Abstract: Methods and systems for cancelling self-interference in a full-duplex radio transceiver. The methods comprising transmitting a transmit signal from a transmit path of the transceiver and receiving a receive signal at a receive path of the transceiver. The receive signal comprises a self-interference signal component caused by to self-interference between the transmit path and the receive path. The methods further comprising generating a filtered signal by filtering an initial signal using an adaptive filter, the adaptive filter being configured based on a target signal derived from the receive signal, wherein the initial signal is derived from the transmit signal; and subtracting a cancellation signal from the receive signal; the cancellation signal being derived from the filtered signal.