Abstract: Method and apparatus for measurement and analysis of soft particles in liquids in the size range 1-500 ?m represented by vesicles and living cells, liposomes and blood cells in particular, but also to diluted dispersions of oil droplets and other confined microparticles in liquids. The method is based on amperometric detection and analysis of single events of particle adhesion in raw samples, or after the concentration adjustment, by means of permanent record of time series of stochastic electrical signals in the real time. The detected new class of electrical signals is generated by adhesion causing the deformation, rupture and spreading of soft particles at mercury electrode in air saturated liquids. Information stored in one current pulse signal is: particle size, adhesion properties and electrode surface area occupied by the spread particle, which is characteristic for each class of particles.