Abstract: The present invention relates to a hydrogel material hydrogel material, comprising a first hydrogel comprising 0.15-21 wt-% of a functionalised triblock molecule having a formula (1) wherein n is 4-680 and m is 1-10, based on a total weight of the first hydrogel. The first hydrogel further comprises 0.85-3.3 wt-% of silica, based on the total weight of the first hydrogel, and 75-99 wt-% of an aqueous liquid, based on the total weight of the first hydrogel. The —Si—OH groups of the silica form a —Si—O—Si— bond with the —Si—(O)3— group of the functionalised triblock molecule of formula (1).

Abstract: An isolated protein which is structurally and functionally similar to avidin but with improved properties, such as better affinity towards biotin conjugate, useful immunological properties or faster biotin dissociation rate, compared to avidin and streptavidin.

Abstract: The present invention relates to new mutants of biotin binding proteins with improved properties, e.g., thermally stabilized compared to wild type proteins. Proteins, which bind biotin include chicken avidin and bacterial streptavidin, other poultry avidins, such as avidin proteins isolated from the duck, goose, ostrich and turkey, and chicken avidin-related proteins (AVRs).

Abstract: The present invention relates to new chimeric mutants of avidin protein with improved properties, e.g. thermostability, better stability against proteolysis, better charge properties (for example lower pl) compared to native avidin and avidin-related proteins, AVRs. The chimeric avidin mutants comprise mutants where a region or regions in avidin are substituted by a corresponding region or regions from an AVR protein.