Abstract: A novel process for making estra-4,9(10)-diene-3,17-dione steroids from readily available 19-nor-androst-4-ene-3-one steroids by a straightforward three-step process. Products of this process are important intermediates in the preparation of biologically active substances.

Abstract: A novel process for making estra-4,9(10)-diene-3,17-dione steroids from readily available 19-nor-androst-4-ene-3-one steroids by a straightforward three-step process. Products of this process are important intermediates in the preparation of biologically active substances.

Abstract: A novel process for making estra-4,9(10)-diene-3,17-dione steroids from readily available 19-nor-androst-4-ene-3-one steroids by a straightforward three-step process. Products of this process are important intermediates in the preparation of biologically active substances.

Abstract: Using cyanohydrin intermediates, 17-keto steroids are transformed to corticoids and 17.alpha.-acyl progesterones.

Abstract: The process of the present invention uses an amine to prepare monolithium acetylide which is sufficiently stable at up to 0.degree. and yet is sufficiently reactive to react with 16-substituted-17-keto steroids producing the useful 17.alpha.-ethynyl-17.beta.-hydroxy-16-substituted steroids.

Abstract: The present invention relates to processes for the conversion of a 3-protected steroidal 17-ketone to a 17-spiro-.gamma.-lactone having the appropriate 17-stereochemistry for spironolactone. Novel intermediates (II, II', II", II'", II.sup.a, II.sup.b, II.sup.c, II.sup.d, II.sub.x, II'.sub.x and II".sub.x) are also disclosed.

Abstract: .DELTA..sup.4 -3-keto, .DELTA..sup.1,4 -3-keto and 3.beta.-hydroxy 17-keto steroids (I) are transformed into the corresponding 16-.beta.-methyl-17-keto steroids (IV) by first activating the C-16 position, then methylating. By protecting the C-3 position of the .DELTA..sup.4 -3-keto and 3.beta.-hydroxy steroids the yields are greatly increased.

Abstract: 17.alpha.-Hydroxy-6,16-dimethylenepregn-4-ene-3,20-dione simultaneously isomerized and acylated to 17.alpha.-hydroxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione 17-acetate.

Abstract: The process of the invention permits acylation of hindered steroidal tertiary alcohols without the undesirable side reactions which accompany previously known acylation reactions.

Abstract: A process for preparing optically active 2(S) or 2(R) tricyclic lactone glycols of the formula ##STR1## wherein W is 1-pentyl, 1-pent-cis-2-enyl, or 1-pent-2-ynyl. This process is useful for preparing stereospecifically prostaglandins having pharmacological utility.

Abstract: This invention discloses a general process for the production of corticoids from androstenes. This invention provides an economically viable alternative synthesis of 17.alpha.-hydroxyprogesterones and the corticoids.

Abstract: Process for preparing lactones of the formula ##SPC1##Wherein G is R.sub.9, 1-hydroxyhexyl, or 1-hydroxy-cis-3-hexenyl, wherein R.sub.9 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 alkyl of one to 4 carbon atoms, inclusive; wherein M is hydrogen or a blocking group; wherein R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, or ethyl substituted in the .beta.-position with 3 chloro, 2 or 3 bromo, or 1, 2, or 3 iodo; and wherein .about. indicates attachment in alpha or beta configuration. The lactones are useful intermediates in preparing prostaglandins having pharmacological utility.

Abstract: Tricyclic lactone glycol sulfonates of the formula ##SPC1##Or ##SPC2##Wherein R.sub.3 is alkyl of one to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one or 2 halo or alkyl of one to 4 carbon atoms, inclusive;Wherein R.sub.4 is alkyl of one to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one or 2 halo or alkyl of one to 4 carbon atoms, inclusive; andWherein W is 1-pentyl, 1-pent-cis-2-enyl, or 1-pent-2-ynyl.These compounds are useful in preparing stereo-specifically prostaglandins having pharmacological utility.