Patents by Inventor Vern G. DeVries

Vern G. DeVries has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
    Patent number: 5373020
    Abstract: The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.
    Type: Grant
    Filed: June 3, 1993
    Date of Patent: December 13, 1994
    Assignee: American Cyanamid Company
    Inventors: Jonathan D. Bloom, Thomas H. Claus, Vern G. DeVries, Jo A. Dolan, Minu D. Dutia
  • Substituted 5-(2-(2-aryl-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxoles
    Patent number: 5245053
    Abstract: A process is disclosed for obtaining the R,R isomer of: ##STR1## wherein R.sub.1 and R.sub.2 may be one or more groups which may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, halogen, trifluoromethyl, carboxy, hydroxyalkyl, alkoxycarbonyl, C.sub.1 to C.sub.4 thioalkyl, sulfonyl and sulfinyl; X is a divalent radical consisting of ##STR2## wherein R' is hydrogen; R.sub.2 and R.sub.3 may be the same or different and are selected from the group consisting of hydrogen and C.sub.1 to C.sub.4 alkyl; R.sub.5 and R.sub.6 are selected from the group consisting of hydrogen, carboxy, alkoxycarbonyl, hydroxymethyl, --CH.sub.2 OCH.sub.2 COOR.sub.7 and --CH.sub.2 OCH.sub.2 CH.sub.2 OR.sub.7 where R.sub.7 is hydrogen or C.sub.1 to .sub.4 alkyl; except that R.sub.5 and R.sub.
    Type: Grant
    Filed: June 10, 1992
    Date of Patent: September 14, 1993
    Assignee: American Cyanamid Company
    Inventors: Jonathan D. Bloom, Thomas H. Claus, Vern G. Devries, Jo A. Dolan, Minu D. Dutia
  • Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
    Patent number: 5151439
    Abstract: The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.
    Type: Grant
    Filed: August 1, 1991
    Date of Patent: September 29, 1992
    Assignee: American Cyanamid Company
    Inventors: Jonathan D. Bloom, Thomas H. Claus, Vern G. DeVries, Jo A. Dolan, Minu D. Dutia
  • Method of increasing lean meat in edible animals
    Patent number: 5106867
    Abstract: The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.
    Type: Grant
    Filed: April 5, 1991
    Date of Patent: April 21, 1992
    Assignee: American Cyanamid Company
    Inventors: Jonathan D. Bloom, Thomas H. Claus, Vern G. DeVries, Jo A. Dolan, Minu D. Dutia
  • Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
    Patent number: 5061727
    Abstract: The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.
    Type: Grant
    Filed: May 4, 1990
    Date of Patent: October 29, 1991
    Assignee: American Cyanamid Company
    Inventors: Jonathan D. Bloom, Thomas H. Claus, Vern G. DeVries, Jo A. Dolan, Minu D. Dutia
  • Antidiabetic phosphates
    Patent number: 4968790
    Abstract: Phosphates are disclosed which stimulate the enzyme fructose-1,6-bisphosphatase and inhibit the enzyme 6-phosphofructo-1-kinase, thereby lowering glucose levels in mammals. These phosphates may thus be used to treat hyperglycemia and/or diabetes. Processes for the synthesis of the phosphates are also disclosed.
    Type: Grant
    Filed: October 28, 1988
    Date of Patent: November 6, 1990
    Assignee: American Cyanamid Company
    Inventors: Vern G. DeVries, Thomas H. Claus, Middleton B. Floyd, Jr., Semiramis Ayral-Kaloustian
  • Antidiabetic phosphonates
    Patent number: 4945158
    Abstract: Phosphonates are disclosed which stimulate the enzyme fructose-1,6-bisphosphatase and inhibit the enzyme 6-phosphofructo-1-kinase, thereby lowering glucose levels in mammals. These phosphonates may thus be used to treat hyperglycemia and/or diabetes. Processes for the synthesis of the phosphonates are also disclosed.
    Type: Grant
    Filed: August 12, 1988
    Date of Patent: July 31, 1990
    Assignee: American Cyanamid Company
    Inventors: Vern G. DeVries, Thomas H. Claus, Middleton B. Floyd, Jr., Semiramis Ayral-Kaloustian
  • Antidiabetic alpha-substituted phosphonates
    Patent number: 4943629
    Abstract: Alpha-substituted phosphonates are disclosed which stimulate the enzyme fructose-1,6-bisphosphatase and inhibit the enzyme 6-phosphofructo-1-kinase, thereby lowering glucose levels in mammals. These alpha-substituted phosphonates may thus be used to treat hyperglycemia and/or diabetes. Processes for the synthesis of the alpha-substituted phosphonates are also disclosed.
    Type: Grant
    Filed: August 12, 1988
    Date of Patent: July 24, 1990
    Assignee: American Cyanamid Company
    Inventors: Vern G. DeVries, Thomas H. Claus, Middleton B. Floyd, Jr., Semiramis Ayral-Kaloustian
  • Antiatherosclerotic silanes
    Patent number: 4670421
    Abstract: This invention is concerned with novel 4-[(trialkylsilyl)alkylamino]phenyl compounds and their use as antiatherosclerotic agents.
    Type: Grant
    Filed: July 12, 1982
    Date of Patent: June 2, 1987
    Assignee: American Cyanamid Company
    Inventors: Vern G. DeVries, Janis Upeslacis
  • Antiatherosclerotic diphenyl alkanamides
    Patent number: 4603145
    Abstract: This disclosure describes novel diaryl-alkanamides. These compounds are useful as pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: July 29, 1986
    Assignee: American Cyanamid Company
    Inventors: Vern G. DeVries, Robert G. Shepherd, Janis Upeslacis
  • Arylglyoxals
    Patent number: 4592876
    Abstract: Arylglyoxals which are new compounds, active as hypoglycemic agents.
    Type: Grant
    Filed: July 16, 1984
    Date of Patent: June 3, 1986
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Vern G. DeVries
  • Dibenzocycloalkanamido and dibenzothioxanthenyl benzoic acids
    Patent number: 4489090
    Abstract: This disclosure describes novel dibenzocycloalkanamido-benzoic acids and esters. Also described are dibenzothioxanthenyl-benzoic acids and esters. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial walls of mammals.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: December 18, 1984
    Assignee: American Cyanamid Company
    Inventors: Vern G. DeVries, Robert G. Shepherd
  • Arylglyoxals useful as hypoglycemic agents
    Patent number: 4485114
    Abstract: Arylglyoxals which are new compounds, which are active as hypoglycemic agents.
    Type: Grant
    Filed: January 20, 1983
    Date of Patent: November 27, 1984
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Vern G. DeVries
  • Arylglyoxals
    Patent number: 4474809
    Abstract: Arylglyoxals which are new compounds active as hypoglycemic agents.
    Type: Grant
    Filed: January 20, 1983
    Date of Patent: October 2, 1984
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Vern G. DeVries
  • Arylglyoxals and their pharmaceutical use
    Patent number: 4474810
    Abstract: Arylglyoxals which are new compounds, active as hypoglycemic agents.
    Type: Grant
    Filed: January 27, 1983
    Date of Patent: October 2, 1984
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Vern G. DeVries
  • Antiatherosclerotic tetrasubstituted ureas and thioureas
    Patent number: 4473579
    Abstract: Tetrasubstituted urea and thiourea compounds useful as antiatherosclerotic agents, compositions thereof and processes for their preparation.
    Type: Grant
    Filed: January 26, 1982
    Date of Patent: September 25, 1984
    Assignee: American Cyanamid Company
    Inventors: Vern G. Devries, Ransom B. Conrow
  • Method of treating atherosclerosis with trisubstituted ureas
    Patent number: 4397868
    Abstract: Methods of treating atherosclerosis with trisubstituted ureas, compositions thereof and processes for their preparation.
    Type: Grant
    Filed: January 26, 1982
    Date of Patent: August 9, 1983
    Assignee: American Cyanamid Company
    Inventor: Vern G. DeVries
  • Methods of treating atherosclerosis with dialkylureas and dialkylthioureas
    Patent number: 4387105
    Abstract: Method of treating atherosclerosis with dialkylureas and dialkylthioureas, compositions thereof and processes for their preparation.
    Type: Grant
    Filed: January 26, 1982
    Date of Patent: June 7, 1983
    Assignee: American Cyanamid Company
    Inventors: Vern G. DeVries, Elwood E. Largis