Patents by Inventor Veronica M. Juan

Veronica M. Juan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-2 MUTEINS FOR TREATING CANCER OR INFECTION
    Publication number: 20240309061
    Abstract: Provided herein are IL-2 muteins that bind to the IL-2 receptor ? subunit but do not have measurable binding to the IL-2 receptor a subunit. Also provided are compositions, kits, methods, and uses involving such IL-2 muteins.
    Type: Application
    Filed: July 21, 2022
    Publication date: September 19, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Juan C. Alvarez, Alan C. Cheng, Ghassan N. Fayad, Brian E. Hall, Veronica M. Juan, Peter S. Kim, Sheila H. Ranganath, Venkataraman Sriraman, Gary C. Starling, Nicole C. Walsh
  • PROTEINS BINDING NKG2D, CD16, AND CEACAM5
    Publication number: 20240124607
    Abstract: Multi-specific binding proteins that bind NKG2D, CD16, and CEACAM5 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer
    Type: Application
    Filed: August 8, 2023
    Publication date: April 18, 2024
    Inventors: Amy M. Beebe, Laurence Fayadat-Dilman, Veronica M. Juan, Gregory P. Chang, Souvik Chattopadhyay, Ann F. Cheung, Asya Grinberg, Pyae P. Hein, Nicolai Wagtmann
  • IL-2 MUTEINS FOR TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES
    Publication number: 20240043491
    Abstract: Provided herein are IL-2 muteins that bind to IL-2 receptor subunit but do not have measurable binding to IL-2 receptor subunit. Also provided are compositions, kits, methods, and uses involving such IL-2 muteins.
    Type: Application
    Filed: December 21, 2021
    Publication date: February 8, 2024
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: Stephen E. ALVES, Glareh AZADI, Maribel BEAUMONT, Lia BENSO, Alan C. CHENG, Peter GEORGIEV, Brian E. HALL, Veronica M. JUAN, Renee MOORE, Venkataraman SRIRAMAN, Jie ZHANG-HOOVER
  • AFFINITY MATURED ANTI-LAP ANTIBODIES AND USES THEREOF
    Publication number: 20230272056
    Abstract: Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
    Type: Application
    Filed: April 8, 2021
    Publication date: August 31, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Chung-Ming Hsieh, Michelle Castor, Ming-Tang Chen, Alan C. Cheng, Scott A. Hollingsworth, Veronica M. Juan, Madhura Shidhore, Song Yang, Renee C.T. Moore
  • PROSTAGLANDIN E2 BINDING PROTEINS AND USES THEREOF
    Publication number: 20140186377
    Abstract: The present invention encompasses prostaglandin E2 (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.
    Type: Application
    Filed: November 26, 2013
    Publication date: July 3, 2014
    Applicant: AbbVie, Inc.
    Inventors: Jijie Gu, Charles W. Hutchins, Rong-Rong Zhu, Jianwei Shen, Maria C. Harris, Eileen Belanger, Tariq Ghayur, Paul R. Hinton, Veronica M. Juan, John Mankovich, Junjian Liu
  • Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof
    Publication number: 20090232801
    Abstract: The present invention relates to binding proteins and, in particular, humanized antibodies that may be used, for example, in the diagnosis, treatment and prevention of Alzheimer's Disease and related conditions.
    Type: Application
    Filed: May 29, 2008
    Publication date: September 17, 2009
    Applicant: ABBOT LABORATORIES
    Inventors: Heinz Hillen, Stefan Barghorn, Ulrich Ebert, Andreas R. Striebinger, Patrick Keller, Boris Labkovsky, Paul R. Hinton, Veronica M. Juan
  • HUMANIZED ANTIBODIES TO AB (20-42) GLOBULOMER AND USES THEREOF
    Publication number: 20090175847
    Abstract: The present invention relates to binding proteins and, in particular, humanized antibodies that may be used, for example, in the diagnosis, treatment and prevention of Alzheimer's Disease and related conditions.
    Type: Application
    Filed: May 29, 2008
    Publication date: July 9, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Stefan Barghorn, Ulrich Ebert, Heinz Hillen, Patrick Keller, Andreas R. Striebinger, Boris Labkovsky, Paul R. Hinton, Veronica M. Juan