Patents by Inventor Vernon G. Pursel

Vernon G. Pursel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Artificial liver device
    Patent number: 5866420
    Abstract: Continuous cultures of pluripotent parenchymal hepatocytes were derived from the epiblasts of pig blastocysts. The cultures are feeder-dependent and grow slowly with doubling times of 3 to 4 days. They differentiate into large secretory duct-like structures or form small canaliculi. In combination with feeder cells and, optionally, adult pig hepatocytes and macrophages, the cells are useful in an artificial liver device which may be utilized as temporary liver support for the mitigation of the pathological effects of liver failure.
    Type: Grant
    Filed: July 1, 1996
    Date of Patent: February 2, 1999
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Neil C. Talbot, Christopher W. Kemp, Thomas J. Caperna, Caird E. Rexroad, Jr., Vernon G. Pursel, Anne M. Powell
  • Hepatocyte cell line derived from the epiblast of pig blastocysts
    Patent number: 5532156
    Abstract: Continuous cultures of pluripotent parenchymal hepatocytes were derived from the epiblasts of pig blastocysts. The cultures are feeder-dependent and grow slowly with doubling times of 3 to 4 days. They differentiate into large secretory duct-like structures or form small canaliculi. Alternatively, the cells accumulate droplets that stain intensely with oil red O, a lipid-specific stain. .alpha.-Fetoprotein and albumin mRNA expression increases as the cells differentiate in culture.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: July 2, 1996
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Neil Talbot, Caird E. Rexroad, Jr., Vernon G. Pursel, Anne M. Powell