Patents by Inventor Victor A. Raso

Victor A. Raso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for delivering functional domains of diphtheria toxin to a cellular target
    Patent number: 5830478
    Abstract: The method of the present invention employs a hybrid reagent comprising a first portion (i.e., a cell-targeting portion) which binds to cell surfaces coupled to a second portion (i.e., a toxin-binding portion) which binds to, or has bound to it, an endosomally active domain of DT and releases the endosomally active domain of DT in response to the low pH in endosomal vesicles of cells. Thus, the second portion of the hybrid reagent binds an endosomally active domain directly (e.g., an antibody which binds to all or a portion of the T domain of DT) or indirectly (e.g., an antibody which binds to the R domain of a moiety in which the R domain of DT is coupled to the T domain of DT). A second endosomally active domain of DT, which is different from the first endosomally active domain of DT, is delivered to the same endosomal vesicles separately. The independent endosomally active domains of DT are not toxic to cells until they meet within the endosomes.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 3, 1998
    Assignee: Boston Biomedical Research Institute
    Inventors: Victor A. Raso, Katherine Sheldon
  • Method for delivering a bioactive molecule to a cellular target
    Patent number: 5603931
    Abstract: Hybrid reagents comprising a first portion having an affinity for a cellular target and a second portion having an affinity for a bioactive molecule are described, said hybrid reagents being capable of selectively releasing the bioactive molecule in response to a change in pH. The hybrid reagents of the present invention can be used diagnostically or therapeutically.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: February 18, 1997
    Assignee: Boston Biomedical Research Institute
    Inventor: Victor A. Raso
  • Method for constructing a hybrid reagent for delivering a bioactive molecule to a cellular target
    Patent number: 5599908
    Abstract: Hybrid reagents comprising a first portion having an affinity for a cellular target and a second portion having an affinity for a bioactive molecule are described, said hybrid reagents being capable of selectively releasing the bioactive molecule in response to a change in pH. The hybrid reagents of the present invention can be used diagnostically or therapeutically.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: February 4, 1997
    Assignee: Boston Biomedical Research Institute
    Inventor: Victor A. Raso
  • Hybrid reagents capable of selectively releasing molecules into cells
    Patent number: 5501854
    Abstract: Hybrid reagents comprising a first portion having an affinity for a cellular target and a second portion having an affinity for a bioactive molecule are described, said hybrid reagents being capable of selectively releasing the bioactive molecule in response to a change in pH. The hybrid reagents of the present invention can be used diagnostically or therapeutically.
    Type: Grant
    Filed: December 28, 1992
    Date of Patent: March 26, 1996
    Assignee: Boston Biomedical Research Institute
    Inventor: Victor A. Raso