Patents by Inventor Vervecken Wouter

Vervecken Wouter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein glycosylation modification in methylotrophic yeast
    Patent number: 8883445
    Abstract: The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains of Pichia are also provided. Vectors, which comprise coding sequences for ?-1,2-mannosidase I, glucosidase II, GlcNAc-tranferase I and mannosidase II or comprising OCH1 disrupting sequence, for transforming methylotrophic yeasts are contemplated by the present invention. Kit for providing the comtemplated vectors are also included in this invention.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: November 11, 2014
    Assignees: Research Corporation Technologies, Inc., Universiteit Gent, Vib, VZW
    Inventors: Roland Contreras, Nico L. M. Callewaert, Steven C. J. Geysens, Vladimir Kaigorodov, Vervecken Wouter
  • Protein glycosylation modification in methylotrophic yeast
    Publication number: 20080009037
    Abstract: The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains of Pichia are also provided. Vectors, which comprise coding sequences for ?-1,2-mannosidase I, glucosidase II, GlcNAc-tranferase I and mannosidase II or comprising OCH1 disrupting sequence, for transforming methylotrophic yeasts are contemplated by the present invention. Kit for providing the comtemplated vectors are also included in this invention.
    Type: Application
    Filed: July 13, 2007
    Publication date: January 10, 2008
    Applicant: Flanders Interuniversity Institute For Biotechnology
    Inventors: Roland Contreras, Nico Callewaert, Steven Geysens, Vladimir Kaigorodov, Vervecken Wouter
  • Protein glycosylation modification in methylotrophic yeast
    Patent number: 7252933
    Abstract: The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains of Pichia are also provided. Vectors, which comprise coding sequences for ?-1,2-mannosidase I, glucosidase II, GlcNAc-tranferase I and mannosidase II or comprising OCH1 disrupting sequence, for transforming methylotrophic yeasts are contemplated by the present invention. Kit for providing the comtemplated vectors are also included in this invention.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: August 7, 2007
    Assignee: Flanders Interuniversity Institute for Biotechnology
    Inventors: Roland Contreras, Nico L. M. Callewaert, Steven C. J. Geysens, Vladimir Kaigorodov, Vervecken Wouter
  • PROTEIN GLYCOSYLATION MODIFICATION IN METHYLOTROPHIC YEAST
    Publication number: 20040018588
    Abstract: The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains of Pichia are also provided. Vectors, which comprise coding sequences for &agr;-1,2-mannosidase I, glucosidase II, GlcNAc-tranferase I and mannosidase II or comprising OCH1 disrupting sequence, for transforming methylotrophic yeasts are contemplated by the present invention. Kit for providing the comtemplated vectors are also included in this invention.
    Type: Application
    Filed: June 26, 2002
    Publication date: January 29, 2004
    Inventors: Roland Contreras, Nico L.M. Callewaert, Steven C. J. Geysens, Vladimir Kaigorodov, Vervecken Wouter