Patents by Inventor Vernon Knight
Vernon Knight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080248095Abstract: The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.Type: ApplicationFiled: January 25, 2008Publication date: October 9, 2008Inventors: Beppino C. Giovanella, J. Vernon Knight, J. Clifford Waldrep, Nedezhda Koshkina, Brian Gilbert, Clyde W. Wellen
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Publication number: 20080248096Abstract: Provided herein is a method of treating primary lung cancer or metastatic cancer to the lung in an individual by delivering at least once to the respiratory tract of the individual via inhalation a nebulized liposomal aerosol comprising a dilauroylphosphatidylcholine liposome containing camptothecin or a derivative thereof in an amount sufficient to deliver a pharmacologically effective dose of the camptothecin or its derivative to treat the cancer. Also provided is a nebulized liposomal aerosol comprising the DLPC containing the camptothecin or its derivative and a method of making the liposome-drug comprising the aerosol.Type: ApplicationFiled: January 25, 2008Publication date: October 9, 2008Inventors: Claire F. Verschraegen, J. Vernon Knight, Nadezhda Koshkina, Brian Gilbert
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Patent number: 7348025Abstract: Provided herein is a method of treating primary lung cancer or metastatic cancer to the lung in an individual by delivering at least once to the respiratory tract of the individual via inhalation a nebulized liposomal aerosol comprising a dilauroylphosphatidylcholine liposome containing camptothecin or a derivative thereof in an amount sufficient to deliver a pharmacologically effective dose of the camptothecin or its derivative to treat the cancer. Also provided is a nebulized liposomal aerosol comprising the DLPC containing the camptothecin or its derivative and a method of making the liposome-drug comprising the aerosol.Type: GrantFiled: September 16, 2003Date of Patent: March 25, 2008Assignee: Research Development FoundationInventors: J. Vernon Knight, Nadezhda Koshkina, Brian Gilbert, Claire F. Verschraegen
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Patent number: 7341739Abstract: The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.Type: GrantFiled: May 11, 2004Date of Patent: March 11, 2008Assignee: Research Development FoundationInventors: Beppino C. Giovanella, J. Vernon Knight, J. Clifford Waldrep, Nadezhda Koshkina, Brian Gilbert, Clyde W. Wellen
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Patent number: 7288243Abstract: The present invention provides a method of inhibiting growth of lung metastases in an individual comprising the steps of administering a dose of a lipid-drug enhancer liposomal complex and, in sequence, administering a dose of a lipid-anticancer drug liposomal complex. Furthermore, the lipid-drug enhancer liposomal complex may be administered in a continuing dose with the lipid-anticancer drug liposomal complex whereby both liposomal complexes are mixed in the nebulizer. Methods of inhibiting growth of lung metastases in an individual by the sequential administration via aerosolization of a dilauroylphosphatidylcholine-cyclosporin A liposomal complex and a dilauroylphosphatidylcholine-paclitaxel liposomal complex are also provided.Type: GrantFiled: May 16, 2003Date of Patent: October 30, 2007Assignee: Research Development FoundationInventors: J. Vernon Knight, J. Clifford Waldrep, Nadezhda Koshkina
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Publication number: 20040208935Abstract: The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.Type: ApplicationFiled: May 11, 2004Publication date: October 21, 2004Applicant: Research Development FoundationInventors: Beppino C. Giovanella, J. Vernon Knight, J. Clifford Waldrep, Nadezhda Koshkina, Brian Gilbert, Clyde W. Wellen
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Publication number: 20040043958Abstract: The present invention provides a method of increasing the cellular expression of a gene in a biological tissue after delivery of said gene to an animal, comprising the step of: administering to said animal a pharmacologically effective dose of a glucocorticoid in an amount sufficient to increase the cellular expression of said gene. Also provided is a various method of treating a pathophysiological state in a human by increasing cellular expression of a gene after delivery of said gene into a biological tissue of an animal in need of such treatment, comprising the step of: administering to said animal a pharmacologically effective dose of a glucocorticoid in an amount sufficient to increase the cellular expression of said gene.Type: ApplicationFiled: September 19, 2003Publication date: March 4, 2004Applicant: Research Development FoundationInventors: Lindsay Schwarz, Vernon Knight, Jennifer Johnson
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Publication number: 20040028616Abstract: The present invention provides a method of inhibiting growth of lung metastases in an individual comprising the steps of administering in a combination an aerosolized polyethylenimine-DNA complex and an aerosolized liposome-anticancer drug complex with both of the complexes delivered via aerosolization. Delivery of both the DNA and the anticancer drug via this method inhibits growth of lung metastases in the individual. Also provided is a method of inhibiting growth of lung metastases in an individual by the administration in combination via aerosolization of a polyethylenimine-p53 complex and a dilauroylphosphatidylcholine-9-nitrocamptothecin complex.Type: ApplicationFiled: February 14, 2003Publication date: February 12, 2004Inventors: J. Vernon Knight, Brian Gilbert, Nadezhda Koshkina, L. Clifford Waldrep, Charles L. Densmore, Ajay Gautam
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Publication number: 20030236301Abstract: The present invention provides a method for treating a cell proliferative disease by delivering a composition comprising a vitamin E based anti-cancer compound contained within a delivery vesicle of an individual in need of such treatment where the compound has a structural formula 1Type: ApplicationFiled: December 19, 2002Publication date: December 25, 2003Inventors: Bob Sanders, Kimberly Kline, Karla A. Lawson, J. Vernon Knight, Marla S. Menchaca, Clyde W. Wellen
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Patent number: 6656916Abstract: The present invention provides a method of increasing the cellular expression of a gene in a biological tissue after delivery of said gene to an animal, comprising the step of: administering to said animal a pharmacologically effective dose of a glucocorticoid in an amount sufficient to increase the cellular expression of said gene. Also provided is a various method of treating a pathophysiological state in a human by increasing cellular expression of a gene after delivery of said gene into a biological tissue of an animal in need of such treatment, comprising the step of: administering to said animal a pharmacologically effective dose of a glucocorticoid in an amount sufficient to increase the cellular expression of said gene.Type: GrantFiled: September 6, 1996Date of Patent: December 2, 2003Assignee: Research Development FoundationInventors: Lindsay Schwarz, Vernon Knight, Jennifer Lee Johnson
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Publication number: 20030215494Abstract: The present invention provides a method of inhibiting growth of lung metastases in an individual comprising the steps of administering a dose of a lipid-drug enhancer liposomal complex and, in sequence, administering a dose of a lipid-anticancer drug liposomal complex. Furthermore, the lipid-drug enhancer liposomal complex may be administered in a continuing dose with the lipid-anticancer drug liposomal complex whereby both liposomal complexes are mixed in the nebulizer. Methods of inhibiting growth of lung metastases in an individual by the sequential administration via aerosolization of a dilauroylphosphatidylcholine-cyclosporin A liposomal complex and a dilauroylphosphatidylcholine-paclitaxel liposomal complex are also provided.Type: ApplicationFiled: May 16, 2003Publication date: November 20, 2003Inventors: J. Vernon Knight, J. Clifford Waldrep, Nadezhda Koshkina
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Patent number: 6440393Abstract: The present invention provides a method of increasing the deposition of aerosolized drug in the respiratory tract of an individual or animal, comprising the step of administering said aerosolized drug in an air mixture containing up to about 10% carbon dioxide gas.Type: GrantFiled: December 4, 2000Date of Patent: August 27, 2002Assignee: Research Development FoundationInventors: J. Clifford Waldrep, J. Vernon Knight, Nadezhda Koshkina
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Publication number: 20020106330Abstract: The present invention provides a method of increasing the deposition of aerosolized drug in the respiratory tract of an individual or animal, comprising the step of administering said aerosolized drug in an air mixture containing up to about 10% carbon dioxide gas.Type: ApplicationFiled: December 4, 2000Publication date: August 8, 2002Inventors: J. Clifford Waldrep, J. Vernon Knight, Nadezhda Koshkina
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Publication number: 20020102296Abstract: The small particle liposome or lipid complex aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes or other lipid complexes. The liposomes and complexes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10,11 -methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.Type: ApplicationFiled: October 1, 2001Publication date: August 1, 2002Applicant: Research Development FoundationInventors: Beppino C. Giovanella, J. Vernon Knight, J. Clifford Waldrep, Nadezhda Koshkina, Brian Gilbert, Clyde W. Wellen
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Patent number: 6375980Abstract: The present invention provides a liposomal aerosol composition, comprising a pharmaceutical compound, a cationic lipid, a neutral co-lipid; and tryptone. Also provided is a nebulized cationic lipid: neutral co-lipid: DNA suspension useful for lipid-DNA transfections, wherein the cationic lipid is bis(guanidinium)-tren-cholesterol and the neutral co-lipid is dioleoylphosphatidylethanolamine (DOPE).Type: GrantFiled: July 19, 1999Date of Patent: April 23, 2002Assignee: Research Development FoundationInventors: Charles L. Densmore, Jr., J. Vernon Knight, J. Clifford Waldrep, Berma M. Kinsey
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Publication number: 20020020412Abstract: The present invention is directed to a jet nebulizer assembly for administering drugs via aerosols in a patient's home and a method of treating a cancer in a patient's home by utilizing the jet nebulizer assembly.Type: ApplicationFiled: July 31, 2001Publication date: February 21, 2002Inventors: Brian E. Gilbert, J. Vernon Knight, Claire F. Verschraegen
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Patent number: 6346233Abstract: The small particle liposome or lipid complex aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes or other lipid complexes. The liposomes and complexes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.Type: GrantFiled: July 17, 2000Date of Patent: February 12, 2002Assignee: Research Development FoundationInventors: J. Vernon Knight, J Clifford Waldrep, Nadezhda Koshkina, Brian Gilbert
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Patent number: 6106859Abstract: The present invention provides a liposomal aerosol composition, comprising a pharmaceutical compound, a cationic lipid, (c) a neutral co-lipid; and (d) tryptone. Also provided is a nebulized cationic lipid:DNA suspension useful for lipid-DNA transfections, wherein said cationic lipid is bis(guanidinium)-tren-cholesterol.Type: GrantFiled: January 8, 1999Date of Patent: August 22, 2000Inventors: Charles L. Densmore, Jr., J. Vernon Knight, J. Clifford Waldrep, Berma M. Kinsey
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Patent number: 6090407Abstract: The small particle liposome or lipid complex aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes or other lipid complexes. The liposomes and complexes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.Type: GrantFiled: September 23, 1997Date of Patent: July 18, 2000Assignee: Research Development FoundationInventors: J. Vernon Knight, Brian Gilbert, J. Clifford Waldrep, Nadezhda Koshkina
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Patent number: RE40300Abstract: The present invention provides a method of increasing the deposition of aerosolized drug in the respiratory tract of an individual or animal, comprising the step of administering said aerosolized drug in an air mixture containing up to about 10% carbon dioxide gas.Type: GrantFiled: August 26, 2004Date of Patent: May 6, 2008Assignee: Research Development FoundationInventors: J. Clifford Waldrep, J. Vernon Knight, Nadezhda Koshkina