Patents by Inventor Vesna PULKO

Vesna PULKO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Car-t cell assay for specificity test of novel antigen binding moieties
    Patent number: 11788205
    Abstract: The present invention generally relates to specificity assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter T (CAR-T cell) assays to test antigen binding moieties in different formats. Furthermore, the present invention relates to the use of CAR-T cells, transfected/transduced with an engineered chimeric antigen receptor (CAR) comprising a target antigen binding moiety capable of specific binding to a target antigen, e.g., tumor associated antigens.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: October 17, 2023
    Inventors: Christian Klein, Ekkehard Moessner, Lydia Jasmin Hanisch, Wei Xu, Camille Loise Sophie Delon, Diana Darowski, Christian Jost, Vesna Pulko
  • DIAGNOSTIC ASSAYS TO DETECT TUMOR ANTIGENS IN CANCER PATIENTS
    Publication number: 20210025894
    Abstract: The present invention generally relates to diagnostic assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter cell assays to analyze samples, in particular patient samples, to diagnose cancer by quantifying the expression of tumor antigens and/or predicting clinical response to cancer immunotherapies. A further aspect of the present invention is to improve safety of e.g., cancer immunotherapies.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 28, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Diana DAROWSKI, Camille Loise Sophie DELON, Lydia Jasmin HANISCH, Christian KLEIN, Christian JOST, Ekkehard MOESSNER, Vesna PULKO, Wei XU
  • DIAGNOSTIC ASSAYS TO DETECT TUMOR ANTIGENS IN CANCER PATIENTS
    Publication number: 20210018509
    Abstract: The present invention generally relates to diagnostic assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter cell assays to analyze samples, in particular patient samples, to diagnose cancer by quantifying the expression of tumor antigens and/or predicting clinical response to cancer immunotherapies. A further aspect of the present invention is to improve safety of e.g., cancer immunotherapies.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 21, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Diana DAROWSKI, Camille Loise Sophie DELON, Lydia Jasmin HANISCH, Christian JOST, Christian KLEIN, Ekkehard MOESSNER, Vesna PULKO, Wei XU
  • CAR-T CELL ASSAY FOR SPECIFICITY TEST OF NOVEL ANTIGEN BINDING MOIETIES
    Publication number: 20200318105
    Abstract: The present invention generally relates to specificity assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter T (CAR-T cell) assays to test antigen binding moieties in different formats. Furthermore, the present invention relates to the use of CAR-T cells, transfected/transduced with an engineered chimeric antigen receptor (CAR) comprising a target antigen binding moiety capable of specific binding to a target antigen, e.g., tumor associated antigens.
    Type: Application
    Filed: June 19, 2020
    Publication date: October 8, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian KLEIN, Ekkehard MOESSNER, Lydia Jasmin HANISCH, Wei XU, Camille Loise Sophie DELON, Diana DAROWSKI, Christian JOST, Vesna PULKO
  • UNIVERSAL REPORTER CELL ASSAY FOR SPECIFICITY TEST OF NOVEL ANTIGEN BINDING MOIETIES
    Publication number: 20200316128
    Abstract: The present invention generally relates to specificity assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter T (CAR-T) cell assays to test novel antigen binding moieties in different formats. Furthermore, the present invention relates to the use of CAR-T cells, transfected/transduced with an engineered chimeric antigen receptor (CAR) comprising a target antigen binding moiety capable of specific binding to a recognition domain of an antigen binding molecule. The invention also relates to methods and kits for specificity testing of a candidate antigen binding moiety and/or nucleic acid molecules and vectors expressing engineered CARs.
    Type: Application
    Filed: June 19, 2020
    Publication date: October 8, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian KLEIN, Ekkehard MOESSNER, Lydia Jasmin HANISCH, Wei XU, Camille Loise Sophie DELON, Diana DAROWSKI, Christian JOST, Vesna PULKO