Patents by Inventor Vicky Vydra

Vicky Vydra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for leukotriene biosynthesis inhibition
    Patent number: 7915298
    Abstract: This invention provides novel salt and crystalline forms thereof of (?)4-(4-fluorophenyl)-7-[({5-[1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl}amino)-methyl]-2H-chromen-2-one. The compounds are 5-LO inhibitors and are useful for treatment of conditions such as asthma, allergic rhinitis, COPD, and atherosclerosis.
    Type: Grant
    Filed: September 24, 2008
    Date of Patent: March 29, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Francis Gosselin, Vicky Vydra
  • SYNTHESIS AND CRYSTALLINE FORMS OF CB-1 ANTAGONIST/INVERSE AGONIST
    Publication number: 20100292282
    Abstract: The present invention relates to a process for producing crystalline 3-[(1S)-1-(1-{(S)-(4-chlorophenyl)[3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]methyl}azetidin-3-yl)-2-fluoro-2-methyl-propyl]-5-fluorobenzonitrile, and novel salts, solvates, hydrates and polymorphs thereof.
    Type: Application
    Filed: October 20, 2008
    Publication date: November 18, 2010
    Inventors: Kevin R. Campos, Cheng-Yi Chen, Jennifer R. Foley, Michael Hillier, Wendy S. Jen, Amude M. Kassim, Artis Klapars, Andrey V. Peresypkin, Thorsten Rosner, Cecile G. Savarin, Matthew Tudge, Narayan Variankaval, Vicky Vydra, Dalian Zhao
  • Compounds and methods for leukotriene biosynthesis inhibition
    Publication number: 20090088477
    Abstract: This invention provides novel salt and crystalline forms thereof of (?)4-(4-fluorophenyl)-7-[({5-[1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl}amino)-methyl]-2H-chromen-2-one. The compounds are 5-LO inhibitors and are useful for treatment of conditions such as asthma, allergic rhinitis, COPD, and atherosclerosis.
    Type: Application
    Filed: September 24, 2008
    Publication date: April 2, 2009
    Inventors: Francis Gosselin, Vicky Vydra
  • Phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor
    Publication number: 20050032804
    Abstract: The dihydrogenphosphate salt of 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine is a potent inhibitor of dipeptidyl peptidase-IV and is useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as type 2 diabetes. The invention also relates to a crystalline monohydrate of the dihydrogenphosphate salt as well as a process for its preparation, pharmaceutical compositions containing this novel form and methods of use for the treatment of diabetes, obesity, and high blood pressure.
    Type: Application
    Filed: June 23, 2004
    Publication date: February 10, 2005
    Inventors: Stephen Cypes, Alex Chen, Russell Ferlita, Karl Hansen, Ivan Lee, Vicky Vydra, Robert Wenslow