Patents by Inventor Vibha Pathak

Vibha Pathak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFICATION OF NOVEL BENZOTHIAZONES AS TAU-SH3 INTERACTION INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE
    Publication number: 20250367209
    Abstract: The present disclosure is concerned with benzothiazone compounds that are capable of inhibiting Tau-SH3 signaling. The present disclosure is also concerned with methods of using these compounds for the treatment of neurological disorders such as, for example, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, epilepsy, autism spectrum disorders, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: June 21, 2023
    Publication date: December 4, 2025
    Inventors: Corinne E. AUGELLI-SZAFRAN, Vibha PATHAK, Mark J. SUTO, Erik D. ROBERSON
  • RNA-binding protein multimerization inhibitors and methods of use thereof
    Patent number: 12435091
    Abstract: This disclosure provides compounds that inhibit RNA-binding proteins, such as Human antigen R protein (HuR). The compounds described herein have a high affinity for HuR multimers and inhibit the pathological processes that promote cancer and inflammation. The compounds are highly water-soluble and have good biodistribution for both systemic and central nervous system disease processes. The compounds provide a unique therapeutic option for disease processes related to neoplastic progression or acute or chronic inflammation.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: October 7, 2025
    Assignees: The UAB Research Foundation, Southern Research Institute, The United States Government as Represented by the Department of Veteran Affairs
    Inventors: Louis B. Nabors, Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Vibha Pathak, Peter King
  • RNA-BINDING PROTEIN MULTIMERIZATION INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20230159542
    Abstract: This disclosure provides compounds that inhibit RNA-binding proteins, such as Human antigen R protein (HuR). The compounds described herein have a high affinity for HuR multimers and inhibit the pathological processes that promote cancer and inflammation. The compounds are highly water-soluble and have good biodistribution for both systemic and central nervous system disease processes. The compounds provide a unique therapeutic option for disease processes related to neoplastic progression or acute or chronic inflammation.
    Type: Application
    Filed: April 21, 2021
    Publication date: May 25, 2023
    Applicants: THE UAB RESEARCH FOUNDATION, SOUTHERN RESEARCH INSTITUTE, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Louis B. Nabors, Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Vibha Pathak, Peter King
  • SUBSTITUTED HETEROCYCLIC-PYRIDINONES AS HIV-1 NEF-HCK INHIBITORS
    Publication number: 20200385406
    Abstract: Disclosed are heterocyclic-pyridinone analogs that are capable of inhibiting Nef-Hck and methods of treating viral infections such as, for example, HIV-1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: December 20, 2018
    Publication date: December 10, 2020
    Inventors: Corinne E. Augelli-Szafran, Omar Moulkha-Chafiq, Thomas E. Smithgall, Lori A. Emert-Sedlak, Habin Shi, Samuel Tanner, Vibha Pathak
  • Benzimidazole Compounds, Use As Inhibitors of WNT Signaling Pathway in Cancers, and Methods for Preparation Thereof
    Publication number: 20170210741
    Abstract: The present disclosure is concerned with benzimidazole compounds that are capable of inhibiting Wnt signaling and methods of treating disease states such as, for example, cancer, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: January 27, 2017
    Publication date: July 27, 2017
    Inventors: Corinne E. AUGELLI-SZAFRAN, Mark J. Suto, Vibha Pathak, Han-Xun Wei, Donald Buchsbaum
  • Adjuvant
    Patent number: 8883170
    Abstract: Methods and immunogenic compositions for generating an immune response against Marburg virus are provided. The immunogenic composition includes antigens obtained from a Marburg viral strain in combination with an oleanolic acid triterpene adjuvant.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: November 11, 2014
    Assignees: Western Illinois University Research Foundation, Southern Research Institute
    Inventors: Ashish Kumar Pathak, Vibha Pathak, Richard D. May
  • Vaccine Compositions For Marburg Virus
    Publication number: 20120136142
    Abstract: Methods and immunogenic compositions for generating an immune response against Marburg virus are provided. The immunogenic composition includes antigens obtained from a Marburg viral strain in combination with an oleanolic acid triterpene adjuvant.
    Type: Application
    Filed: September 3, 2008
    Publication date: May 31, 2012
    Applicants: SOUTHERN RESEARCH INSTITUTE, WESTERN ILLINOIS UNIVERSITY RESEARCH FOUNDATION
    Inventors: Ashish Kumar Pathak, Vibha Pathak, Richard D. May