Patents by Inventor Vickie L. Brown-Driver

Vickie L. Brown-Driver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of telomere length by oligonucleotides having a G-core sequence
    Publication number: 20030096776
    Abstract: Modified oligonucleotides having a GGG motif sequence and a sufficient number of flanking nucleotides to modulate the telomere length of a chromosome are provided. Methods of modulating telomere length of a mammalian chromosome in vitro and in vivo are also provided, as are methods for inhibiting the division of a malignant mammalian cell and for modulating the effects of cellular aging.
    Type: Application
    Filed: January 2, 2002
    Publication date: May 22, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Ronnie C. Hanecak, Kevin P. Anderson, C. Frank Bennett, Ming-Yi Chiang, Vickie L. Brown-Driver, David J. Ecker, Timothy A. Vickers, Jacqueline R. Wyatt
  • Antisense inhibition of e2f transcription factor 1 expression
    Patent number: 6187587
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of E2F transcription factor 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding E2F transcription factor 1. Methods of using these compounds for modulation of E2F transcription factor 1 expression and for treatment of diseases associated with expression of E2F transcription factor 1 are provided.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: February 13, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Ian Popoff, Vickie L. Brown-Driver, Lex M. Cowsert
  • Oligonucleotides having a conserved G4 core sequence
    Patent number: 5952490
    Abstract: Modified oligonucleotides having a conserved G.sub.4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus such as HSV-1 or phospholipase A.sub.2 or to modulate the telomere length of a chromosome are provided. G.sub.4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnosis and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A.sub.2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to plat a role in the aging process of a cell and in control of malignant cell growth.
    Type: Grant
    Filed: June 12, 1995
    Date of Patent: September 14, 1999
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Ronnie C. Hanecak, Kevin P. Anderson, C. Frank Bennett, Ming-Yi Chiang, Vickie L. Brown-Driver, David J. Ecker, Timothy A. Vickers, Jacqueline R. Wyatt, Jean Louis Imbach
  • Oligonucleotide therapies for modulating the effects of herpes viruses
    Patent number: 5514577
    Abstract: Compositions and methods are provided for the treatment and diagnosis of herpesvirus infections. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from a herpesvirus gene corresponding to one of the open reading frames UL5, UL8, UL9, UL20, UL27, UL29, UL30, UL42, UL52 and IE175 of herpes simplex virus type 1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a translation initiation site, a coding region or a 5'-untranslated region. Methods of treating animals suspected of being infected with herpesvirus comprising contacting the animal with an oligonucleotide of the invention are disclosed.
    Type: Grant
    Filed: March 12, 1993
    Date of Patent: May 7, 1996
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Kenneth G. Draper, Stanley T. Crooke, Christopher K. Mirabelli, David J. Ecker, Ronnie C. Hanecak, Kevin P. Anderson, Vickie L. Brown-Driver, Jacqueline R. Wyatt