 2021
    Publication date: February 8, 2024
    Inventors: Vered PADLER-KARAVANI, Ron AMON
  • ANTIBODIES TO CARBOHYDRATE ANTIGENS
    Publication number: 20230174664
    Abstract: The present invention discloses novel monoclonal antibodies and functional fragments thereof that specifically bind to SLeA carbohydrate antigen with high specificity and selectivity. The invention further provides compositions comprising the antibodies or fragments thereof as well as uses of the antibodies, fragments and compositions.
    Type: Application
    Filed: November 25, 2020
    Publication date: June 8, 2023
    Inventors: Vered PADLER-KARAVANI, Ron AMON, Ronit ROSENFELD
  • CHIMERIC ANTIGEN RECEPTOR TO CARBOHYDRATE ANTIGENS
    Publication number: 20230058044
    Abstract: The present invention discloses chimeric antigen receptors that specifically recognize and bind to SLe A carbohydrate antigen with high specificity and selectivity. The invention further provides lymphocytic cells, such as T cells, comprising said CARs, compositions comprising said cells or CARs as well as uses thereof.
    Type: Application
    Filed: November 25, 2020
    Publication date: February 23, 2023
    Inventors: Vered PADLER-KARAVANI, Yafit ATIYA-NASAGI, Ron AMON, Anat GLOBERSON LEVIN, Tova WAKS, Moran RAWET-SLOBODKIN, Lihi NINIO MANY, Zelig ESHHAR
  • ASSESSMENT OF DISEASE RISK FACTORS IN CORRELATION WITH NEU5GC INGESTED IN FOOD
    Publication number: 20220357337
    Abstract: The present invention discloses methods of identifying subject having an increased risk to develop an N-glycolylneu-raminic acid (Neu5Gc) related disease, methods for assessment risk factors related to a consumption of Neu5Gc from food and methods of predicting the likelihood of developing of Neu5Gc related disease or disorder.
    Type: Application
    Filed: June 17, 2020
    Publication date: November 10, 2022
    Inventors: Vered PADLER-KARAVANI, Salam BASHIR, Pilar GALAN, Leopold FEZEU
  • IMMUNOGENIC COMPOSITIONS CONTAINING N-GLYCOL YLNEURAMINIC ACID BEARING NANOPARTICLES
    Publication number: 20220031720
    Abstract: The present invention provides an active cancer vaccine and specifically an immunogenic compositions of membrane vesicles that serve as biomimetic nanoparticles derived from eukaryotic cell membranes that bear N-glycolylneuraminic acid glycoconjugates. These compositions can elicit beneficial immunological responses for treatment of Neu5Gc-positive tumors. The present invention provides methods of generating and using Neu5Gc-conjugated nanoparticles from eukaryotic cells membranes designated nano-ghosts.
    Type: Application
    Filed: November 21, 2019
    Publication date: February 3, 2022
    Inventors: Vered PADLER-KARAVANI, Eliran Moshe REUVEN, Shani LEVIATAN BEN-ARYE
  • Compositions and methods for detecting cancer
    Patent number: 9423401
    Abstract: The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: August 23, 2016
    Assignees: The Regents of the University of California, Siamab Therapeutics, Inc.
    Inventors: Ajit Varki, Richard B. Schwab, Vered Padler-Karavani, Nancy Hurtado-Ziola
  • Compositions and Methods for Detecting Cancer
    Publication number: 20140113979
    Abstract: The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer.
    Type: Application
    Filed: December 23, 2013
    Publication date: April 24, 2014
    Applicant: The Regents of the University of California
    Inventors: Ajit Varki, Richard B. Schwab, Vered Padler-Karavani, Nancy Hurtado-Ziola
  • COMPOSITIONS AND METHODS FOR DETECTING CANCER
    Publication number: 20110177614
    Abstract: The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer.
    Type: Application
    Filed: January 14, 2011
    Publication date: July 21, 2011
    Inventors: Ajit Varki, Richard B. Schwab, Vered Padler-Karavani, Nancy Hurtado-Ziola