Abstract: A support system with repositionable bolsters with a panel of material, which can comprise elastomeric mesh, and bolsters repositionably securable to the panel of material. The panel of material can be retained relative to a bed or other structure or by a frame, which can be foldable. The bolsters, which can be formed with a breathable mesh shell, can be secured to the panel of material by a plurality of extendable and retractable fingers for being received through apertures in the panel of elastomeric material, by at least one expansible structure for being received through the apertures in the panel of elastomeric material and expanded, or by pivotable arms adjustable between generally parallel and non-parallel dispositions. The support system can be used independently or incorporated within a crib, bassinet, car seat, high chair, swing, bouncing seat or support, or any other support structure.