Abstract: Methods of treating an elastomeric substrate that include, in any suitable order, providing an elastomeric substrate in a bath including an alcohol and an alkaline material at a bath temperature effective for treatment, providing ultrasonic energy at a treatment-effective frequency and power level to the bath for a time period sufficient to treat the elastomeric substrate, rinsing the treated elastomeric substrate with de-ionized water, and drying the rinsed and treated elastomeric substrate are described.

Abstract: A laminate assembly, comprising a base sheet having at least one blister formed therein, a pharmaceutical composition displaced in said blister, a lid sheet bonded to said base sheet to form a primary seal therebetween, thus forming a primarily sealed laminate assembly; said primary sealed laminate assembly having a secondary seal formed therein, and related manufacturing method and system of manufacture.