Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD1091B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: Dynamically customized animatable 3D models of virtual characters (“avatars”) in electronic messaging are provided. Users of instant messaging are represented dynamically by customized animatable 3D models of a corresponding virtual character. An example method comprises receiving input from a mobile device user, the input being an audio stream and/or an image/video stream; and based on an animatable 3D model and the streams, automatically generating a dynamically customized animatable 3D model corresponding to the user, including performing dynamic conversion of the input into an expression stream and corresponding time information. The example method includes generating a link to the expression stream and corresponding time information, for transmission in an instant message, and causing display of the customized animatable 3D model. Link generation and causing display is performed automatically or in response to user action.

Abstract: Exemplary embodiments include a computer-implemented method of training a neural network for facial reconstruction including collecting a set of 3D head scans, combining each feature of each 3D head scan with a weight to create a modified set of 3D head scans, training the neural network using the modified set of head scans, and inputting a real digital facial image into the neural network for facial reconstruction. Further exemplary embodiments include the set of 3D head scans comprising approximately a tenth or less in quantity in comparison to a quantity of the modified set of 3D head scans. The modified set of 3D head scans may comprise features found in the set of 3D head scans or the modified set of 3D head scans may consist of features found in the set of 3D head scans.

Abstract: Dynamically customized animatable 3D models of virtual characters (“avatars”) are generated in real time from multiple inputs from one or more devices having various sensors. Each input may comprise a point cloud associated with a user's face/head. An example method comprises receiving inputs from sensor data from multiple sensors of the device(s) in real time, and pre-processing the inputs for determining orientation of the point clouds. The method may include registering the point clouds to align them to a common reference; automatically detecting features of the point clouds; deforming a template geometry based on the features to automatically generate a custom geometry; determining a texture of the inputs and transferring the texture to the custom geometry; deforming a template control structure based on the features to automatically generate a custom control structure; and generating an animatable object having the custom geometry, the transferred texture, and the custom control structure.

Abstract: The disclosure provides methods and systems for automatically generating an animatable object, such as a 3D model. In particular, the present technology provides fast, easy, and automatic animatable solutions based on unique facial characteristics of user input. Various embodiments of the present technology include receiving user input, such as a two-dimensional image or three-dimensional scan of a user's face, and automatically detecting one or more features. The methods and systems may further include deforming a template geometry and a template control structure based on the one or more detected features to automatically generate a custom geometry and custom control structure, respectively. A texture of the received user input may also be transferred to the custom geometry. The animatable object therefore includes the custom geometry, the transferred texture, and the custom control structure, which follow a morphology of the face.

Abstract: The disclosure provides methods and systems for automatically generating an animatable object, such as a 3D model. In particular, the present technology provides fast, easy, and automatic animatable solutions based on unique facial characteristics of user input. Various embodiments of the present technology include receiving user input, such as a two-dimensional image or three-dimensional scan of a user's face, and automatically detecting one or more features. The methods and systems may further include deforming a template geometry and a template control structure based on the one or more detected features to automatically generate a custom geometry and custom control structure, respectively. A texture of the received user input may also be transferred to the custom geometry. The animatable object therefore includes the custom geometry, the transferred texture, and the custom control structure, which follow a morphology of the face.

Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: The invention relates to UBE3A protein targets and their usage as target engagement biomarkers for compounds that modulate ube3a expression.

Abstract: Dynamically customized animatable 3D models of virtual characters (“avatars”) are generated in real time from multiple inputs from one or more devices having various sensors. Each input may comprise a point cloud associated with a user's face/head. An example method comprises receiving inputs from sensor data from multiple sensors of the device(s) in real time, and pre-processing the inputs for determining orientation of the point clouds. The method may include registering the point clouds to align them to a common reference; automatically detecting features of the point clouds; deforming a template geometry based on the features to automatically generate a custom geometry; determining a texture of the inputs and transferring the texture to the custom geometry; deforming a template control structure based on the features to automatically generate a custom control structure; and generating an animatable object having the custom geometry, the transferred texture, and the custom control structure.

Abstract: Dynamically customized animatable 3D models of virtual characters (“avatars”) are generated in real time from multiple inputs from one or more devices having various sensors. Each input may comprise a point cloud associated with a user's face/head. An example method comprises receiving inputs from sensor data from multiple sensors of the device(s) in real time, and pre-processing the inputs for determining orientation of the point clouds. The method may include registering the point clouds to align them to a common reference; automatically detecting features of the point clouds; deforming a template geometry based on the features to automatically generate a custom geometry; determining a texture of the inputs and transferring the texture to the custom geometry; deforming a template control structure based on the features to automatically generate a custom control structure; and generating an animatable object having the custom geometry, the transferred texture, and the custom control structure.

Abstract: Dynamically customized animatable 3D models of virtual characters (“avatars”) in electronic messaging are provided. Users of instant messaging are represented dynamically by customized animatable 3D models of a corresponding virtual character. An example method comprises receiving input from a mobile device user, the input being an audio stream and/or an image/video stream; and based on an animatable 3D model and the streams, automatically generating a dynamically customized animatable 3D model corresponding to the user, including performing dynamic conversion of the input into an expression stream and corresponding time information. The example method includes generating a link to the expression stream and corresponding time information, for transmission in an instant message, and causing display of the customized animatable 3D model. Link generation and causing display is performed automatically or in response to user action.

Abstract: The present invention relates to antisense oligonucleotides (oligomers) complementary to nucleic acids encoding mammalian T cell-restricted intracellular antigen-1 (TIA1), in particular antisense oligonucleotides targeting TIA1 pre-mRNA sequences, which are capable of inhibiting the expression of TIA1. Inhibition of TIA1expression is beneficial for a range of medical disorders including neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) or Frontotemporal Dementia.

Abstract: Dynamically customized animatable 3D models of virtual characters (“avatars”) in electronic messaging are provided. Users of instant messaging are represented dynamically by customized animatable 3D models of a corresponding virtual character. An example method comprises receiving input from a mobile device user, the input being an audio stream and/or an image/video stream; and based on an animatable 3D model and the streams, automatically generating a dynamically customized animatable 3D model corresponding to the user, including performing dynamic conversion of the input into an expression stream and corresponding time information. The example method includes generating a link to the expression stream and corresponding time information, for transmission in an instant message, and causing display of the customized animatable 3D model. Link generation and causing display is performed automatically or in response to user action.

Abstract: The disclosure provides methods and systems for automatically generating an animatable object, such as a 3D model. In particular, the present technology provides fast, easy, and automatic animatable solutions based on unique facial characteristics of user input. Various embodiments of the present technology include receiving user input, such as a two-dimensional image or three-dimensional scan of a user's face, and automatically detecting one or more features. The methods and systems may further include deforming a template geometry and a template control structure based on the one or more detected features to automatically generate a custom geometry and custom control structure, respectively. A texture of the received user input may also be transferred to the custom geometry. The animatable object therefore includes the custom geometry, the transferred texture, and the custom control structure, which follow a morphology of the face.

Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.