Patents by Inventor Veronika STEPANKOVA

Veronika STEPANKOVA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermostable FGF2 polypeptide, use thereof
    Patent number: 11746135
    Abstract: The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: September 5, 2023
    Assignees: Masarykova Univerzita, Enantis s.r.o.
    Inventors: Petr Dvorak, Pavel Krejci, Lukas Balek, Livia Eiselleova, Zaneta Konecna, Pavel Dvorak, David Bednar, Jan Brezovsky, Eva Sebestova, Radka Chaloupkova, Veronika Stepankova, Pavel Vanacek, Zbynek Prokop, Jiri Damborsky, Michaela Bosakova
  • Composition comprising an iodide and a derivative of hyaluronic acid with an oxidative effect, method of preparation thereof and use thereof
    Patent number: 11425907
    Abstract: An antimicrobial composition is provided. The composition comprises a chloramid of hyaluronic acid or of modified hyaluronic acid. The chloramid has an amidic group (—NH—CO—). The hydrogens of the amidic group are substituted by chlorine atoms according to the structural formula —NCl—CO—. The composition further comprises an iodide. The substitution degree of the hyaluronic acid or of the modified hyaluronic acid by chlorine is in an amount of from 50% to 100%.
    Type: Grant
    Filed: August 17, 2019
    Date of Patent: August 30, 2022
    Assignee: CONTIPRO A.S.
    Inventors: Radovan Buffa, Vit Svozil, Katerina Knotkova, Veronika Stepankova, Jaromir Kulhanek, Josef Chmelar, Lucie Marholdova, Ivana Basarabova, Michaela Moravkova, Helena Krejci, Kristyna Lipenska, Jaroslav Novotny, Stanislav Pepeliaev, Lubos Sobotka, Vladimir Velebny
  • COMPOSITION COMPRISING AN IODIDE AND A DERIVATIVE OF HYALURONIC ACID WITH AN OXIDATIVE EFFECT, METHOD OF PREPARATION THEREOF AND USE THEREOF
    Publication number: 20210345610
    Abstract: An antimicrobial composition is provided. The composition comprises a chloramid of hyaluronic acid or of modified hyaluronic acid. The chloramid has an amidic group (—NH—CO—). The hydrogens of the amidic group are substituted by chlorine atoms according to the structural formula —NCl—CO—. The composition further comprises an iodide. The substitution degree of the hyaluronic acid or of the modified hyaluronic acid by chlorine is in an amount of from 50% to 100%.
    Type: Application
    Filed: August 17, 2019
    Publication date: November 11, 2021
    Inventors: Radovan BUFFA, Vit SVOZIL, Katerina KNOTKOVA, Veronika STEPANKOVA, Jaromir KULHANEK, Josef CHMELAR, Lucie MARHOLDOVA, Ivana BASARABOVA, Michaela MORAVKOVA, Helena KREJCI, Kristyna LIPENSKA, Jaroslav NOVOTNY, Stanislav PEPELIAEV, Lubos SOBOTKA, Vladimir VELEBNY
  • Thermostable FGF2 Polypeptide, Use Thereof
    Publication number: 20200270320
    Abstract: The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.
    Type: Application
    Filed: October 3, 2016
    Publication date: August 27, 2020
    Inventors: Petr Dvorak, Pavel Krejci, Lukas Balek, Livia Eiselleova, Zaneta Konecna, Pavel Dvorak, David Bednar, Jan Brezovsky, Eva Sebestova, Radka Chaloupkova, Veronika Stepankova, Pavel Vanacek, Zbynek Prokop, Jiri Damborsky, Michaela Bosakova
  • ANTIMICROBIAL COMPOSITION COMPRISING A POLYSACCHARIDE, A STABILIZING AGENT AND TRIIODIDE, METHOD OF PREPARATION THEREOF AND USE THEREOF
    Publication number: 20200179445
    Abstract: A composition having antimicrobial activity is provided. The composition comprises a polysaccharide, a stabilizer, and a triiodide, where the triiodide decomposition to iodide and volatile iodine can be significantly suppressed by the presence of the stabilizer. Methods of preparing and using the composition and devices prepared therewith are also disclosed. As compared to liquid forms comprising triiodide, stabilized solid forms can be used for a much wider range of applications due to their shape stability and a significantly smaller volume and weight of total material.
    Type: Application
    Filed: June 1, 2018
    Publication date: June 11, 2020
    Inventors: Radovan BUFFA, Veronika STEPANKOVA, Ivana BASARABOVA, Josef CHMELAR, Katerina MAIRYCHOVA, Vojtech ZAPOTOCKY, Tomas PITUCHA, Katerina KNOTKOVA, Lubos SOBOTKA, Kristyna LIPENSKA, Vladimir VELEBNY
  • Method of thermostabilization of a protein and/or stabilization towards organic solvents
    Patent number: 8580932
    Abstract: Thermostabilization of a protein where the protein contains access routes and wherein at least one amino acid in the bottleneck of the access route is mutated, includes identifying the amino acids of the bottleneck and the amino acids control exchange of the solvent between a buried protein core and surrounding environment and/or in the packing of the amino acids inside the access route. Modification of the amino acids are determined so that the packing of the amino acids inside the tunnel is improved and the access route prevents access of undesired solvent molecules to the protein core, while allowing passage of the compounds necessary at the protein core to enable the protein to perform its biological function.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: November 12, 2013
    Assignee: Masarykova Univerzita
    Inventors: Jiri Damborsky, Zbynek Prokop, Tana Koudelakova, Veronika Stepankova, Radka Chaloupkova, Eva Chovancova, Artur Wiktor Gora, Jan Brezovsky
  • Method of thermostabilization of a protein and/or stabilization towards organic solvents
    Publication number: 20130102763
    Abstract: Thermostabilization of a protein where the protein contains access routes and wherein at least one amino acid in the bottleneck of the access route is mutated, includes identifying the amino acids of the bottleneck and the amino acids control exchange of the solvent between a buried protein core and surrounding environment and/or in the packing of the amino acids inside the access route. Modification of the amino acids are determined so that the packing of the amino acids inside the tunnel is improved and the access route prevents access of undesired solvent molecules to the protein core, while allowing passage of the compounds necessary at the protein core to enable the protein to perform its biological function.
    Type: Application
    Filed: September 5, 2012
    Publication date: April 25, 2013
    Inventors: Jiri DAMBORSKY, Zbynek PROKOP, Tana KOUDELAKOVA, Veronika STEPANKOVA, Radka CHALOUPKOVA, Eva CHOVANCOVA, Artur Wiktor GORA, Jan BREZOVSKY