Patents by Inventor VIBHUTI AGRAHARI

VIBHUTI AGRAHARI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING THERAPEUTIC-INDUCED TOXICITIES
    Publication number: 20240423976
    Abstract: A method and composition for mitigating or reducing drug-induced ototoxicity or drug-induced hearing loss in a subject in need of such treatment, comprising: providing a drug delivery system which releases a therapeutic drug upon exposure to reactive oxygen species, wherein the drug delivery system comprises a thermoresponsive hydrogel containing therapeutic drug-loaded crosslinked hybrid nanoparticles and provides sustained therapeutic drug release. The crosslinked hybrid nanoparticles within which the therapeutic drug is loaded may comprise 10,12-Pentacosadiynoic acid (PCDA) and polypropylene sulfide-polyethylene glycol monomethyl ether (PPS-mPEG). The drug-induced ototoxicity or hearing loss may be caused by cisplatin or other platinum-based drugs.
    Type: Application
    Filed: June 21, 2024
    Publication date: December 26, 2024
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
    Inventors: Vibhuti AGRAHARI, Neeraj S. THAKUR
  • METHOD FOR PREPARING LOADED NANOPARTICLES
    Publication number: 20170260326
    Abstract: Novel pentablock polymers having a PCL-PLA-PEG-PLA-PCL or PCL-PGA-PEG-PGA-PCL configuration, wherein PEG is polyethylene glycol, PCL is poly(?-caprolactone), PGA is poly(glycolic acid), and PLA is poly(lactic acid), and methods of making nanoparticles from the pentablock polymers, are disclosed. The invention is also directed to a method for preparing nanoparticle compositions comprised of polymers with high levels of bioactive or diagnostic agents.
    Type: Application
    Filed: February 15, 2017
    Publication date: September 14, 2017
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: ASHIM K. MITRA, SULABH P. PATEL, RAVI D. VAISHYA, VIBHUTI AGRAHARI
  • Drug loading pentablock polymers
    Patent number: 9611353
    Abstract: Novel pentablock polymers having a PCL-PLA-PEG-PLA-PCL or PCL-PGA-PEG-PGA-PCL configuration, wherein PEG is polyethylene glycol, PCL is poly(8-caprolactone), PGA is poly(glycolic acid), and PLA is poly(lactic acid), and methods of making nanoparticles from the pentablock polymers, are disclosed. The invention is also directed to a method for preparing nanoparticle compositions comprised of polymers with high levels of bioactive or diagnostic agents.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: April 4, 2017
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Ashim K. Mitra, Sulabh P. Patel, Ravi D. Vaishya, Vibhuti Agrahari
  • DRUG LOADING PENTABLOCK POLYMERS
    Publication number: 20160090444
    Abstract: Novel pentablock polymers having a PCL-PLA-PEG-PLA-PCL or PCL-PGA-PEG-PGA-PCL configuration, wherein PEG is polyethylene glycol, PCL is poly(8-caprolactone), PGA is poly(glycolic acid), and PLA is poly(lactic acid), and methods of making nanoparticles from the pentablock polymers, are disclosed. The invention is also directed to a method for preparing nanoparticle compositions comprised of polymers with high levels of bioactive or diagnostic agents.
    Type: Application
    Filed: May 16, 2014
    Publication date: March 31, 2016
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: ASHIM K. MITRA, SULABH P. PATEL, RAVI D. VAISHYA, VIBHUTI AGRAHARI