Abstract: Disclosed are methods and structures for joining metallic members. A welding material can be used between two metallic members that comprise different metals. The different metals can normally form brittle intermetallic compounds when welded to one another, and the welding material can inhibit the formation of the brittle intermetallic compounds.

Abstract: A medical article that includes (a) an electronically conductive substrate having a specific conductivity of at least 1 ?S/cm and (b) a galvanic couple that includes a first member and a second member arranged in sufficient proximity to each other to generate a localized electric field under physiological conditions. The first and second members are selected such that the galvanic couple exhibits an average plateau current density of at least 25 microamps/cm2 when short circuited in a zero resistance ammeter test at room temperature using a saline electrolyte.

Abstract: An endoprosthesis, such as a stent, having a layer that can enhance the biocompatibility of the endoprosthesis, and methods of making the endoprosthesis are disclosed.

Abstract: An endoprosthesis, such as a stent, having a layer that can enhance the biocompatibility of the endoprosthesis, and methods of making the endoprosthesis are disclosed.

Abstract: Disclosed are methods and structures for joining metallic members. A welding material can be used between two metallic members that comprise different metals. The different metals can normally form brittle intermetallic compounds when welded to one another, and the welding material can inhibit the formation of the brittle intermetallic compounds.

Abstract: An endoprosthesis, such as a stent, having a layer that can enhance the biocompatibility of the endoprosthesis, and methods of making the endoprosthesis are disclosed.

Abstract: An endoprosthesis, such as a stent, having a layer that can enhance the biocompatibility of the endoprosthesis, and methods of making the endoprosthesis are disclosed.

Abstract: A medical article that includes (a) an electronically conductive substrate having a specific conductivity of at least 1 ?S/cm and (b) a galvanic couple that includes a first member and a second member arranged in sufficient proximity to each other to generate a localized electric field under physiological conditions. The first and second members are selected such that the galvanic couple exhibits an average plateau current density of at least 25 microamps/cm2 when short circuited in a zero resistance ammeter test at room temperature using a saline electrolyte.

Abstract: An endoprosthesis, such as a stent, having a layer that can enhance the biocompatibility of the endoprosthesis, and methods of making the endoprosthesis are disclosed.

Abstract: An endoprosthesis, such as a stent, having a layer that can enhance the biocompatibility of the endoprosthesis, and methods of making the endoprosthesis are disclosed.

Abstract: Distal protection filter frame and method for using and manufacturing the same. A distal protection filter frame may include one or more struts, a mouth, and a filter coupled to the mouth.

Abstract: Medical devices that include oxidizable portions can be plated after a two step activation process that includes successive applications of two aqueous solutions of ammonium bifluoride. Once plated, such materials can be soldered using conventional solders and fluxes. Medical devices can be assembled by soldering together plated materials. Oxidizable materials can be plated with radiopaque materials to yield medical devices that are more visible to fluoroscopy.

Abstract: Medical devices that include oxidizable portions can be plated after a two step activation process that includes successive applications of two aqueous solutions of ammonium bifluoride. Once plated, such materials can be soldered using conventional solders and fluxes. Medical devices can be assembled by soldering together plated materials. Oxidizable materials can be plated with radiopaque materials to yield medical devices that are more visible to fluoroscopy.

Abstract: An endoprosthesis, such as a stent, having a layer that can enhance the biocompatibility of the endoprosthesis, and methods of making the endoprosthesis are disclosed.

Abstract: An endoprosthesis, such as a stent, having a layer that can enhance the biocompatibility of the endoprosthesis, and methods of making the endoprosthesis are disclosed.

Abstract: A system for recanalizing an occluded blood vessel including a centering catheter employed to center an ablative guide wire within the blood vessel as the guide wire traverses the occlusion. The centering catheter includes a catheter body with an operative lumen through which the ablative guide wire is slidingly disposed. The centering catheter further includes a distally disposed centering mechanism that, when activated, centers the ablative guide wire within the blood vessel as it traverses the occlusion. The centering mechanism can comprise various embodiments including a single inflatable balloon or segmented inflatable balloon, which is in fluid communication with an inflation lumen. An airless preparation lumen may be disposed within the inflation lumen for ease of centering catheter preparation. The ablative guide wire includes insulation that is preferably formed of heat shrink tubing, which is stretched prior or concurrently with the heating process.

Abstract: An improved guide wire brake that is particularly suited to ablative rotational atherectomy devices is disclosed. The guide wire brake ensures that a guide wire is prevented from rotating or moving axially prior to activation of a primary mover such as a turbine. In one embodiment a pressure relief valve delays the activation of the prime mover on start up, and a check valve delays the release of the guide wire brake on shut down. In a second embodiment the guide wire brake is serially connected to the prime mover such that the prime mover is not connected to the pressurized gas source until after the guide wire brake is engaged. In a third embodiment a guide wire is disposed through a flexible tube within a rigid cylinder that is serially connected to the prime mover, such that when pressurized gas is provided to the prime mover the flexible tube will collapse on the guide wire, to prevent guide wire movement.

Abstract: An atherectomy burr having an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include a flexible polymeric tube that is plated with an abrasive and that expands when the burr is rotated. Metal fibers are embedded into burr to improve strength and to control the maximum expansion diameter of the burr. The abrasive is plated on the burr by first selectively exposing the underlying metal. The exposed metal is then plated with a layer of metal such as nickel having a slurry of diamond particles disposed therein using an electro and/or electroless plating method. When the burr is rotated, the polymeric tube expands by centrifugal force to ablate a new lumen in the patient's vessel.

Abstract: A system for recanalizing an occluded blood vessel including a centering catheter employed to center an ablative guide wire within the blood vessel as the guide wire traverses the occlusion. The centering catheter includes a catheter body with an operative lumen through which the ablative guide wire is slidingly disposed. The centering catheter further includes a distally disposed centering mechanism that, when activated, centers the ablative guide wire within the blood vessel as it traverses the occlusion. The centering mechanism can comprise various embodiments including a single inflatable balloon or segmented inflatable balloon, which is in fluid communication with an inflation lumen. An airless preparation lumen may be disposed within the inflation lumen for ease of centering catheter preparation. The ablative guide wire includes insulation that is preferably formed of heat shrink tubing, which is stretched prior or concurrently with the heating process.

Abstract: A system for recanalizing an occluded blood vessel including a centering catheter employed to center an ablative guide wire within the blood vessel as the guide wire traverses the occlusion. The centering catheter includes a catheter body with an operative lumen through which the ablative guide wire is slidingly disposed. The centering catheter further includes a distally disposed centering mechanism that, when activated, centers the ablative guide wire within the blood vessel as it traverses the occlusion. The centering mechanism can comprise various embodiments including a single inflatable balloon or segmented inflatable balloon, which is in fluid communication with an inflation lumen. An airless preparation lumen may be disposed within the inflation lumen for ease of centering catheter preparation. The ablative guide wire includes insulation that is preferably formed of heat shrink tubing, which is stretched prior or concurrently with the heating process.